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Article: CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
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TitleCD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
 
AuthorsChan, KYK1
Xu, MS1
Ching, JCY1
So, TMK2
Lai, ST2
Chu, CM4
Yam, LYC3
Wong, ATY6
Chung, PH
Chan, VSF5
Lin, CLS5
Sham, PC1
Leung, GM1
Peiris, JSM1
Khoo, US1
 
KeywordsCD209
DC-SIGN
Lactate dehydrogenase
SARS
SNP
 
Issue Date2010
 
PublisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/humimm
 
CitationHuman Immunology, 2010, v. 71 n. 7, p. 702-707 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.humimm.2010.03.006
 
AbstractCD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating. © 2010 American Society for Histocompatibility and Immunogenetics.
 
ISSN0198-8859
2012 Impact Factor: 2.298
2012 SCImago Journal Rankings: 0.817
 
DOIhttp://dx.doi.org/10.1016/j.humimm.2010.03.006
 
ISI Accession Number IDWOS:000279493000009
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases04050252
Food and Health Bureau, Hong Kong SAR, China
Funding Information:

We thank Drs. Vivian Wong and Jane Chan and Edwina Shung (Hospital Authority SARS Collaborative Group) for the retrieval of clinical data of patients with SARS from the central database. This study was supported by Research Fund for the Control of Infectious Diseases (Project 04050252), Food and Health Bureau, Hong Kong SAR, China.

 
ReferencesReferences in Scopus
 
GrantsPromoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection
 
DC FieldValue
dc.contributor.authorChan, KYK
 
dc.contributor.authorXu, MS
 
dc.contributor.authorChing, JCY
 
dc.contributor.authorSo, TMK
 
dc.contributor.authorLai, ST
 
dc.contributor.authorChu, CM
 
dc.contributor.authorYam, LYC
 
dc.contributor.authorWong, ATY
 
dc.contributor.authorChung, PH
 
dc.contributor.authorChan, VSF
 
dc.contributor.authorLin, CLS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLeung, GM
 
dc.contributor.authorPeiris, JSM
 
dc.contributor.authorKhoo, US
 
dc.date.accessioned2011-03-28T09:25:19Z
 
dc.date.available2011-03-28T09:25:19Z
 
dc.date.issued2010
 
dc.description.abstractCD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating. © 2010 American Society for Histocompatibility and Immunogenetics.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHuman Immunology, 2010, v. 71 n. 7, p. 702-707 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.humimm.2010.03.006
 
dc.identifier.citeulike7064028
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.humimm.2010.03.006
 
dc.identifier.epage707
 
dc.identifier.isiWOS:000279493000009
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases04050252
Food and Health Bureau, Hong Kong SAR, China
Funding Information:

We thank Drs. Vivian Wong and Jane Chan and Edwina Shung (Hospital Authority SARS Collaborative Group) for the retrieval of clinical data of patients with SARS from the central database. This study was supported by Research Fund for the Control of Infectious Diseases (Project 04050252), Food and Health Bureau, Hong Kong SAR, China.

 
dc.identifier.issn0198-8859
2012 Impact Factor: 2.298
2012 SCImago Journal Rankings: 0.817
 
dc.identifier.issue7
 
dc.identifier.pmid20359516
 
dc.identifier.scopuseid_2-s2.0-77953917346
 
dc.identifier.spage702
 
dc.identifier.urihttp://hdl.handle.net/10722/132488
 
dc.identifier.volume71
 
dc.languageeng
 
dc.publisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/humimm
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHuman Immunology
 
dc.relation.projectPromoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAntigens, CD - genetics
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshCell Adhesion Molecules - genetics - metabolism
 
dc.subject.meshDNA - metabolism
 
dc.subject.meshDNA Probes - genetics
 
dc.subject.meshElectrophoretic Mobility Shift Assay
 
dc.subject.meshFemale
 
dc.subject.meshGene Frequency - genetics
 
dc.subject.meshGenotype
 
dc.subject.meshHeLa Cells
 
dc.subject.meshHeterozygote
 
dc.subject.meshHomozygote
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshL-Lactate Dehydrogenase - blood
 
dc.subject.meshLectins, C-Type - genetics - metabolism
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNuclear Proteins - metabolism
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.subject.meshPromoter Regions, Genetic - genetics
 
dc.subject.meshProtein Binding - genetics
 
dc.subject.meshReceptors, Cell Surface - genetics - metabolism
 
dc.subject.meshSevere Acute Respiratory Syndrome - blood - genetics
 
dc.subject.meshSp1 Transcription Factor - genetics
 
dc.subject.meshTranscription Factor AP-2 - genetics
 
dc.subject.meshTransfection
 
dc.subjectCD209
 
dc.subjectDC-SIGN
 
dc.subjectLactate dehydrogenase
 
dc.subjectSARS
 
dc.subjectSNP
 
dc.titleCD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Princess Margaret Hospital Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. United Christian Hospital Hong Kong
  5. Imperial College London
  6. Centre for Health Protection