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Article: Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese

TitleGamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese
Authors
Keywordsγ-Glutamyl transaminase
GGT
Hypertension
Liver function test
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca
Citation
Clinica Chimica Acta, 2011, v. 412 n. 15-16, p. 1326-1331 How to Cite?
AbstractBackground: Plasma activities of alkaline phosphatase, alanine aminotransferase (ALT), aspartate aminotransferase, and γ-glutamyl transferase (GGT) are often increased in cardiometabolic diseases. We investigated if hypertension is associated with increased activities of these plasma markers. Methods: We included 235 hypertensive and 708 normotensive subjects (mean age 47.3 ± 9.6 and 58.0 ± 10.2. years respectively) from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004 who had drank < 1/week. In the follow-up study in 2005-2008 (CRISPS-3), 126 out of the 708 subjects had developed hypertension. Results: Raised plasma ALT (OR = 1.22 per SD of log-transformed level, P=0.045) and GGT (OR = 1.38 per SD of log-transformed level, P=0.001) levels were associated with hypertension at baseline in CRISPS-2 after adjusting for covariates. Among subjects not on anti-hypertensive medications, plasma ALP, ALT and GGT were related to blood pressure (P< 0.01). In subjects normotensive at CRISPS-2, plasma GGT, but not ALP, ALT and AST, was an independent predictor of new-onset hypertension at CRISPS-3 (OR = 1.38 per SD of log-transformed level, P=0.020 and OR = 2.68 for 3rd tertile vs. 1st tertile, P=0.004) after adjusting for covariates. Conclusions: Among the 4 plasma markers, increased GGT activity is the strongest predictor for existing and new-onset hypertension in Hong Kong Chinese. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/135210
ISSN
2015 Impact Factor: 2.799
2015 SCImago Journal Rankings: 1.040
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants Council7229/01M
7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

CRISPS-2 and CRISPS-3 studies were supported by grants from the Hong Kong Research Grants Council (#7229/01M and #7626/07M) and the Sun Chieh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2011-07-27T01:30:01Z-
dc.date.available2011-07-27T01:30:01Z-
dc.date.issued2011en_HK
dc.identifier.citationClinica Chimica Acta, 2011, v. 412 n. 15-16, p. 1326-1331en_HK
dc.identifier.issn0009-8981en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135210-
dc.description.abstractBackground: Plasma activities of alkaline phosphatase, alanine aminotransferase (ALT), aspartate aminotransferase, and γ-glutamyl transferase (GGT) are often increased in cardiometabolic diseases. We investigated if hypertension is associated with increased activities of these plasma markers. Methods: We included 235 hypertensive and 708 normotensive subjects (mean age 47.3 ± 9.6 and 58.0 ± 10.2. years respectively) from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004 who had drank < 1/week. In the follow-up study in 2005-2008 (CRISPS-3), 126 out of the 708 subjects had developed hypertension. Results: Raised plasma ALT (OR = 1.22 per SD of log-transformed level, P=0.045) and GGT (OR = 1.38 per SD of log-transformed level, P=0.001) levels were associated with hypertension at baseline in CRISPS-2 after adjusting for covariates. Among subjects not on anti-hypertensive medications, plasma ALP, ALT and GGT were related to blood pressure (P< 0.01). In subjects normotensive at CRISPS-2, plasma GGT, but not ALP, ALT and AST, was an independent predictor of new-onset hypertension at CRISPS-3 (OR = 1.38 per SD of log-transformed level, P=0.020 and OR = 2.68 for 3rd tertile vs. 1st tertile, P=0.004) after adjusting for covariates. Conclusions: Among the 4 plasma markers, increased GGT activity is the strongest predictor for existing and new-onset hypertension in Hong Kong Chinese. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccaen_HK
dc.relation.ispartofClinica Chimica Actaen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Clinica Chimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinica Chimica Acta, 2011, v. 412 n. 15-16, p. 1326-1331. DOI: 10.1016/j.cca.2011.03.030-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectγ-Glutamyl transaminaseen_HK
dc.subjectGGTen_HK
dc.subjectHypertensionen_HK
dc.subjectLiver function testen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshBiological Markers - blood - metabolismen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiology - ethnologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blood - enzymology - epidemiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshgamma-Glutamyltransferase - blood - metabolismen_HK
dc.titleGamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.cca.2011.03.030en_HK
dc.identifier.pmid21466796en_HK
dc.identifier.scopuseid_2-s2.0-79956298906en_HK
dc.identifier.hkuros187096en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956298906&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume412en_HK
dc.identifier.issue15-16en_HK
dc.identifier.spage1326en_HK
dc.identifier.epage1331en_HK
dc.identifier.isiWOS:000291917500005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.citeulike9151856-

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