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Conference Paper: Circulating levels of biomarkers of collagen synthesis correlate with left ventricular mechanical dyssynchrony in adolescents after repair of tetralogy of fallot

TitleCirculating levels of biomarkers of collagen synthesis correlate with left ventricular mechanical dyssynchrony in adolescents after repair of tetralogy of fallot
Authors
KeywordsCongenital heart disease
Biomarkers
Collagen
Echocardiography
Ventricular remodeling
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
The 2010 Scientific Sessions of the American Heart Association (AHA), Chicago, IL., 13-17 November 2010. In Circulation, 2010, v. 122 n. 21 meeting abstracts, abstract no. 12164 How to Cite?
AbstractBACKGROUND: Abnormal remodelling of myocardial architecture may potentially lead to alteration of ventricular function in patients after repair of tetralogy of Fallot (TOF). Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are candidate biomarkers of myocardial collagen synthesis. OBJECTIVE: We tested the hypothesis that circulating levels of PICP and PIIINP may correlate with ventricular function and synchronicity of ventricular contraction in adolescents after TOF repair. METHODS: Right ventricular (RV) and left ventricular (LV) function and LV mechanical dyssynchrony were assessed by tissue Doppler and 3-dimensional echocardiography in 18 postoperative TOF patients aged 14.5±2.2 years and 11 age-matched controls. Serum PICP and plasma PIIINP levels were determined and correlated with indices of ventricular function and LV systolic dyssynchrony index (SDI). RESULTS: Compared with control, patients had significantly higher circulating PICP (482±194 μg/l vs 313±119 μg/l, p=0.015) and PIIINP (11.4±5.22 μg/l vs 7.6±3.19 μg/l, p=0.04) levels, greater RV end diastolic volume (p=0.013) with increased LV eccentricity (p<0.001), decreased RV ejection fraction (p=0.042), reduced RV IVA (p<0.001), reduced LV IVA (p=0.003), and worse LV SDI (p<0.001). Circulating PICP and PIIINP levels correlated with age (r=-0.44, p=0.016 and r=-0.58, p=0.001, respectively), body mass index (r=-0.43, p=0.019 and r=-0.50, p=0.006, respectively), and LV SDI (r=0.61, p=0.001 and r=0.47, p=0.014, respectively). Additionally, PICP levels correlated negatively with LV IVA (r=-0.42, p=0.025). Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (β=0.46, p=0.021) and PIIINP (β=0.36, p=0.034) after adjustment for age and body mass index. CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in adolescent patients after TOF repair, implicating a possible role of increased collagen synthesis in the pathogenesis of dyssynchronous LV contraction.
DescriptionCore 5. Myocardium: Function and Failure - Session Title: Biomarkers in Heart Failure: abstract A12164
Persistent Identifierhttp://hdl.handle.net/10722/129885
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorLai, CTMen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorWong, SJen_US
dc.contributor.authorChow, PCen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2010-12-23T08:43:50Z-
dc.date.available2010-12-23T08:43:50Z-
dc.date.issued2010en_US
dc.identifier.citationThe 2010 Scientific Sessions of the American Heart Association (AHA), Chicago, IL., 13-17 November 2010. In Circulation, 2010, v. 122 n. 21 meeting abstracts, abstract no. 12164en_US
dc.identifier.issn0009-7322-
dc.identifier.urihttp://hdl.handle.net/10722/129885-
dc.descriptionCore 5. Myocardium: Function and Failure - Session Title: Biomarkers in Heart Failure: abstract A12164-
dc.description.abstractBACKGROUND: Abnormal remodelling of myocardial architecture may potentially lead to alteration of ventricular function in patients after repair of tetralogy of Fallot (TOF). Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are candidate biomarkers of myocardial collagen synthesis. OBJECTIVE: We tested the hypothesis that circulating levels of PICP and PIIINP may correlate with ventricular function and synchronicity of ventricular contraction in adolescents after TOF repair. METHODS: Right ventricular (RV) and left ventricular (LV) function and LV mechanical dyssynchrony were assessed by tissue Doppler and 3-dimensional echocardiography in 18 postoperative TOF patients aged 14.5±2.2 years and 11 age-matched controls. Serum PICP and plasma PIIINP levels were determined and correlated with indices of ventricular function and LV systolic dyssynchrony index (SDI). RESULTS: Compared with control, patients had significantly higher circulating PICP (482±194 μg/l vs 313±119 μg/l, p=0.015) and PIIINP (11.4±5.22 μg/l vs 7.6±3.19 μg/l, p=0.04) levels, greater RV end diastolic volume (p=0.013) with increased LV eccentricity (p<0.001), decreased RV ejection fraction (p=0.042), reduced RV IVA (p<0.001), reduced LV IVA (p=0.003), and worse LV SDI (p<0.001). Circulating PICP and PIIINP levels correlated with age (r=-0.44, p=0.016 and r=-0.58, p=0.001, respectively), body mass index (r=-0.43, p=0.019 and r=-0.50, p=0.006, respectively), and LV SDI (r=0.61, p=0.001 and r=0.47, p=0.014, respectively). Additionally, PICP levels correlated negatively with LV IVA (r=-0.42, p=0.025). Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (β=0.46, p=0.021) and PIIINP (β=0.36, p=0.034) after adjustment for age and body mass index. CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in adolescent patients after TOF repair, implicating a possible role of increased collagen synthesis in the pathogenesis of dyssynchronous LV contraction.-
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org-
dc.relation.ispartofCirculation-
dc.subjectCongenital heart disease-
dc.subjectBiomarkers-
dc.subjectCollagen-
dc.subjectEchocardiography-
dc.subjectVentricular remodeling-
dc.titleCirculating levels of biomarkers of collagen synthesis correlate with left ventricular mechanical dyssynchrony in adolescents after repair of tetralogy of falloten_US
dc.typeConference_Paperen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-7322&volume=122&issue=21 suppl.&spage=&epage=&date=2010&atitle=Circulating+levels+of+biomarkers+of+collagen+synthesis+correlate+with+left+ventricular+mechanical+dyssynchrony+in+adolescents+after+repair+of+tetralogy+of+fallot+-
dc.identifier.emailLai, CTM: clarelai@HKUCC-COM.hku.hken_US
dc.identifier.emailChan, KW: kwchan@HKUCC-COM.hku.hken_US
dc.identifier.emailWong, SJ: sjwong@hkucc.hku.hken_US
dc.identifier.emailCheung, YF: xfcheung@hku.hken_US
dc.identifier.hkuros183555en_US
dc.identifier.volume122-
dc.identifier.issue21 meeting abstracts, abstract A12164-
dc.publisher.placeUnited States-
dc.description.otherThe 2010 Scientific Sessions of the American Heart Association, Chicago, MI., 13-17 November 2010. In Circulation, 2010, v. 122 n. 21 Meeting Abstracts, A12164-

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