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Article: A novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung
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TitleA novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung
 
AuthorsChen, Y3 2
Chan, VSF3 2
Zheng, B3
Chan, KYK1
Xu, X4
To, LYF3 2
Huang, FP2
Khoo, US1
Lin, CLS3 2
 
KeywordsMolecular Sequence Numbers
 
Issue Date2007
 
PublisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
 
CitationJournal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536 [How to Cite?]
DOI: http://dx.doi.org/10.1084/jem.20070462
 
AbstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.
 
ISSN0022-1007
2012 Impact Factor: 13.214
2012 SCImago Journal Rankings: 9.915
 
DOIhttp://dx.doi.org/10.1084/jem.20070462
 
PubMed Central IDPMC2118498
 
ISI Accession Number IDWOS:000250652200006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, Y
 
dc.contributor.authorChan, VSF
 
dc.contributor.authorZheng, B
 
dc.contributor.authorChan, KYK
 
dc.contributor.authorXu, X
 
dc.contributor.authorTo, LYF
 
dc.contributor.authorHuang, FP
 
dc.contributor.authorKhoo, US
 
dc.contributor.authorLin, CLS
 
dc.date.accessioned2011-03-28T09:25:22Z
 
dc.date.available2011-03-28T09:25:22Z
 
dc.date.issued2007
 
dc.description.abstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationJournal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536 [How to Cite?]
DOI: http://dx.doi.org/10.1084/jem.20070462
 
dc.identifier.doihttp://dx.doi.org/10.1084/jem.20070462
 
dc.identifier.eissn1540-9538
 
dc.identifier.epage2536
 
dc.identifier.hkuros138878
 
dc.identifier.isiWOS:000250652200006
 
dc.identifier.issn0022-1007
2012 Impact Factor: 13.214
2012 SCImago Journal Rankings: 9.915
 
dc.identifier.issue11
 
dc.identifier.pmcidPMC2118498
 
dc.identifier.pmid17923501
 
dc.identifier.scopuseid_2-s2.0-35748954658
 
dc.identifier.spage2529
 
dc.identifier.urihttp://hdl.handle.net/10722/132493
 
dc.identifier.volume204
 
dc.languageeng
 
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Experimental Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subjectMolecular Sequence Numbers
 
dc.titleA novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung
 
dc.typeArticle
 
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<contributor.author>Xu, X</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Hammersmith Hospital
  3. The University of Hong Kong
  4. Weatherall Institute of Molecular Medicine