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Article: Profile of pre-S deletions in the natural history of chronic hepatitis B infection.

TitleProfile of pre-S deletions in the natural history of chronic hepatitis B infection.
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 2010, v. 82 n. 11, p. 1843-1849 How to Cite?
AbstractIt have been suggested that hepatitis B virus (HBV) pre-S deletions may play a role in hepatocarcinogenesis. The aim of the study was to determine the prevalence of pre-S deletions in chronic hepatitis B patients in Hong Kong, the factors associated with the deletions and its relationship with hepatitis B e antigen (HBeAg) seroconversion. HBV pre-S deletions were determined by nucleotide sequence analysis in 178 patients with chronic HBV (cross-sectional study). Eighty-four patients had paired samples before and after HBeAg seroconversion (longitudinal study). The prevalence of pre-S deletions was 12.9% (23/178). A majority of the pre-S deletions (73.9%) occurred in the 5' terminus of pre-S2 region whereas deletions in the pre-S1 region appeared less frequently (47.8%). There was no relationship between age and pre-S deletions. Male gender [odds ratio (OR)=10.88; 95% confidence interval (CI)=1.37-86.52; P=0.024] and HBV genotype C (OR=13.85; 95% CI=3.05-62.92; P=0.001) were independent factors associated with pre-S deletions. Only 17 out of the 84 patients with paired samples before and after HBeAg seroconversion had pre-S deletions. The patterns of pre-S deletions before and after HBeAg seroconversion were variable. Compared with genotype B, HBV genotype C was associated with earlier emergence of pre-S deletions. In conclusion, 12.9% of chronic HBV carriers had pre-S deletions (predominantly pre-S2 deletions) in a geographical area highly endemic for chronic hepatitis B. Male gender and HBV genotype C were associated independently with the development of pre-S deletion mutations. There was no clear relationship between HBeAg seroconversion and pre-S deletions. © 2010 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135240
ISSN
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYeung, Pen_HK
dc.contributor.authorWong, DKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2011-07-27T01:30:28Z-
dc.date.available2011-07-27T01:30:28Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Medical Virology, 2010, v. 82 n. 11, p. 1843-1849en_HK
dc.identifier.issn1096-9071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135240-
dc.description.abstractIt have been suggested that hepatitis B virus (HBV) pre-S deletions may play a role in hepatocarcinogenesis. The aim of the study was to determine the prevalence of pre-S deletions in chronic hepatitis B patients in Hong Kong, the factors associated with the deletions and its relationship with hepatitis B e antigen (HBeAg) seroconversion. HBV pre-S deletions were determined by nucleotide sequence analysis in 178 patients with chronic HBV (cross-sectional study). Eighty-four patients had paired samples before and after HBeAg seroconversion (longitudinal study). The prevalence of pre-S deletions was 12.9% (23/178). A majority of the pre-S deletions (73.9%) occurred in the 5' terminus of pre-S2 region whereas deletions in the pre-S1 region appeared less frequently (47.8%). There was no relationship between age and pre-S deletions. Male gender [odds ratio (OR)=10.88; 95% confidence interval (CI)=1.37-86.52; P=0.024] and HBV genotype C (OR=13.85; 95% CI=3.05-62.92; P=0.001) were independent factors associated with pre-S deletions. Only 17 out of the 84 patients with paired samples before and after HBeAg seroconversion had pre-S deletions. The patterns of pre-S deletions before and after HBeAg seroconversion were variable. Compared with genotype B, HBV genotype C was associated with earlier emergence of pre-S deletions. In conclusion, 12.9% of chronic HBV carriers had pre-S deletions (predominantly pre-S2 deletions) in a geographical area highly endemic for chronic hepatitis B. Male gender and HBV genotype C were associated independently with the development of pre-S deletion mutations. There was no clear relationship between HBeAg seroconversion and pre-S deletions. © 2010 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763-
dc.relation.ispartofJournal of medical virologyen_HK
dc.rightsJournal of Medical Virology. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshDisease Progression-
dc.subject.meshHepatitis B Surface Antigens - genetics-
dc.subject.meshHepatitis B virus - classification - genetics-
dc.subject.meshHepatitis B, Chronic - epidemiology - physiopathology - virology-
dc.subject.meshProtein Precursors - genetics-
dc.titleProfile of pre-S deletions in the natural history of chronic hepatitis B infection.en_HK
dc.typeArticleen_HK
dc.identifier.emailWong, DK: danywong@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFung, J: jfung@sicklehut.comen_HK
dc.identifier.emailSeto, WK: wkseto2@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.authorityWong, DK=rp00492en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmv.21901-
dc.identifier.pmid20872710en_HK
dc.identifier.scopuseid_2-s2.0-79952197374en_HK
dc.identifier.hkuros188143en_US
dc.identifier.hkuros189967-
dc.identifier.hkuros213671-
dc.identifier.volume82en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1843en_HK
dc.identifier.epage1849en_HK
dc.identifier.isiWOS:000282266900006-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridYeung, P=35081534000en_HK
dc.identifier.scopusauthoridWong, DK=7401535819en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK

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