Article: P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytologypotential biomarkers for diagnosis and progress prediction of cervical neoplasia
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- Publisher Website: 10.1038/modpathol.2009.198
- Scopus: eid_2-s2.0-77950518293
- PMID: 20081800
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| Title | P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytologypotential biomarkers for diagnosis and progress prediction of cervical neoplasia |
|---|---|
| Authors | Cheung, ANY1 Tsun, KL1 Ng, KM1 Szeto, E1 Siu, MK1 Wong, ES1 Ngan, HY1 |
| Keywords | Liquid-based cervical cytology P63 P73 |
| Issue Date | 2010 |
| Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/ |
| Citation | Modern Pathology, 2010, v. 23 n. 4, p. 559-566 [How to Cite?] DOI: http://dx.doi.org/10.1038/modpathol.2009.198 |
| Abstract | P63 and p73 are two homologues of the important tumor suppressor gene p53. In this study, we investigated p63 and p73 expression by immunocytochemistry using antibodies for TAp73 and p634A4 isoforms in 91 high-grade and 107 low-grade squamous intraepithelial lesions, 212 atypical squamous cells of undetermined significance, 9 squamous cell carcinomas and 63 normal samples from an Asian screening population together with 47 hospital samples of carcinomas. There was significant correlation between the TAp73 and p634A4 indices (P0.0001). Significantly, higher TAp73 and p634A4 indices were found in high-grade lesions or carcinoma when compared with atypical squamous cells and low-grade lesions (P0.0001). Among atypical squamous cells, p634A4 indices of cases that subsequently progressed to low-grade (P0.031) or high-grade lesions (P0.006) were significantly higher than those that did not. For atypical squamous cells positive for high-risk human papillomavirus (HPV) as detected by Digene (61%), cases with high p634A4 index were still more likely to have subsequent high-grade lesions detected (P0.016). Among low-grade lesions, significantly higher TAp73 (P0.038) was found in cases that subsequently progressed to high-grade lesions. There was significant correlation between presence of high-risk HPV and p634A4 index (P0.01). In summary, p63 and p73 immunocytochemistry are potential good markers for detection of carcinoma and high-grade lesions in cervical cytology samples and for triage management of women with atypical squamous cells and low-grade lesions. © 2010 USCAP, Inc. All rights reserved. |
| ISSN | 0893-3952 2011 Impact Factor: 4.792 2011 SCImago Journal Rankings: 0.565 |
| DOI | http://dx.doi.org/10.1038/modpathol.2009.198 |
| References | References in Scopus |
| Grants | Cervical cancer screening by enhanced cervical cytology-application of novel markers |
| dc.contributor.author | Cheung, ANY | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Tsun, KL | ||||||
| dc.contributor.author | Ng, KM | ||||||
| dc.contributor.author | Szeto, E | ||||||
| dc.contributor.author | Siu, MK | ||||||
| dc.contributor.author | Wong, ES | ||||||
| dc.contributor.author | Ngan, HY | ||||||
| dc.date.accessioned | 2010-12-23T08:38:26Z | ||||||
| dc.date.available | 2010-12-23T08:38:26Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | P63 and p73 are two homologues of the important tumor suppressor gene p53. In this study, we investigated p63 and p73 expression by immunocytochemistry using antibodies for TAp73 and p634A4 isoforms in 91 high-grade and 107 low-grade squamous intraepithelial lesions, 212 atypical squamous cells of undetermined significance, 9 squamous cell carcinomas and 63 normal samples from an Asian screening population together with 47 hospital samples of carcinomas. There was significant correlation between the TAp73 and p634A4 indices (P0.0001). Significantly, higher TAp73 and p634A4 indices were found in high-grade lesions or carcinoma when compared with atypical squamous cells and low-grade lesions (P0.0001). Among atypical squamous cells, p634A4 indices of cases that subsequently progressed to low-grade (P0.031) or high-grade lesions (P0.006) were significantly higher than those that did not. For atypical squamous cells positive for high-risk human papillomavirus (HPV) as detected by Digene (61%), cases with high p634A4 index were still more likely to have subsequent high-grade lesions detected (P0.016). Among low-grade lesions, significantly higher TAp73 (P0.038) was found in cases that subsequently progressed to high-grade lesions. There was significant correlation between presence of high-risk HPV and p634A4 index (P0.01). In summary, p63 and p73 immunocytochemistry are potential good markers for detection of carcinoma and high-grade lesions in cervical cytology samples and for triage management of women with atypical squamous cells and low-grade lesions. © 2010 USCAP, Inc. All rights reserved. | ||||||
| dc.description.grant | Cervical cancer screening by enhanced cervical cytology-application of novel markers | ||||||
| dc.description.grantcode | 96206 | ||||||
| dc.description.nature | link_to_OA_fulltext | ||||||
| dc.identifier.citation | Modern Pathology, 2010, v. 23 n. 4, p. 559-566 [How to Cite?] DOI: http://dx.doi.org/10.1038/modpathol.2009.198 | ||||||
| dc.identifier.citeulike | 6553954 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/modpathol.2009.198 | ||||||
| dc.identifier.epage | 566 | ||||||
| dc.identifier.hkuros | 176804 | ||||||
| dc.identifier.isi | WOS:000276197100008
Funding Information: This study was supported by the Research Fund for the Control of Infectious Diseases/Health and Health Services Fund (Project Number: 06060642). The high-risk HPV Hybrid Capture Test II was supported by the SK Yee Medical Foundation. | ||||||
| dc.identifier.issn | 0893-3952 2011 Impact Factor: 4.792 2011 SCImago Journal Rankings: 0.565 | ||||||
| dc.identifier.issue | 4 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 20081800 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77950518293 | ||||||
| dc.identifier.spage | 559 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/129524 | ||||||
| dc.identifier.volume | 23 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/ | ||||||
| dc.publisher.place | United Kingdom | ||||||
| dc.relation.ispartof | Modern Pathology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Carcinoma, Squamous Cell - diagnosis - genetics | ||||||
| dc.subject.mesh | DNA-Binding Proteins - biosynthesis - genetics | ||||||
| dc.subject.mesh | Membrane Proteins - biosynthesis - genetics | ||||||
| dc.subject.mesh | Nuclear Proteins - biosynthesis - genetics | ||||||
| dc.subject.mesh | Precancerous Conditions - diagnosis - genetics | ||||||
| dc.subject | Liquid-based cervical cytology | ||||||
| dc.subject | P63 | ||||||
| dc.subject | P73 | ||||||
| dc.title | P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytologypotential biomarkers for diagnosis and progress prediction of cervical neoplasia | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong