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Conference Paper: Systematic review and meta-analysis of pulmonary valve replacement in children and adults after surgical repair of tetralogy of fallot
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TitleSystematic review and meta-analysis of pulmonary valve replacement in children and adults after surgical repair of tetralogy of fallot
 
AuthorsCheung, YF
Cheung, EWY
Wong, WHS
 
KeywordsMeta-analysis
Pulmonary valve replacement
Tetralogy of fallot
 
Issue Date2010
 
CitationThe 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association. Taipei, Taiwan, 15-18 April 2010. [How to Cite?]
 
AbstractOBJECTIVES: Reported outcomes of surgical PVR in children and adults after TOF repair were based on relatively small observational studies. This systematic review and meta-analysis aimed to determine the outcomes and impact on right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot (TOF). METHODS: The PubMed database was searched from its inception to April 2009. Observational studies reporting on the following outcomes measures after surgical PVR were reviewed: early and late all-cause mortalities, redo-PVR rate, and changes in indexed RV volumes, ejection fraction (EF), and QRS duration after PVR. RESULTS: Of the 305 citations screened, 15 met the criteria and were analyzed. Pooled early mortality (n=595) was 2.1% (95% CI, 1.1 to 4.0%). Late mortality rate was 0.5%/patient-year (95% CI, 0.2 to 0.8%/patient-year) and redo-PVR rate was 1.9%/patient-year (95% CI, 1.3 to 2.5%/patient-year). Data on RV volumes and ejection fractions were available from 5 studies (n=141). Pooled mean differences of indexed RV end-diastolic and end-systolic volumes were -64ml/m2 (95% CI, -55 to -72ml/m2) and -37ml/m2 (95% CI, -30 to -45ml/m2), respectively. No significant changes in pooled mean difference of RV EF (95% CI, -3 to 1%) and QRS duration (95%CI, -1 to 12ms) were observed. CONCLUSIONS: Surgical PVR in patients after TOF repair is associated with low early and late mortalities and significant decrease in RV volumes, but with no changes in RV EF or QRS duration.
 
DescriptionOral presentation: FP8-03
 
DC FieldValue
dc.contributor.authorCheung, YF
 
dc.contributor.authorCheung, EWY
 
dc.contributor.authorWong, WHS
 
dc.date.accessioned2011-06-10T08:48:22Z
 
dc.date.available2011-06-10T08:48:22Z
 
dc.date.issued2010
 
dc.description.abstractOBJECTIVES: Reported outcomes of surgical PVR in children and adults after TOF repair were based on relatively small observational studies. This systematic review and meta-analysis aimed to determine the outcomes and impact on right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot (TOF). METHODS: The PubMed database was searched from its inception to April 2009. Observational studies reporting on the following outcomes measures after surgical PVR were reviewed: early and late all-cause mortalities, redo-PVR rate, and changes in indexed RV volumes, ejection fraction (EF), and QRS duration after PVR. RESULTS: Of the 305 citations screened, 15 met the criteria and were analyzed. Pooled early mortality (n=595) was 2.1% (95% CI, 1.1 to 4.0%). Late mortality rate was 0.5%/patient-year (95% CI, 0.2 to 0.8%/patient-year) and redo-PVR rate was 1.9%/patient-year (95% CI, 1.3 to 2.5%/patient-year). Data on RV volumes and ejection fractions were available from 5 studies (n=141). Pooled mean differences of indexed RV end-diastolic and end-systolic volumes were -64ml/m2 (95% CI, -55 to -72ml/m2) and -37ml/m2 (95% CI, -30 to -45ml/m2), respectively. No significant changes in pooled mean difference of RV EF (95% CI, -3 to 1%) and QRS duration (95%CI, -1 to 12ms) were observed. CONCLUSIONS: Surgical PVR in patients after TOF repair is associated with low early and late mortalities and significant decrease in RV volumes, but with no changes in RV EF or QRS duration.
 
dc.descriptionOral presentation: FP8-03
 
dc.description.otherThe 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association. Taipei, Taiwan, 15-18 April 2010.
 
dc.identifier.citationThe 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association. Taipei, Taiwan, 15-18 April 2010. [How to Cite?]
 
dc.identifier.hkuros169728
 
dc.identifier.urihttp://hdl.handle.net/10722/133938
 
dc.languageeng
 
dc.relation.ispartofCongress of Asian Society for Pediatric Research
 
dc.relation.ispartofAnnual Meeting of Taiwan Pediatric Association
 
dc.subjectMeta-analysis
 
dc.subjectPulmonary valve replacement
 
dc.subjectTetralogy of fallot
 
dc.titleSystematic review and meta-analysis of pulmonary valve replacement in children and adults after surgical repair of tetralogy of fallot
 
dc.typeConference_Paper
 
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<item><contributor.author>Cheung, YF</contributor.author>
<contributor.author>Cheung, EWY</contributor.author>
<contributor.author>Wong, WHS</contributor.author>
<date.accessioned>2011-06-10T08:48:22Z</date.accessioned>
<date.available>2011-06-10T08:48:22Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>The 6th Congress of Asian Society for Pediatric Research &amp; 51st Annual Meeting of Taiwan Pediatric Association. Taipei, Taiwan, 15-18 April 2010.</identifier.citation>
<identifier.uri>http://hdl.handle.net/10722/133938</identifier.uri>
<description>Oral presentation: FP8-03</description>
<description.abstract>OBJECTIVES: Reported outcomes of surgical PVR in children and adults after TOF repair were based on relatively small observational studies. This systematic review and meta-analysis aimed to determine the outcomes and impact on right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot (TOF). METHODS: The PubMed database was searched from its inception to April 2009. Observational studies reporting on the following outcomes measures after surgical PVR were reviewed: early and late all-cause mortalities, redo-PVR rate, and changes in indexed RV volumes, ejection fraction (EF), and QRS duration after PVR. RESULTS: Of the 305 citations screened, 15 met the criteria and were analyzed. Pooled early mortality (n=595) was 2.1% (95% CI, 1.1 to 4.0%). Late mortality rate was 0.5%/patient-year (95% CI, 0.2 to 0.8%/patient-year) and redo-PVR rate was 1.9%/patient-year (95% CI, 1.3 to 2.5%/patient-year). Data on RV volumes and ejection fractions were available from 5 studies (n=141). Pooled mean differences of indexed RV end-diastolic and end-systolic volumes were -64ml/m2 (95% CI, -55 to -72ml/m2) and -37ml/m2 (95% CI, -30 to -45ml/m2), respectively. No significant changes in pooled mean difference of RV EF (95% CI, -3 to 1%) and QRS duration (95%CI, -1 to 12ms) were observed. CONCLUSIONS: Surgical PVR in patients after TOF repair is associated with low early and late mortalities and significant decrease in RV volumes, but with no changes in RV EF or QRS duration.</description.abstract>
<language>eng</language>
<relation.ispartof>Congress of Asian Society for Pediatric Research</relation.ispartof>
<relation.ispartof>Annual Meeting of Taiwan Pediatric Association</relation.ispartof>
<subject>Meta-analysis</subject>
<subject>Pulmonary valve replacement</subject>
<subject>Tetralogy of fallot</subject>
<title>Systematic review and meta-analysis of pulmonary valve replacement in children and adults after surgical repair of tetralogy of fallot</title>
<type>Conference_Paper</type>
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<description.other>The 6th Congress of Asian Society for Pediatric Research &amp; 51st Annual Meeting of Taiwan Pediatric Association. Taipei, Taiwan, 15-18 April 2010.</description.other>
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