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Article: Are patient characteristics associated with the accuracy of hysterosalpingography in diagnosing tubal pathology? An individual patient data meta-analysis

TitleAre patient characteristics associated with the accuracy of hysterosalpingography in diagnosing tubal pathology? An individual patient data meta-analysis
Authors
KeywordsDiagnostic accuracy
Hysterosalpingography
Individual patient data meta-analysis
Systematic review
Tubal pathology
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://humupd.oxfordjournals.org
Citation
Human Reproduction Update, 2011, v. 17 n. 3, p. 293-300 How to Cite?
AbstractBackground: Conventional meta-analysis has estimated the sensitivity and specificity of hysterosalpingography (HSG) to be 65% and 83%. The impact of patient characteristics on the accuracy of HSG is unknown. The aim of this study was to assess by individual patient data meta-analysis whether the accuracy of HSG is associated with different patient characteristics. Methods: We approached authors of primary studies reporting on the accuracy of HSG using findings at laparoscopy as the reference. We assessed whether patient characteristics such as female age, duration of subfertility and a clinical history without risk factors for tubal pathology were associated with the accuracy of HSG, using a random intercept logistic regression model. Results: We acquired data of seven primary studies containing data of 4521 women. Pooled sensitivity and specificity of HSG were 53% and 87% for any tubal pathology and 46% and 95% for bilateral tubal pathology. In women without risk factors, the sensitivity of HSG was 38% for any tubal pathology, compared with 61% in women with risk factors (P = 0.005). For bilateral tubal pathology, these rates were 13% versus 47% (P = 0.01). For bilateral tubal pathology, the sensitivity of HSG decreased with age [factor 0.93 per year (P = 0.05)]. The specificity of HSG was very stable across all subgroups. Conclusions: The accuracy of HSG in detecting tubal pathology was similar in all subgroups, except for women without risk factors in whom sensitivity was lower, possibly due to false-positive results at laparoscopy. HSG is a useful tubal patency screening test for all infertile couples. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/134489
ISSN
2015 Impact Factor: 11.194
2015 SCImago Journal Rankings: 4.678
ISI Accession Number ID
Funding AgencyGrant Number
ZonMW90700201
Funding Information:

This study was financially supported by ZonMW. Grant number 90700201.

References

 

DC FieldValueLanguage
dc.contributor.authorBroeze, KAen_HK
dc.contributor.authorOpmeer, BCen_HK
dc.contributor.authorVan geloven, Nen_HK
dc.contributor.authorCoppus, SFPJen_HK
dc.contributor.authorCollins, JAen_HK
dc.contributor.authorDen hartog, JEen_HK
dc.contributor.authorVan der Linden, PJQen_HK
dc.contributor.authorMarianowski, Pen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorVan der Steeg, JWen_HK
dc.contributor.authorSteures, Pen_HK
dc.contributor.authorStrandell, Aen_HK
dc.contributor.authorVan der Veen, Fen_HK
dc.contributor.authorMol, BWJen_HK
dc.date.accessioned2011-06-17T09:21:58Z-
dc.date.available2011-06-17T09:21:58Z-
dc.date.issued2011en_HK
dc.identifier.citationHuman Reproduction Update, 2011, v. 17 n. 3, p. 293-300en_HK
dc.identifier.issn1355-4786en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134489-
dc.description.abstractBackground: Conventional meta-analysis has estimated the sensitivity and specificity of hysterosalpingography (HSG) to be 65% and 83%. The impact of patient characteristics on the accuracy of HSG is unknown. The aim of this study was to assess by individual patient data meta-analysis whether the accuracy of HSG is associated with different patient characteristics. Methods: We approached authors of primary studies reporting on the accuracy of HSG using findings at laparoscopy as the reference. We assessed whether patient characteristics such as female age, duration of subfertility and a clinical history without risk factors for tubal pathology were associated with the accuracy of HSG, using a random intercept logistic regression model. Results: We acquired data of seven primary studies containing data of 4521 women. Pooled sensitivity and specificity of HSG were 53% and 87% for any tubal pathology and 46% and 95% for bilateral tubal pathology. In women without risk factors, the sensitivity of HSG was 38% for any tubal pathology, compared with 61% in women with risk factors (P = 0.005). For bilateral tubal pathology, these rates were 13% versus 47% (P = 0.01). For bilateral tubal pathology, the sensitivity of HSG decreased with age [factor 0.93 per year (P = 0.05)]. The specificity of HSG was very stable across all subgroups. Conclusions: The accuracy of HSG in detecting tubal pathology was similar in all subgroups, except for women without risk factors in whom sensitivity was lower, possibly due to false-positive results at laparoscopy. HSG is a useful tubal patency screening test for all infertile couples. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://humupd.oxfordjournals.orgen_HK
dc.relation.ispartofHuman Reproduction Updateen_HK
dc.subjectDiagnostic accuracyen_HK
dc.subjectHysterosalpingographyen_HK
dc.subjectIndividual patient data meta-analysisen_HK
dc.subjectSystematic reviewen_HK
dc.subjectTubal pathologyen_HK
dc.titleAre patient characteristics associated with the accuracy of hysterosalpingography in diagnosing tubal pathology? An individual patient data meta-analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-4786&volume=17&issue=3&spage=293&epage=300&date=2010&atitle=Are+patient+characteristics+associated+with+the+accuracy+of+hysterosalpingography+in+diagnosing+tubal+pathology?+An+individual+patient+data+meta-analysis-
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/humupd/dmq056en_HK
dc.identifier.pmid21147835-
dc.identifier.scopuseid_2-s2.0-79954487427en_HK
dc.identifier.hkuros185501en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79954487427&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue3en_HK
dc.identifier.spage293en_HK
dc.identifier.epage300en_HK
dc.identifier.eissn1460-2369-
dc.identifier.isiWOS:000289312300001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBroeze, KA=14218851000en_HK
dc.identifier.scopusauthoridOpmeer, BC=6603316333en_HK
dc.identifier.scopusauthoridVan geloven, N=26636188600en_HK
dc.identifier.scopusauthoridCoppus, SFPJ=14832256300en_HK
dc.identifier.scopusauthoridCollins, JA=7404950700en_HK
dc.identifier.scopusauthoridDen hartog, JE=24472947600en_HK
dc.identifier.scopusauthoridVan der Linden, PJQ=7006186214en_HK
dc.identifier.scopusauthoridMarianowski, P=14030363000en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridVan der Steeg, JW=6603108697en_HK
dc.identifier.scopusauthoridSteures, P=6603289741en_HK
dc.identifier.scopusauthoridStrandell, A=7003357282en_HK
dc.identifier.scopusauthoridVan der Veen, F=7005110784en_HK
dc.identifier.scopusauthoridMol, BWJ=35885117500en_HK

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