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Article: A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung

TitleA novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung
Authors
KeywordsMolecular Sequence Numbers
Issue Date2007
PublisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
Citation
Journal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536 How to Cite?
AbstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.
Persistent Identifierhttp://hdl.handle.net/10722/132493
ISSN
2014 Impact Factor: 12.515
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorXu, Xen_HK
dc.contributor.authorTo, LYFen_HK
dc.contributor.authorHuang, FPen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorLin, CLSen_HK
dc.date.accessioned2011-03-28T09:25:22Z-
dc.date.available2011-03-28T09:25:22Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536en_HK
dc.identifier.issn0022-1007en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132493-
dc.description.abstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.en_HK
dc.languageengen_US
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jem.orgen_HK
dc.relation.ispartofJournal of Experimental Medicineen_HK
dc.subjectMolecular Sequence Numbersen_US
dc.titleA novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lungen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, VSF: sfvchan@hku.hken_HK
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_HK
dc.identifier.emailChan, KYK: kelvinc@pathology.hku.hken_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.authorityChan, KYK=rp00453en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1084/jem.20070462en_HK
dc.identifier.pmid17923501-
dc.identifier.pmcidPMC2118498-
dc.identifier.scopuseid_2-s2.0-35748954658en_HK
dc.identifier.hkuros138878-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35748954658&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume204en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2529en_HK
dc.identifier.epage2536en_HK
dc.identifier.eissn1540-9538-
dc.identifier.isiWOS:000250652200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, Y=16416830300en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridChan, KYK=7406034195en_HK
dc.identifier.scopusauthoridXu, X=9276575900en_HK
dc.identifier.scopusauthoridTo, LYF=22954631200en_HK
dc.identifier.scopusauthoridHuang, FP=35358818300en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridLin, CLS=37099293900en_HK

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