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Article: CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese

TitleCD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
Authors
KeywordsCD209
DC-SIGN
Lactate dehydrogenase
SARS
SNP
Issue Date2010
PublisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/humimm
Citation
Human Immunology, 2010, v. 71 n. 7, p. 702-707 How to Cite?
Abstract
CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating. © 2010 American Society for Histocompatibility and Immunogenetics.
Persistent Identifierhttp://hdl.handle.net/10722/132488
ISSN
2013 Impact Factor: 2.282
2013 SCImago Journal Rankings: 0.920
ISI Accession Number ID
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases04050252
Food and Health Bureau, Hong Kong SAR, China
Funding Information:

We thank Drs. Vivian Wong and Jane Chan and Edwina Shung (Hospital Authority SARS Collaborative Group) for the retrieval of clinical data of patients with SARS from the central database. This study was supported by Research Fund for the Control of Infectious Diseases (Project 04050252), Food and Health Bureau, Hong Kong SAR, China.

References
Grants

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Princess Margaret Hospital Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. United Christian Hospital Hong Kong
  5. Imperial College London
  6. Centre for Health Protection
DC FieldValueLanguage
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorXu, MSen_HK
dc.contributor.authorChing, JCYen_HK
dc.contributor.authorSo, TMKen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorChu, CMen_HK
dc.contributor.authorYam, LYCen_HK
dc.contributor.authorWong, ATYen_HK
dc.contributor.authorChung, PHen_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorLin, CLSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorKhoo, USen_HK
dc.date.accessioned2011-03-28T09:25:19Z-
dc.date.available2011-03-28T09:25:19Z-
dc.date.issued2010en_HK
dc.identifier.citationHuman Immunology, 2010, v. 71 n. 7, p. 702-707en_HK
dc.identifier.issn0198-8859en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132488-
dc.description.abstractCD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating. © 2010 American Society for Histocompatibility and Immunogenetics.en_HK
dc.languageengen_US
dc.publisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/humimmen_HK
dc.relation.ispartofHuman Immunologyen_HK
dc.subjectCD209en_HK
dc.subjectDC-SIGNen_HK
dc.subjectLactate dehydrogenaseen_HK
dc.subjectSARSen_HK
dc.subjectSNPen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntigens, CD - geneticsen_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshCell Adhesion Molecules - genetics - metabolismen_HK
dc.subject.meshDNA - metabolismen_HK
dc.subject.meshDNA Probes - geneticsen_HK
dc.subject.meshElectrophoretic Mobility Shift Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequency - geneticsen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHeLa Cellsen_HK
dc.subject.meshHeterozygoteen_HK
dc.subject.meshHomozygoteen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshL-Lactate Dehydrogenase - blooden_HK
dc.subject.meshLectins, C-Type - genetics - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNuclear Proteins - metabolismen_HK
dc.subject.meshPolymorphism, Single Nucleotide - geneticsen_HK
dc.subject.meshPromoter Regions, Genetic - geneticsen_HK
dc.subject.meshProtein Binding - geneticsen_HK
dc.subject.meshReceptors, Cell Surface - genetics - metabolismen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - blood - geneticsen_HK
dc.subject.meshSp1 Transcription Factor - geneticsen_HK
dc.subject.meshTranscription Factor AP-2 - geneticsen_HK
dc.subject.meshTransfectionen_HK
dc.titleCD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, KYK: kelvinc@pathology.hku.hken_HK
dc.identifier.emailChan, VSF: sfvchan@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.authorityChan, KYK=rp00453en_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.humimm.2010.03.006en_HK
dc.identifier.pmid20359516en_HK
dc.identifier.scopuseid_2-s2.0-77953917346en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953917346&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue7en_HK
dc.identifier.spage702en_HK
dc.identifier.epage707en_HK
dc.identifier.isiWOS:000279493000009-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectPromoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection-
dc.identifier.scopusauthoridChan, KYK=7406034195en_HK
dc.identifier.scopusauthoridXu, MS=35957113100en_HK
dc.identifier.scopusauthoridChing, JCY=15735635300en_HK
dc.identifier.scopusauthoridSo, TMK=7005305634en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridChu, CM=7404345558en_HK
dc.identifier.scopusauthoridYam, LYC=7102764741en_HK
dc.identifier.scopusauthoridWong, ATY=36921624400en_HK
dc.identifier.scopusauthoridChung, PH=9336467200en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridLin, CLS=37099293900en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.citeulike7064028-

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