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Article: The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers

TitleThe mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1744-3121
Citation
International Journal Of Immunogenetics, 2010, v. 37 n. 2, p. 111-115 How to Cite?
AbstractGastric cancer is a serious public health cancer and causes nearly 1 million deaths a year worldwide. Th1 cells play critical roles in orchestrating the adaptive immune responses against gastric cancer. T-bet,a member of the T-box family of transcription factors, is the Th1 master regulator and up-regulated during Th1 differentiation. Polymorphisms have also been shown to exist in T-bet. Some reports indicated that some tumours were associated with the drift of Th1 and Th2. In the present work, we investigated the drift of Th1/Th2 by detecting the expression levels of T-bet, IFN-γ IL-4, and GATA-3 in peripheral blood mononuclear cell of gastric cancer patients by realtime PCR, explored the relationship between the polymorphism of T-bet gene and drift of Th1/Th2 by gene sequence, western blot, and gene transfection. Our results indicated that a predominant Th2 pheno- type was existence. T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers. © 2010 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/129531
ISSN
2015 Impact Factor: 1.174
2015 SCImago Journal Rankings: 0.536
ISI Accession Number ID
Funding AgencyGrant Number
Foundation of Social Development Item of Jiangsu ProvinceBS2007041
National Nature Science Foundation of China30710103093
30871193
30972748
Natural Science Foundation of Colleges
Universities in Jiangsu Province and Innovation Fund for candidate of doctor in Jiangsu Province09KJB310001
07KJB320014
CX09B_217Z
Funding Information:

This work was supported by the Foundation of Social Development Item of Jiangsu Province (Grant No. BS2007041), National Nature Science Foundation of China (Grant Nos 30710103093, 30871193, and 30972748), Natural Science Foundation of Colleges, and Universities in Jiangsu Province and Innovation Fund for candidate of doctor in Jiangsu Province (Grant Nos 09KJB310001, 07KJB320014, and CX09B_217Z, respectively).

References

 

DC FieldValueLanguage
dc.contributor.authorYang, Pen_HK
dc.contributor.authorQiu, Gen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorSu, Zen_HK
dc.contributor.authorChen, Jen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorKong, Fen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorEzaki, Ten_HK
dc.contributor.authorXu, Hen_HK
dc.date.accessioned2010-12-23T08:38:29Z-
dc.date.available2010-12-23T08:38:29Z-
dc.date.issued2010en_HK
dc.identifier.citationInternational Journal Of Immunogenetics, 2010, v. 37 n. 2, p. 111-115en_HK
dc.identifier.issn1744-3121en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129531-
dc.description.abstractGastric cancer is a serious public health cancer and causes nearly 1 million deaths a year worldwide. Th1 cells play critical roles in orchestrating the adaptive immune responses against gastric cancer. T-bet,a member of the T-box family of transcription factors, is the Th1 master regulator and up-regulated during Th1 differentiation. Polymorphisms have also been shown to exist in T-bet. Some reports indicated that some tumours were associated with the drift of Th1 and Th2. In the present work, we investigated the drift of Th1/Th2 by detecting the expression levels of T-bet, IFN-γ IL-4, and GATA-3 in peripheral blood mononuclear cell of gastric cancer patients by realtime PCR, explored the relationship between the polymorphism of T-bet gene and drift of Th1/Th2 by gene sequence, western blot, and gene transfection. Our results indicated that a predominant Th2 pheno- type was existence. T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers. © 2010 Blackwell Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1744-3121en_HK
dc.relation.ispartofInternational Journal of Immunogeneticsen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshMutation-
dc.subject.meshStomach Neoplasms - genetics - metabolism-
dc.subject.meshT-Box Domain Proteins - genetics - metabolism-
dc.subject.meshTh1 Cells - metabolism-
dc.subject.meshTh2 Cells - metabolism-
dc.titleThe mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1744-3121&volume=37&issue=2&spage=111&epage=115&date=2010&atitle=The+mutations+of+Th1+cell-specific+T-box+transcription+factor+may+be+associated+with+a+predominant+Th2+phenotype+in+gastric+cancers-
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1744-313X.2010.00899.xen_HK
dc.identifier.pmid20193034en_HK
dc.identifier.scopuseid_2-s2.0-77953576912en_HK
dc.identifier.hkuros176943en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953576912&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue2en_HK
dc.identifier.spage111en_HK
dc.identifier.epage115en_HK
dc.identifier.isiWOS:000275765800008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.citeulike6919236-

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