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Article: Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE

TitleMesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE
Authors
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nrrheum/index.html
Citation
Nature Reviews Rheumatology, 2010, v. 6 n. 8, p. 486-489 How to Cite?
AbstractBackground. A 19-year-old girl was diagnosed with systemic lupus erythematosus, based on findings of arthritis, malar rash, positive antinuclear antibody test and high levels of antibodies to double-stranded DNA. Two months after diagnosis, the patient presented with a sudden drop in blood hemoglobin level. Several days later, she developed bloody sputum, rapidly progressive dyspnea and hypoxemia. High-resolution CT showed diffuse alveolar infiltrates in both lung fields.Investigations. Physical examination, complete blood count, erythrocyte sedimentation rate, urinalysis, 24-h urine protein excretion, fecal occult blood test, d-dimer test, acid hemolysis test, activated partial thromboplastin time and prothrombin time, direct and indirect Coombs tests, bone marrow smear, arterial blood gas, sputum smear and culture, and high-resolution CT scan of the chest.Diagnosis. Diffuse alveolar hemorrhage associated with systemic lupus erythematosus.Management. The patient did not respond to pulsed intravenous methylprednisolone (two courses of 500 mg per day for 3 days) and intravenous immunoglobulin (20 g per day for 5 days). The patient was referred to a specialist treatment center for allogenic transplantation using umbilical-cord-derived mesenchymal stem cells. She underwent transplantation with an infusion of 8 - 10 7 mesenchymal stem cells. After showing dramatic improvements in her clinical condition, oxygenation level, radiographic and hematological status, the patient was discharged from hospital approximately 5 weeks after undergoing transplantation. © 2010 Macmillan Publishers Limited.
Persistent Identifierhttp://hdl.handle.net/10722/129525
ISSN
2015 Impact Factor: 10.531
2015 SCImago Journal Rankings: 2.728
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30772014
30972736
Jiangsu Province 135 Talent FoundationRC2007002
Jiangsu Province Natural Science Foundation09KJB320010
Jiangsu Province Science-Technology Achievement Transforming FoundationBA2009124
Jiangsu Province "Six Summit Talent" Foundation
Nanjing Health Bureau Young Scientists Launching ProjectQyK09174
Funding Information:

The authors are grateful to the patient's family for granting permission to write this case report. They thank Dr Xiang Hu and Shengqin ye (Jiangsu Stem Cell Bank, Jiangsu, China) for providing the MSCs. They thank Dr Gary S. Gilkeson (Department of Rheumatology, Medical University of South Carolina, Charleston, SC, USA) for his critical review of the manuscript. This work was supported by grants from the National Natural Science Foundation of China (No. 30772014 and No. 30972736), Jiangsu Province 135 Talent Foundation (RC2007002), Jiangsu Province Natural Science Foundation (No. 09KJB320010), Jiangsu Province Science-Technology Achievement Transforming Foundation (BA2009124), Jiangsu Province "Six Summit Talent" Foundation and Nanjing Health Bureau Young Scientists Launching Project (QyK09174).

References

 

DC FieldValueLanguage
dc.contributor.authorLiang, Jen_HK
dc.contributor.authorGu, Fen_HK
dc.contributor.authorWang, Hen_HK
dc.contributor.authorHua, Ben_HK
dc.contributor.authorHou, Yen_HK
dc.contributor.authorShi, Sen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorSun, Len_HK
dc.date.accessioned2010-12-23T08:38:26Z-
dc.date.available2010-12-23T08:38:26Z-
dc.date.issued2010en_HK
dc.identifier.citationNature Reviews Rheumatology, 2010, v. 6 n. 8, p. 486-489en_HK
dc.identifier.issn1759-4790en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129525-
dc.description.abstractBackground. A 19-year-old girl was diagnosed with systemic lupus erythematosus, based on findings of arthritis, malar rash, positive antinuclear antibody test and high levels of antibodies to double-stranded DNA. Two months after diagnosis, the patient presented with a sudden drop in blood hemoglobin level. Several days later, she developed bloody sputum, rapidly progressive dyspnea and hypoxemia. High-resolution CT showed diffuse alveolar infiltrates in both lung fields.Investigations. Physical examination, complete blood count, erythrocyte sedimentation rate, urinalysis, 24-h urine protein excretion, fecal occult blood test, d-dimer test, acid hemolysis test, activated partial thromboplastin time and prothrombin time, direct and indirect Coombs tests, bone marrow smear, arterial blood gas, sputum smear and culture, and high-resolution CT scan of the chest.Diagnosis. Diffuse alveolar hemorrhage associated with systemic lupus erythematosus.Management. The patient did not respond to pulsed intravenous methylprednisolone (two courses of 500 mg per day for 3 days) and intravenous immunoglobulin (20 g per day for 5 days). The patient was referred to a specialist treatment center for allogenic transplantation using umbilical-cord-derived mesenchymal stem cells. She underwent transplantation with an infusion of 8 - 10 7 mesenchymal stem cells. After showing dramatic improvements in her clinical condition, oxygenation level, radiographic and hematological status, the patient was discharged from hospital approximately 5 weeks after undergoing transplantation. © 2010 Macmillan Publishers Limited.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nrrheum/index.htmlen_HK
dc.relation.ispartofNature Reviews Rheumatologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshFemale-
dc.subject.meshHemoptysis - etiology - therapy-
dc.subject.meshHumans-
dc.subject.meshLupus Erythematosus, Systemic - complications - therapy-
dc.subject.meshMesenchymal Stem Cell Transplantation-
dc.titleMesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLEen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1759-4790&volume=6&issue=8&spage=486&epage=489&date=2010&atitle=Mesenchymal+stem+cell+transplantation+for+diffuse+alveolar+hemorrhage+in+SLE-
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1038/nrrheum.2010.80en_HK
dc.identifier.pmid20517294-
dc.identifier.scopuseid_2-s2.0-77955320722en_HK
dc.identifier.hkuros176944en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955320722&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue8en_HK
dc.identifier.spage486en_HK
dc.identifier.epage489en_HK
dc.identifier.isiWOS:000280561500009-
dc.publisher.placeUnited Kingdomen_HK

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