File Download

There are no files associated with this item.

Conference Paper: MRI of liver fibrosis by fibrin-fibronectin targeted contrast agent

TitleMRI of liver fibrosis by fibrin-fibronectin targeted contrast agent
Authors
Issue Date2010
Citation
The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. How to Cite?
AbstractLiver fibrosis, associated with chronic liver injury, including hepatitis and alcohol intoxication, can progress to cirrhosis and hepatocellular carcinoma. It is characterized by an increased amount of extracellular matrix consisting of fibril-forming collagens and matrix glycoconjugates such as fibronectin The fibrin-fibronectin complexes in fibrotic liver, resulted from cross-linkage between fibrin/fibrinogen and fibronectin, may serve as a specific molecular target for contrast-enhanced MRI. Our preliminary results demonstrated that a fibrin-fibronectin targeted Gd contrast agent provided distinct contrast enhancement in fibrotic liver, as compared with a non-targeted Gd contrast agent, in an experimental model.
DescriptionDiffuse Liver Disease: No. 258
Persistent Identifierhttp://hdl.handle.net/10722/129661

 

DC FieldValueLanguage
dc.contributor.authorGao, DSen_US
dc.contributor.authorTan, Men_US
dc.contributor.authorCheung, JSCen_US
dc.contributor.authorChow, AMKen_US
dc.contributor.authorFan, SJen_US
dc.contributor.authorChan, KWYen_US
dc.contributor.authorMan, Ken_US
dc.contributor.authorLu, ZRen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2010-12-23T08:40:48Z-
dc.date.available2010-12-23T08:40:48Z-
dc.date.issued2010en_US
dc.identifier.citationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010.en_US
dc.identifier.urihttp://hdl.handle.net/10722/129661-
dc.descriptionDiffuse Liver Disease: No. 258-
dc.description.abstractLiver fibrosis, associated with chronic liver injury, including hepatitis and alcohol intoxication, can progress to cirrhosis and hepatocellular carcinoma. It is characterized by an increased amount of extracellular matrix consisting of fibril-forming collagens and matrix glycoconjugates such as fibronectin The fibrin-fibronectin complexes in fibrotic liver, resulted from cross-linkage between fibrin/fibrinogen and fibronectin, may serve as a specific molecular target for contrast-enhanced MRI. Our preliminary results demonstrated that a fibrin-fibronectin targeted Gd contrast agent provided distinct contrast enhancement in fibrotic liver, as compared with a non-targeted Gd contrast agent, in an experimental model.-
dc.languageengen_US
dc.relation.ispartofISMRM-ESMRMB Joint Annual Meeting-
dc.titleMRI of liver fibrosis by fibrin-fibronectin targeted contrast agenten_US
dc.typeConference_Paperen_US
dc.identifier.emailChow, AMK: aprilcmk@hkusua.hku.hken_US
dc.identifier.emailChan, KWY: kannie@graduate.hku.hk-
dc.identifier.emailMan, K: kwanman@hkucc.hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.hkuros178189en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats