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Article: Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B

TitleReduction of liver stiffness following resolution of acute flares of chronic hepatitis B
Authors
KeywordsFibroscan
Fibrosis
Flare
Hepatitis B
Liver stiffness
Transient elastography
Issue Date2010
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0
Citation
Hepatology International, 2010, v. 4 n. 4, p. 716-722 How to Cite?
AbstractBackground: Measuring liver stiffness is becoming more popular as a non-invasive tool for assessing liver fibrosis. Aim: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors that correlate with liver stiffness measurements. Methods: Twenty-nine patients with severe hepatitis B flare (ALT > 10 × upper limit of normal) were followed up for 1 year. Serial transient elastography was performed at the time of flare, 3-6, and 12 months after flare. Results: At the time of flare, the median liver stiffness was 16.8 kPa, with no patients having normal liver stiffness (<6 kPa). There was a significant decrease in liver stiffness from baseline to 3-6 months (16.8 vs. 7.9 kPa, respectively, P < 0.001), and a further smaller decline from 3-6 to 12 months (7.9 vs. 6.9 kPa, respectively, P = 0.039). By 12 months, 10 (34%) had normalized their liver stiffness. Baseline parameters which correlated with liver stiffness include bilirubin, ALT, albumin, prothrombin time and platelet levels (all P < 0.05). Conclusion: Liver stiffness was increased in patients with severe hepatitis B flares, with return to near normal levels by 6 months. Transient elastography for proper assessment of liver fibrosis should be performed at least 6 months after flare. © 2010 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/133804
ISSN
2015 Impact Factor: 1.125
2015 SCImago Journal Rankings: 0.669
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFung, Jen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorBut, Den_HK
dc.contributor.authorHsu, Aen_HK
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorCheng, Cen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2011-05-31T06:51:36Z-
dc.date.available2011-05-31T06:51:36Z-
dc.date.issued2010en_HK
dc.identifier.citationHepatology International, 2010, v. 4 n. 4, p. 716-722en_HK
dc.identifier.issn1936-0533en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133804-
dc.description.abstractBackground: Measuring liver stiffness is becoming more popular as a non-invasive tool for assessing liver fibrosis. Aim: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors that correlate with liver stiffness measurements. Methods: Twenty-nine patients with severe hepatitis B flare (ALT > 10 × upper limit of normal) were followed up for 1 year. Serial transient elastography was performed at the time of flare, 3-6, and 12 months after flare. Results: At the time of flare, the median liver stiffness was 16.8 kPa, with no patients having normal liver stiffness (<6 kPa). There was a significant decrease in liver stiffness from baseline to 3-6 months (16.8 vs. 7.9 kPa, respectively, P < 0.001), and a further smaller decline from 3-6 to 12 months (7.9 vs. 6.9 kPa, respectively, P = 0.039). By 12 months, 10 (34%) had normalized their liver stiffness. Baseline parameters which correlated with liver stiffness include bilirubin, ALT, albumin, prothrombin time and platelet levels (all P < 0.05). Conclusion: Liver stiffness was increased in patients with severe hepatitis B flares, with return to near normal levels by 6 months. Transient elastography for proper assessment of liver fibrosis should be performed at least 6 months after flare. © 2010 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0en_HK
dc.relation.ispartofHepatology Internationalen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFibroscanen_HK
dc.subjectFibrosisen_HK
dc.subjectFlareen_HK
dc.subjectHepatitis Ben_HK
dc.subjectLiver stiffnessen_HK
dc.subjectTransient elastographyen_HK
dc.titleReduction of liver stiffness following resolution of acute flares of chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.emailFung, J: jfung@sicklehut.comen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailSeto, WK: wkseto2@hku.hken_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s12072-010-9189-zen_HK
dc.identifier.pmid21286342-
dc.identifier.pmcidPMC2978896-
dc.identifier.scopuseid_2-s2.0-78649488376en_HK
dc.identifier.hkuros189974-
dc.identifier.hkuros213681-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649488376&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue4en_HK
dc.identifier.spage716en_HK
dc.identifier.epage722en_HK
dc.identifier.eissn1936-0541en_US
dc.identifier.isiWOS:000284161600007-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 31 May 2011en_US
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridBut, D=24343113400en_HK
dc.identifier.scopusauthoridHsu, A=16204995400en_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK
dc.identifier.scopusauthoridCheng, C=24802108600en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.citeulike7618505-

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