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Article: Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma

TitleRole of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma
Authors
KeywordsBiomarker
Cadherin-17
Oncogene
Therapeutic target
Wnt signaling
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbaroco
Citation
Biochimica Et Biophysica Acta - Reviews On Cancer, 2010, v. 1806 n. 2, p. 138-145 How to Cite?
AbstractCadherin is an important cell adhesion molecule that plays paramount roles in organ development and the maintenance of tissue integrity. Dysregulation of cadherin expression is often associated with disease pathology including tissue dysplasia, tumor formation, and metastasis. Cadherin-17 (CDH17), belonging to a subclass of 7D-cadherin superfamily, is present in fetal liver and gastrointestinal tract during embryogenesis, but the gene becomes silenced in healthy adult liver and stomach tissues. It functions as a peptide transporter and a cell adhesion molecule to maintain tissue integrity in epithelia. However, recent findings from our group and others have reported aberrant expression of CDH17 in major gastrointestinal malignancies including hepatocellular carcinoma (HCC), stomach and colorectal cancers, and its clinical association with tumor metastasis and advanced tumor stages. Furthermore, alternative splice isoforms and genetic polymorphisms of CDH17 gene have been identified in HCC and linked to an increased risk of HCC. CDH17 is an attractive target for HCC therapy. Targeting CDH17 in HCC can inhibit tumor growth and inactivate Wnt signaling pathway in concomitance with activation of tumor suppressor genes. Further investigation on CDH17-mediated oncogenic signaling and cognate molecular mechanisms would shed light on new targeting therapy on HCC and potentially other gastrointestinal malignancies. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/129532
ISSN
2015 Impact Factor: 7.841
2015 SCImago Journal Rankings: 3.852
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong771607M
National Research Foundation2009NRF-POC002-097
University of Hong Kong
Funding Information:

The work was supported by grants from the Research Grants Council of Hong Kong (771607M) and the National Research Foundation Proof-of-Concept Grant Scheme (2009NRF-POC002-097) to J.M.L. and the CRCG Seed Funding Program from The University of Hong Kong (to N.P.L). We would like to acknowledge Mr. Kar-wai Leung for his contribution in the graphical illustration. I.O.N. is Loke Yew Professor in Pathology.

References

 

DC FieldValueLanguage
dc.contributor.authorLee, NPen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorShek, FHen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2010-12-23T08:38:30Z-
dc.date.available2010-12-23T08:38:30Z-
dc.date.issued2010en_HK
dc.identifier.citationBiochimica Et Biophysica Acta - Reviews On Cancer, 2010, v. 1806 n. 2, p. 138-145en_HK
dc.identifier.issn0304-419Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/129532-
dc.description.abstractCadherin is an important cell adhesion molecule that plays paramount roles in organ development and the maintenance of tissue integrity. Dysregulation of cadherin expression is often associated with disease pathology including tissue dysplasia, tumor formation, and metastasis. Cadherin-17 (CDH17), belonging to a subclass of 7D-cadherin superfamily, is present in fetal liver and gastrointestinal tract during embryogenesis, but the gene becomes silenced in healthy adult liver and stomach tissues. It functions as a peptide transporter and a cell adhesion molecule to maintain tissue integrity in epithelia. However, recent findings from our group and others have reported aberrant expression of CDH17 in major gastrointestinal malignancies including hepatocellular carcinoma (HCC), stomach and colorectal cancers, and its clinical association with tumor metastasis and advanced tumor stages. Furthermore, alternative splice isoforms and genetic polymorphisms of CDH17 gene have been identified in HCC and linked to an increased risk of HCC. CDH17 is an attractive target for HCC therapy. Targeting CDH17 in HCC can inhibit tumor growth and inactivate Wnt signaling pathway in concomitance with activation of tumor suppressor genes. Further investigation on CDH17-mediated oncogenic signaling and cognate molecular mechanisms would shed light on new targeting therapy on HCC and potentially other gastrointestinal malignancies. © 2010 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbarocoen_HK
dc.relation.ispartofBiochimica et Biophysica Acta - Reviews on Canceren_HK
dc.subjectBiomarkeren_HK
dc.subjectCadherin-17en_HK
dc.subjectOncogeneen_HK
dc.subjectTherapeutic targeten_HK
dc.subjectWnt signalingen_HK
dc.titleRole of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3002&volume=1806&issue=2&spage=138&epage=145&date=2010&atitle=Role+of+cadherin-17+in+oncogenesis+and+potential+therapeutic+implications+in+hepatocellular+carcinomaen_US
dc.identifier.emailLee, NP: nikkilee@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLee, NP=rp00263en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbcan.2010.05.002en_HK
dc.identifier.pmid20580775-
dc.identifier.scopuseid_2-s2.0-78649462511en_HK
dc.identifier.hkuros176789en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649462511&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1806en_HK
dc.identifier.issue2en_HK
dc.identifier.spage138en_HK
dc.identifier.epage145en_HK
dc.identifier.isiWOS:000285658400002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, NP=7402722690en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridShek, FH=36094922800en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.citeulike7273567-

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