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Article: Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow

TitleLeptin signaling protects NK cells from apoptosis during development in mouse bone marrow
Authors
KeywordsBone marrow
Lymphocyte development
NK cell
Issue Date2009
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Chinese Journal Of Cellular And Molecular Immunology, 2009, v. 6 n. 5, p. 353-360 How to Cite?
Abstract
Increasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. ©2009 Chinese Society of Immunology and University of Science & Technology of China.
DescriptionFree fulltext link - http://www.cmi.ustc.edu.cn/6/5/353.pdf
Persistent Identifierhttp://hdl.handle.net/10722/129513
ISSN
2013 SCImago Journal Rankings: 0.131
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, CKCen_HK
dc.contributor.authorLam, QLKen_HK
dc.contributor.authorYang, Men_HK
dc.contributor.authorKo, KHen_HK
dc.contributor.authorSun, Len_HK
dc.contributor.authorMa, Ren_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWu, CYen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorLu, Len_HK
dc.date.accessioned2010-12-23T08:38:19Z-
dc.date.available2010-12-23T08:38:19Z-
dc.date.issued2009en_HK
dc.identifier.citationChinese Journal Of Cellular And Molecular Immunology, 2009, v. 6 n. 5, p. 353-360en_HK
dc.identifier.issn1007-8738en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129513-
dc.descriptionFree fulltext link - http://www.cmi.ustc.edu.cn/6/5/353.pdf-
dc.description.abstractIncreasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. ©2009 Chinese Society of Immunology and University of Science & Technology of China.en_HK
dc.languageengen_US
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html-
dc.relation.ispartofChinese Journal of Cellular and Molecular Immunologyen_HK
dc.subjectBone marrowen_HK
dc.subjectLymphocyte developmenten_HK
dc.subjectNK cellen_HK
dc.titleLeptin signaling protects NK cells from apoptosis during development in mouse bone marrowen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1672-7681&volume=6&issue=5&spage=353&epage=360&date=2009&atitle=Leptin+signaling+protects+NK+cells+from+apoptosis+during+development+in+mouse+bone+marrowen_US
dc.identifier.emailLam, QLK: qlam@pathology.hku.hken_HK
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hken_HK
dc.identifier.emailLu, L: liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLam, QLK=rp00312en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/cmi.2009.46-
dc.identifier.pmid19887048-
dc.identifier.scopuseid_2-s2.0-70350776515en_HK
dc.identifier.hkuros176933en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350776515&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spage353en_HK
dc.identifier.epage360en_HK
dc.identifier.isiWOS:000274324100005-
dc.identifier.scopusauthoridLo, CKC=24825171000en_HK
dc.identifier.scopusauthoridLam, QLK=8722491000en_HK
dc.identifier.scopusauthoridYang, M=8984637400en_HK
dc.identifier.scopusauthoridKo, KH=7202688627en_HK
dc.identifier.scopusauthoridSun, L=35265069800en_HK
dc.identifier.scopusauthoridMa, R=55165746200en_HK
dc.identifier.scopusauthoridWang, S=23500575700en_HK
dc.identifier.scopusauthoridXu, H=7407449104en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWu, CY=7501660961en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK

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