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Article: C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort
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TitleC-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort
 
AuthorsCheung, BMY1
Ong, KL1
Tso, AWK1
Leung, RYH1
Xu, A1
Cherny, SS1
Sham, PC1
Lam, TH1
Lam, KSL1
 
KeywordsC-reactive protein
gene
single-nucleotide polymorphism
 
Issue Date2012
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
CitationJournal Of Human Hypertension, 2012, v. 26 n. 2, p. 108-116 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2010.125
 
AbstractInflammation contributes to the development of hypertension. Whether C-reactive protein (CRP) has a causal role in hypertension remains unknown. We studied the relationship between circulating CRP levels and hypertension. The role of single-nucleotide polymorphisms (SNPs) in the CRP gene as determinants of its plasma levels and the propensity to develop hypertension was investigated. Plasma CRP and genotypes of nine SNPs were determined in 1925 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004. Among 1378 subjects normotensive in CRISPS-2, 1115 subjects had been followed up in CRISPS-3 after a median interval of 5.3 years, 236 of whom had developed hypertension. Plasma CRP was independently associated with the development of hypertension in CRISPS-3 (odds ratio per quartile1.26, P=0.010). Six SNPs were associated with plasma CRP (all P<0.001). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension, or change in blood pressure. In conclusion, plasma CRP predicts the development of hypertension. Genetic variants in the CRP gene are significantly associated with plasma CRP but not with hypertension. The future risk of hypertension is therefore more related to plasma CRP than SNPs in the CRP gene in this population. © 2012 Macmillan Publishers Limited All rights reserved.
 
ISSN0950-9240
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
 
DOIhttp://dx.doi.org/10.1038/jhh.2010.125
 
ISI Accession Number IDWOS:000299309700005
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

Analysis using the Sequenom genotyping system was performed with the help of Miss Phoebe Ng of the Genome Research Centre, University of Hong Kong. This study was supported by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, BMY
 
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorXu, A
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2011-07-27T01:30:03Z
 
dc.date.available2011-07-27T01:30:03Z
 
dc.date.issued2012
 
dc.description.abstractInflammation contributes to the development of hypertension. Whether C-reactive protein (CRP) has a causal role in hypertension remains unknown. We studied the relationship between circulating CRP levels and hypertension. The role of single-nucleotide polymorphisms (SNPs) in the CRP gene as determinants of its plasma levels and the propensity to develop hypertension was investigated. Plasma CRP and genotypes of nine SNPs were determined in 1925 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004. Among 1378 subjects normotensive in CRISPS-2, 1115 subjects had been followed up in CRISPS-3 after a median interval of 5.3 years, 236 of whom had developed hypertension. Plasma CRP was independently associated with the development of hypertension in CRISPS-3 (odds ratio per quartile1.26, P=0.010). Six SNPs were associated with plasma CRP (all P<0.001). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension, or change in blood pressure. In conclusion, plasma CRP predicts the development of hypertension. Genetic variants in the CRP gene are significantly associated with plasma CRP but not with hypertension. The future risk of hypertension is therefore more related to plasma CRP than SNPs in the CRP gene in this population. © 2012 Macmillan Publishers Limited All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Human Hypertension, 2012, v. 26 n. 2, p. 108-116 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2010.125
 
dc.identifier.citeulike8764474
 
dc.identifier.doihttp://dx.doi.org/10.1038/jhh.2010.125
 
dc.identifier.epage116
 
dc.identifier.hkuros187102
 
dc.identifier.isiWOS:000299309700005
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

Analysis using the Sequenom genotyping system was performed with the help of Miss Phoebe Ng of the Genome Research Centre, University of Hong Kong. This study was supported by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

 
dc.identifier.issn0950-9240
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
 
dc.identifier.issue2
 
dc.identifier.pmid21270838
 
dc.identifier.scopuseid_2-s2.0-84855860049
 
dc.identifier.spage108
 
dc.identifier.urihttp://hdl.handle.net/10722/135214
 
dc.identifier.volume26
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Human Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.subjectC-reactive protein
 
dc.subjectgene
 
dc.subjectsingle-nucleotide polymorphism
 
dc.titleC-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort
 
dc.typeArticle
 
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<contributor.author>Xu, A</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
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Author Affiliations
  1. The University of Hong Kong