File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Sleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis
  • Basic View
  • Metadata View
  • XML View
TitleSleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis
 
AuthorsTang, SCW1 2
Lam, B1
Yao, TJ1
Leung, WS2
Chu, CM2
Ho, YW2
Ip, MSM1
Lai, KN1
 
Keywordscardiovascular morbidity
peritoneal dialysis
sleep apnea
survival
 
Issue Date2010
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
 
CitationKidney International, 2010, v. 77 n. 11, p. 1031-1038 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ki.2010.76
 
AbstractSleep apnea syndrome is increasingly recognized in peritoneal dialysis patients; however, its prognostic implication in this population is unknown. To study this, we prospectively followed the clinical outcome of 93 peritoneal dialysis patients with baseline polysomnography. Of these, 51 were diagnosed with the syndrome defined by an apnea-hypopnea index (AHI) of at least 15 per hour. During a median follow-up of 41 months, there were 30 deaths, of which 17 were due to cardiovascular causes. Kaplan-Meier analysis for the entire follow-up period indicated that patients with sleep apnea at baseline had significantly higher all-cause and cardiovascular mortality during follow-up than those without. Minimal nocturnal saturation and desaturation indices were predictors of mortality and cardiovascular events at univariate analysis. Multivariable Cox regression analysis identified significant sleep apnea syndrome at baseline as an independent predictor of increased all-cause mortality independent of age, male gender, and diabetic status. Further, an absolute increase in the AHI was associated with an incremental risk of cardiovascular events. Thus, sleep apnea syndrome, detected at the start of peritoneal dialysis, is a novel risk predictor for subsequent mortality and cardiovascular events. © 2010 International Society of Nephrology.
 
ISSN0085-2538
2012 Impact Factor: 7.916
2012 SCImago Journal Rankings: 2.697
 
DOIhttp://dx.doi.org/10.1038/ki.2010.76
 
ISI Accession Number IDWOS:000277626700012
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study is supported by the Seed Funding Programme for Basic Research of the University of Hong Kong. We are grateful to Agnes Lai and Barbara Law (Sleep Laboratory), Sandra Luen (Division of Nephrology), Helena Leung and all nursing staff (K18N Dialysis Unit, QMH), WO Lam and all nursing staff (14B Dialysis Unit, UCH) for coordinating the PSG studies, Jack Lam and Jennifer Cheung (Sleep Laboratory) for scoring all PSGs manually, and Suki Ho (Dialysis Unit) for performing all urea kinetics computations. Part of the results from this study were presented in abstract form at the 4th Asian Chapter Meeting of the International Society for Peritoneal Dialysis in Beijing, China, Oct 15-17, 2009.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTang, SCW
 
dc.contributor.authorLam, B
 
dc.contributor.authorYao, TJ
 
dc.contributor.authorLeung, WS
 
dc.contributor.authorChu, CM
 
dc.contributor.authorHo, YW
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorLai, KN
 
dc.date.accessioned2010-12-23T08:38:37Z
 
dc.date.available2010-12-23T08:38:37Z
 
dc.date.issued2010
 
dc.description.abstractSleep apnea syndrome is increasingly recognized in peritoneal dialysis patients; however, its prognostic implication in this population is unknown. To study this, we prospectively followed the clinical outcome of 93 peritoneal dialysis patients with baseline polysomnography. Of these, 51 were diagnosed with the syndrome defined by an apnea-hypopnea index (AHI) of at least 15 per hour. During a median follow-up of 41 months, there were 30 deaths, of which 17 were due to cardiovascular causes. Kaplan-Meier analysis for the entire follow-up period indicated that patients with sleep apnea at baseline had significantly higher all-cause and cardiovascular mortality during follow-up than those without. Minimal nocturnal saturation and desaturation indices were predictors of mortality and cardiovascular events at univariate analysis. Multivariable Cox regression analysis identified significant sleep apnea syndrome at baseline as an independent predictor of increased all-cause mortality independent of age, male gender, and diabetic status. Further, an absolute increase in the AHI was associated with an incremental risk of cardiovascular events. Thus, sleep apnea syndrome, detected at the start of peritoneal dialysis, is a novel risk predictor for subsequent mortality and cardiovascular events. © 2010 International Society of Nephrology.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationKidney International, 2010, v. 77 n. 11, p. 1031-1038 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ki.2010.76
 
