Article: A novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung

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TitleA novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung
AuthorsChen, Y2 3
Chan, VSF2 3
Zheng, B3
Chan, KYK1
Xu, X4
To, LYF2 3
Huang, FP2
Khoo, US1
Lin, CLS2 3
KeywordsMolecular Sequence Numbers
Issue Date2007
PublisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
CitationJournal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536 [How to Cite?]
DOI: http://dx.doi.org/10.1084/jem.20070462
AbstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.
ISSN0022-1007
2011 Impact Factor: 13.853
2011 SCImago Journal Rankings: 4.186
DOIhttp://dx.doi.org/10.1084/jem.20070462
ISI Accession Number IDWOS:000250652200006
PubMed Central IDPMC2118498
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChen, Y
dc.contributor.authorChan, VSF
dc.contributor.authorZheng, B
dc.contributor.authorChan, KYK
dc.contributor.authorXu, X
dc.contributor.authorTo, LYF
dc.contributor.authorHuang, FP
dc.contributor.authorKhoo, US
dc.contributor.authorLin, CLS
dc.date.accessioned2011-03-28T09:25:22Z
dc.date.available2011-03-28T09:25:22Z
dc.date.issued2007
dc.description.abstractIdentification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS + cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed. JEM © The Rockefeller University Press.
dc.description.naturepublished_or_final_version
dc.identifier.citationJournal Of Experimental Medicine, 2007, v. 204 n. 11, p. 2529-2536 [How to Cite?]
DOI: http://dx.doi.org/10.1084/jem.20070462
dc.identifier.doihttp://dx.doi.org/10.1084/jem.20070462
dc.identifier.epage2536
dc.identifier.hkuros138878
dc.identifier.isiWOS:000250652200006
dc.identifier.issn0022-1007
2011 Impact Factor: 13.853
2011 SCImago Journal Rankings: 4.186
dc.identifier.issue11
dc.identifier.pmcidPMC2118498
dc.identifier.pmid17923501
dc.identifier.scopuseid_2-s2.0-35748954658
dc.identifier.spage2529
dc.identifier.urihttp://hdl.handle.net/10722/132493
dc.identifier.volume204
dc.languageeng
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Experimental Medicine
dc.relation.referencesReferences in Scopus
dc.subjectMolecular Sequence Numbers
dc.titleA novel subset of putative stem/progenitor CD34 + Oct-4 + cells is the major target for SARS coronavirus in human lung
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Hammersmith Hospital
  3. The University of Hong Kong
  4. Weatherall Institute of Molecular Medicine