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Article: Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors

TitleCoiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors
Authors
Issue Date2000
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aid
Citation
Aids Research And Human Retroviruses, 2000, v. 16 n. 16, p. 1689-1694 How to Cite?
AbstractHuman T lymphotropic virus type 1 (HTLV-1) Tax is a multifunctional protein centrally involved in transcriptional regulation, cell cycle control, and viral transformation. The regulatory functions of Tax are thought to be mediated through protein-protein interaction with cellular cofactors. Previously we have identified several novel binding partners for Tax, including human mitotic checkpoint protein MAD1 (TXBP181), G-protein pathway suppressor GPS2 (TXBP31), and IκB kinase regulatory subunit IKK-γ. Here we described two additional Tax partners, TXBP151 and TXBP121. A closer examination of the sequences of eight independent cellular Tax-binding proteins identified by us and others revealed that all of them share a single characteristic, a highly structured coiled-coil domain. We also noted that Tax and the Tax-binding coiled-coil proteins can homodimerize. Additionally, the same domain in Tax is responsible for interaction with different coiled-coil proteins. Taken together, our findings point to a particular coiled-coil structure as one of the Tax-recognition motifs. The interaction of Tax with a particular subgroup of cellular coiled-coil proteins represents one mechanism by which Tax dysregulates cell growth and proliferation.
Persistent Identifierhttp://hdl.handle.net/10722/134154
ISSN
2015 Impact Factor: 1.949
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChun, ACSen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorJeang, KTen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2011-06-13T07:20:16Z-
dc.date.available2011-06-13T07:20:16Z-
dc.date.issued2000en_HK
dc.identifier.citationAids Research And Human Retroviruses, 2000, v. 16 n. 16, p. 1689-1694en_HK
dc.identifier.issn0889-2229en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134154-
dc.description.abstractHuman T lymphotropic virus type 1 (HTLV-1) Tax is a multifunctional protein centrally involved in transcriptional regulation, cell cycle control, and viral transformation. The regulatory functions of Tax are thought to be mediated through protein-protein interaction with cellular cofactors. Previously we have identified several novel binding partners for Tax, including human mitotic checkpoint protein MAD1 (TXBP181), G-protein pathway suppressor GPS2 (TXBP31), and IκB kinase regulatory subunit IKK-γ. Here we described two additional Tax partners, TXBP151 and TXBP121. A closer examination of the sequences of eight independent cellular Tax-binding proteins identified by us and others revealed that all of them share a single characteristic, a highly structured coiled-coil domain. We also noted that Tax and the Tax-binding coiled-coil proteins can homodimerize. Additionally, the same domain in Tax is responsible for interaction with different coiled-coil proteins. Taken together, our findings point to a particular coiled-coil structure as one of the Tax-recognition motifs. The interaction of Tax with a particular subgroup of cellular coiled-coil proteins represents one mechanism by which Tax dysregulates cell growth and proliferation.en_HK
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aiden_HK
dc.relation.ispartofAIDS Research and Human Retrovirusesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [AIDS Research and Human Retroviruses] © [2000] [copyright Mary Ann Liebert, Inc.]; [AIDS Research and Human Retroviruses] is available online at: http://www.liebertonline.com.-
dc.subject.meshAmino Acid Motifsen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshCarrier Proteins - chemistry - genetics - metabolismen_HK
dc.subject.meshCell Cycle Proteinsen_HK
dc.subject.meshDimerizationen_HK
dc.subject.meshGene Products, tax - chemistry - genetics - metabolismen_HK
dc.subject.meshHuman T-lymphotropic virus 1 - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshI-kappa B Kinaseen_HK
dc.subject.meshIntracellular Signaling Peptides and Proteinsen_HK
dc.subject.meshMutationen_HK
dc.subject.meshNeoplasm Proteinsen_HK
dc.subject.meshNuclear Proteinsen_HK
dc.subject.meshPhosphoproteins - chemistry - genetics - metabolismen_HK
dc.subject.meshPlasmids - geneticsen_HK
dc.subject.meshProtein-Serine-Threonine Kinases - chemistry - metabolismen_HK
dc.subject.meshRepressor Proteins - chemistry - genetics - metabolismen_HK
dc.subject.meshStructure-Activity Relationshipen_HK
dc.subject.meshTwo-Hybrid System Techniquesen_HK
dc.titleCoiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactorsen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, CM:wispwong@hkucc.hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityWong, CM=rp01489en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1089/08892220050193155en_HK
dc.identifier.pmid11080811-
dc.identifier.scopuseid_2-s2.0-0034332197en_HK
dc.identifier.hkuros60384-
dc.identifier.hkuros53981-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034332197&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue16en_HK
dc.identifier.spage1689en_HK
dc.identifier.epage1694en_HK
dc.identifier.isiWOS:000165324900018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChun, ACS=7003650706en_HK
dc.identifier.scopusauthoridZhou, Y=7405366890en_HK
dc.identifier.scopusauthoridWong, CM=18134632400en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridJeang, KT=7004824803en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK

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