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Article: A novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung

TitleA novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung
Authors
KeywordsMolecular Sequence Numbers
Issue Date2007
PublisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
Citation
Journal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536 How to Cite?
Abstract
Identification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.
Persistent Identifierhttp://hdl.handle.net/10722/132493
ISSN
2013 Impact Factor: 13.912
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Hammersmith Hospital
  3. The University of Hong Kong
  4. Weatherall Institute of Molecular Medicine
DC FieldValueLanguage
dc.contributor.authorChen, Yen_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorXu, Xen_HK
dc.contributor.authorTo, LYFen_HK
dc.contributor.authorHuang, FPen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorLin, CLSen_HK
dc.date.accessioned2011-03-28T09:25:22Z-
dc.date.available2011-03-28T09:25:22Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536en_HK
dc.identifier.issn0022-1007en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132493-
dc.description.abstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.en_HK
dc.languageengen_US
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jem.orgen_HK
dc.relation.ispartofJournal of Experimental Medicineen_HK
dc.subjectMolecular Sequence Numbersen_US
dc.titleA novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lungen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, VSF: sfvchan@hku.hken_HK
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_HK
dc.identifier.emailChan, KYK: kelvinc@pathology.hku.hken_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.authorityChan, KYK=rp00453en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1084/jem.20070462en_HK
dc.identifier.pmid17923501en_HK
dc.identifier.pmcidPMC2118498-
dc.identifier.scopuseid_2-s2.0-35748954658en_HK
dc.identifier.hkuros138878-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35748954658&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume204en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2529en_HK
dc.identifier.epage2536en_HK
dc.identifier.eissn1540-9538-
dc.identifier.isiWOS:000250652200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, Y=16416830300en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridChan, KYK=7406034195en_HK
dc.identifier.scopusauthoridXu, X=9276575900en_HK
dc.identifier.scopusauthoridTo, LYF=22954631200en_HK
dc.identifier.scopusauthoridHuang, FP=35358818300en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridLin, CLS=37099293900en_HK

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