Article: CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
| Title | CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Chan, KYK1 Xu, MS1 Ching, JCY1 So, TMK2 Lai, ST2 Chu, CM5 Yam, LYC4 Wong, ATY6 Chung, PH Chan, VSF3 Lin, CLS3 Sham, PC1 Leung, GM1 Peiris, JSM1 Khoo, US1 | ||||||
| Keywords | CD209 DC-SIGN Lactate dehydrogenase SARS SNP | ||||||
| Issue Date | 2010 | ||||||
| Publisher | Elsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/humimm | ||||||
| Citation | Human Immunology, 2010, v. 71 n. 7, p. 702-707 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.humimm.2010.03.006 | ||||||
| Abstract | CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating. © 2010 American Society for Histocompatibility and Immunogenetics. | ||||||
| ISSN | 0198-8859 2011 Impact Factor: 2.837 2011 SCImago Journal Rankings: 0.317 | ||||||
| DOI | http://dx.doi.org/10.1016/j.humimm.2010.03.006 | ||||||
| ISI Accession Number ID | WOS:000279493000009
Funding Information: We thank Drs. Vivian Wong and Jane Chan and Edwina Shung (Hospital Authority SARS Collaborative Group) for the retrieval of clinical data of patients with SARS from the central database. This study was supported by Research Fund for the Control of Infectious Diseases (Project 04050252), Food and Health Bureau, Hong Kong SAR, China. | ||||||
| References | References in Scopus | ||||||
| Grants | Promoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection |
| dc.contributor.author | Chan, KYK | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Xu, MS | ||||||
| dc.contributor.author | Ching, JCY | ||||||
| dc.contributor.author | So, TMK | ||||||
| dc.contributor.author | Lai, ST | ||||||
| dc.contributor.author | Chu, CM | ||||||
| dc.contributor.author | Yam, LYC | ||||||
| dc.contributor.author | Wong, ATY | ||||||
| dc.contributor.author | Chung, PH | ||||||
| dc.contributor.author | Chan, VSF | ||||||
| dc.contributor.author | Lin, CLS | ||||||
| dc.contributor.author | Sham, PC | ||||||
| dc.contributor.author | Leung, GM | ||||||
| dc.contributor.author | Peiris, JSM | ||||||
| dc.contributor.author | Khoo, US | ||||||
| dc.date.accessioned | 2011-03-28T09:25:19Z | ||||||
| dc.date.available | 2011-03-28T09:25:19Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating. © 2010 American Society for Histocompatibility and Immunogenetics. | ||||||
| dc.description.grant | Promoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection | ||||||
| dc.description.grantcode | 81838 | ||||||
| dc.description.nature | link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Human Immunology, 2010, v. 71 n. 7, p. 702-707 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.humimm.2010.03.006 | ||||||
| dc.identifier.citeulike | 7064028 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.humimm.2010.03.006 | ||||||
| dc.identifier.epage | 707 | ||||||
| dc.identifier.isi | WOS:000279493000009
Funding Information: We thank Drs. Vivian Wong and Jane Chan and Edwina Shung (Hospital Authority SARS Collaborative Group) for the retrieval of clinical data of patients with SARS from the central database. This study was supported by Research Fund for the Control of Infectious Diseases (Project 04050252), Food and Health Bureau, Hong Kong SAR, China. | ||||||
| dc.identifier.issn | 0198-8859 2011 Impact Factor: 2.837 2011 SCImago Journal Rankings: 0.317 | ||||||
| dc.identifier.issue | 7 | ||||||
| dc.identifier.pmid | 20359516 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77953917346 | ||||||
| dc.identifier.spage | 702 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/132488 | ||||||
| dc.identifier.volume | 71 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/humimm | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Human Immunology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Adult | ||||||
| dc.subject.mesh | Antigens, CD - genetics | ||||||
| dc.subject.mesh | Asian Continental Ancestry Group - genetics | ||||||
| dc.subject.mesh | Cell Adhesion Molecules - genetics - metabolism | ||||||
| dc.subject.mesh | DNA - metabolism | ||||||
| dc.subject.mesh | DNA Probes - genetics | ||||||
| dc.subject.mesh | Electrophoretic Mobility Shift Assay | ||||||
| dc.subject.mesh | Female | ||||||
| dc.subject.mesh | Gene Frequency - genetics | ||||||
| dc.subject.mesh | Genotype | ||||||
| dc.subject.mesh | HeLa Cells | ||||||
| dc.subject.mesh | Heterozygote | ||||||
| dc.subject.mesh | Homozygote | ||||||
| dc.subject.mesh | Hong Kong | ||||||
| dc.subject.mesh | Humans | ||||||
| dc.subject.mesh | L-Lactate Dehydrogenase - blood | ||||||
| dc.subject.mesh | Lectins, C-Type - genetics - metabolism | ||||||
| dc.subject.mesh | Male | ||||||
| dc.subject.mesh | Middle Aged | ||||||
| dc.subject.mesh | Nuclear Proteins - metabolism | ||||||
| dc.subject.mesh | Polymorphism, Single Nucleotide - genetics | ||||||
| dc.subject.mesh | Promoter Regions, Genetic - genetics | ||||||
| dc.subject.mesh | Protein Binding - genetics | ||||||
| dc.subject.mesh | Receptors, Cell Surface - genetics - metabolism | ||||||
| dc.subject.mesh | Severe Acute Respiratory Syndrome - blood - genetics | ||||||
| dc.subject.mesh | Sp1 Transcription Factor - genetics | ||||||
| dc.subject.mesh | Transcription Factor AP-2 - genetics | ||||||
| dc.subject.mesh | Transfection | ||||||
| dc.subject | CD209 | ||||||
| dc.subject | DC-SIGN | ||||||
| dc.subject | Lactate dehydrogenase | ||||||
| dc.subject | SARS | ||||||
| dc.subject | SNP | ||||||
| dc.title | CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- Princess Margaret Hospital Hong Kong
- Imperial College London
- Pamela Youde Nethersole Eastern Hospital
- United Christian Hospital Hong Kong
- Centre for Health Protection