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- Publisher Website: 10.1111/j.1744-313X.2010.00899.x
- Scopus: eid_2-s2.0-77953576912
- PMID: 20193034
- WOS: WOS:000275765800008
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Article: The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers
Title | The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers | ||||||||||
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Authors | |||||||||||
Issue Date | 2010 | ||||||||||
Publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1744-3121 | ||||||||||
Citation | International Journal Of Immunogenetics, 2010, v. 37 n. 2, p. 111-115 How to Cite? | ||||||||||
Abstract | Gastric cancer is a serious public health cancer and causes nearly 1 million deaths a year worldwide. Th1 cells play critical roles in orchestrating the adaptive immune responses against gastric cancer. T-bet,a member of the T-box family of transcription factors, is the Th1 master regulator and up-regulated during Th1 differentiation. Polymorphisms have also been shown to exist in T-bet. Some reports indicated that some tumours were associated with the drift of Th1 and Th2. In the present work, we investigated the drift of Th1/Th2 by detecting the expression levels of T-bet, IFN-γ IL-4, and GATA-3 in peripheral blood mononuclear cell of gastric cancer patients by realtime PCR, explored the relationship between the polymorphism of T-bet gene and drift of Th1/Th2 by gene sequence, western blot, and gene transfection. Our results indicated that a predominant Th2 pheno- type was existence. T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers. © 2010 Blackwell Publishing Ltd. | ||||||||||
Persistent Identifier | http://hdl.handle.net/10722/129531 | ||||||||||
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.667 | ||||||||||
ISI Accession Number ID |
Funding Information: This work was supported by the Foundation of Social Development Item of Jiangsu Province (Grant No. BS2007041), National Nature Science Foundation of China (Grant Nos 30710103093, 30871193, and 30972748), Natural Science Foundation of Colleges, and Universities in Jiangsu Province and Innovation Fund for candidate of doctor in Jiangsu Province (Grant Nos 09KJB310001, 07KJB320014, and CX09B_217Z, respectively). | ||||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, P | en_HK |
dc.contributor.author | Qiu, G | en_HK |
dc.contributor.author | Wang, S | en_HK |
dc.contributor.author | Su, Z | en_HK |
dc.contributor.author | Chen, J | en_HK |
dc.contributor.author | Wang, S | en_HK |
dc.contributor.author | Kong, F | en_HK |
dc.contributor.author | Lu, L | en_HK |
dc.contributor.author | Ezaki, T | en_HK |
dc.contributor.author | Xu, H | en_HK |
dc.date.accessioned | 2010-12-23T08:38:29Z | - |
dc.date.available | 2010-12-23T08:38:29Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | International Journal Of Immunogenetics, 2010, v. 37 n. 2, p. 111-115 | en_HK |
dc.identifier.issn | 1744-3121 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/129531 | - |
dc.description.abstract | Gastric cancer is a serious public health cancer and causes nearly 1 million deaths a year worldwide. Th1 cells play critical roles in orchestrating the adaptive immune responses against gastric cancer. T-bet,a member of the T-box family of transcription factors, is the Th1 master regulator and up-regulated during Th1 differentiation. Polymorphisms have also been shown to exist in T-bet. Some reports indicated that some tumours were associated with the drift of Th1 and Th2. In the present work, we investigated the drift of Th1/Th2 by detecting the expression levels of T-bet, IFN-γ IL-4, and GATA-3 in peripheral blood mononuclear cell of gastric cancer patients by realtime PCR, explored the relationship between the polymorphism of T-bet gene and drift of Th1/Th2 by gene sequence, western blot, and gene transfection. Our results indicated that a predominant Th2 pheno- type was existence. T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers. © 2010 Blackwell Publishing Ltd. | en_HK |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1744-3121 | en_HK |
dc.relation.ispartof | International Journal of Immunogenetics | en_HK |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.subject.mesh | Mutation | - |
dc.subject.mesh | Stomach Neoplasms - genetics - metabolism | - |
dc.subject.mesh | T-Box Domain Proteins - genetics - metabolism | - |
dc.subject.mesh | Th1 Cells - metabolism | - |
dc.subject.mesh | Th2 Cells - metabolism | - |
dc.title | The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1744-3121&volume=37&issue=2&spage=111&epage=115&date=2010&atitle=The+mutations+of+Th1+cell-specific+T-box+transcription+factor+may+be+associated+with+a+predominant+Th2+phenotype+in+gastric+cancers | - |
dc.identifier.email | Lu, L:liweilu@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lu, L=rp00477 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1744-313X.2010.00899.x | en_HK |
dc.identifier.pmid | 20193034 | en_HK |
dc.identifier.scopus | eid_2-s2.0-77953576912 | en_HK |
dc.identifier.hkuros | 176943 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77953576912&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 37 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 111 | en_HK |
dc.identifier.epage | 115 | en_HK |
dc.identifier.isi | WOS:000275765800008 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.citeulike | 6919236 | - |
dc.identifier.issnl | 1744-3121 | - |