Article: Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow

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TitleLeptin signaling protects NK cells from apoptosis during development in mouse bone marrow
AuthorsLo, CKC3
Lam, QLK3
Yang, M3
Ko, KH3
Sun, L2
Ma, R1
Wang, S1
Xu, H1
Tam, S5
Wu, CY4
Zheng, BJ3
Lu, L3
KeywordsBone marrow
Lymphocyte development
NK cell
Issue Date2009
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
CitationChinese Journal Of Cellular And Molecular Immunology, 2009, v. 6 n. 5, p. 353-360 [How to Cite?]
DOI: http://dx.doi.org/10.1038/cmi.2009.46
AbstractIncreasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. ©2009 Chinese Society of Immunology and University of Science & Technology of China.
DescriptionFree fulltext link - http://www.cmi.ustc.edu.cn/6/5/353.pdf
ISSN1007-8738
2011 SCImago Journal Rankings: 0.032
DOIhttp://dx.doi.org/10.1038/cmi.2009.46
ISI Accession Number IDWOS:000274324100005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLo, CKC
dc.contributor.authorLam, QLK
dc.contributor.authorYang, M
dc.contributor.authorKo, KH
dc.contributor.authorSun, L
dc.contributor.authorMa, R
dc.contributor.authorWang, S
dc.contributor.authorXu, H
dc.contributor.authorTam, S
dc.contributor.authorWu, CY
dc.contributor.authorZheng, BJ
dc.contributor.authorLu, L
dc.date.accessioned2010-12-23T08:38:19Z
dc.date.available2010-12-23T08:38:19Z
dc.date.issued2009
dc.description.abstractIncreasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. ©2009 Chinese Society of Immunology and University of Science & Technology of China.
dc.description.natureLink_to_subscribed_fulltext
dc.descriptionFree fulltext link - http://www.cmi.ustc.edu.cn/6/5/353.pdf
dc.identifier.citationChinese Journal Of Cellular And Molecular Immunology, 2009, v. 6 n. 5, p. 353-360 [How to Cite?]
DOI: http://dx.doi.org/10.1038/cmi.2009.46
dc.identifier.doihttp://dx.doi.org/10.1038/cmi.2009.46
dc.identifier.epage360
dc.identifier.hkuros176933
dc.identifier.isiWOS:000274324100005
dc.identifier.issn1007-8738
2011 SCImago Journal Rankings: 0.032
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid19887048
dc.identifier.scopuseid_2-s2.0-70350776515
dc.identifier.spage353
dc.identifier.urihttp://hdl.handle.net/10722/129513
dc.identifier.volume6
dc.languageeng
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
dc.relation.ispartofChinese Journal of Cellular and Molecular Immunology
dc.relation.referencesReferences in Scopus
dc.subjectBone marrow
dc.subjectLymphocyte development
dc.subjectNK cell
dc.titleLeptin signaling protects NK cells from apoptosis during development in mouse bone marrow
dc.typeArticle
Author Affiliations
  1. Jiangsu University
  2. Nanjing University, School of Medicine
  3. The University of Hong Kong
  4. Sun Yat-Sen University
  5. Queen Mary Hospital Hong Kong