dc.identifier.doihttp://dx.doi.org/10.1038/ki.2010.76
 
dc.identifier.epage1038
 
dc.identifier.hkuros176963
 
dc.identifier.isiWOS:000277626700012
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study is supported by the Seed Funding Programme for Basic Research of the University of Hong Kong. We are grateful to Agnes Lai and Barbara Law (Sleep Laboratory), Sandra Luen (Division of Nephrology), Helena Leung and all nursing staff (K18N Dialysis Unit, QMH), WO Lam and all nursing staff (14B Dialysis Unit, UCH) for coordinating the PSG studies, Jack Lam and Jennifer Cheung (Sleep Laboratory) for scoring all PSGs manually, and Suki Ho (Dialysis Unit) for performing all urea kinetics computations. Part of the results from this study were presented in abstract form at the 4th Asian Chapter Meeting of the International Society for Peritoneal Dialysis in Beijing, China, Oct 15-17, 2009.

 
dc.identifier.issn0085-2538
2012 Impact Factor: 7.916
2012 SCImago Journal Rankings: 2.697
 
dc.identifier.issue11
 
dc.identifier.scopuseid_2-s2.0-77955863860
 
dc.identifier.spage1031
 
dc.identifier.urihttp://hdl.handle.net/10722/129536
 
dc.identifier.volume77
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofKidney International
 
dc.relation.referencesReferences in Scopus
 
dc.subjectcardiovascular morbidity
 
dc.subjectperitoneal dialysis
 
dc.subjectsleep apnea
 
dc.subjectsurvival
 
dc.titleSleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Tang, SCW</contributor.author>
<contributor.author>Lam, B</contributor.author>
<contributor.author>Yao, TJ</contributor.author>
<contributor.author>Leung, WS</contributor.author>
<contributor.author>Chu, CM</contributor.author>
<contributor.author>Ho, YW</contributor.author>
<contributor.author>Ip, MSM</contributor.author>
<contributor.author>Lai, KN</contributor.author>
<date.accessioned>2010-12-23T08:38:37Z</date.accessioned>
<date.available>2010-12-23T08:38:37Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>Kidney International, 2010, v. 77 n. 11, p. 1031-1038</identifier.citation>
<identifier.issn>0085-2538</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/129536</identifier.uri>
<description.abstract>Sleep apnea syndrome is increasingly recognized in peritoneal dialysis patients; however, its prognostic implication in this population is unknown. To study this, we prospectively followed the clinical outcome of 93 peritoneal dialysis patients with baseline polysomnography. Of these, 51 were diagnosed with the syndrome defined by an apnea-hypopnea index (AHI) of at least 15 per hour. During a median follow-up of 41 months, there were 30 deaths, of which 17 were due to cardiovascular causes. Kaplan-Meier analysis for the entire follow-up period indicated that patients with sleep apnea at baseline had significantly higher all-cause and cardiovascular mortality during follow-up than those without. Minimal nocturnal saturation and desaturation indices were predictors of mortality and cardiovascular events at univariate analysis. Multivariable Cox regression analysis identified significant sleep apnea syndrome at baseline as an independent predictor of increased all-cause mortality independent of age, male gender, and diabetic status. Further, an absolute increase in the AHI was associated with an incremental risk of cardiovascular events. Thus, sleep apnea syndrome, detected at the start of peritoneal dialysis, is a novel risk predictor for subsequent mortality and cardiovascular events. &#169; 2010 International Society of Nephrology.</description.abstract>
<language>eng</language>
<publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/ki/index.html</publisher>
<relation.ispartof>Kidney International</relation.ispartof>
<subject>cardiovascular morbidity</subject>
<subject>peritoneal dialysis</subject>
<subject>sleep apnea</subject>
<subject>survival</subject>
<title>Sleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1038/ki.2010.76</identifier.doi>
<identifier.scopus>eid_2-s2.0-77955863860</identifier.scopus>
<identifier.hkuros>176963</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-77955863860&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>77</identifier.volume>
<identifier.issue>11</identifier.issue>
<identifier.spage>1031</identifier.spage>
<identifier.epage>1038</identifier.epage>
<identifier.isi>WOS:000277626700012</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. United Christian Hospital Hong Kong