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Article: Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow
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TitleLeptin signaling protects NK cells from apoptosis during development in mouse bone marrow
 
AuthorsLo, CKC3
Lam, QLK3
Yang, M3
Ko, KH3
Sun, L2
Ma, R1
Wang, S1
Xu, H1
Tam, S5
Wu, CY4
Zheng, BJ3
Lu, L3
 
KeywordsBone marrow
Lymphocyte development
NK cell
 
Issue Date2009
 
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
 
CitationChinese Journal Of Cellular And Molecular Immunology, 2009, v. 6 n. 5, p. 353-360 [How to Cite?]
DOI: http://dx.doi.org/10.1038/cmi.2009.46
 
AbstractIncreasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. ©2009 Chinese Society of Immunology and University of Science & Technology of China.
 
DescriptionFree fulltext link - http://www.cmi.ustc.edu.cn/6/5/353.pdf
 
ISSN1007-8738
2013 SCImago Journal Rankings: 0.131
 
DOIhttp://dx.doi.org/10.1038/cmi.2009.46
 
ISI Accession Number IDWOS:000274324100005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLo, CKC
 
dc.contributor.authorLam, QLK
 
dc.contributor.authorYang, M
 
dc.contributor.authorKo, KH
 
dc.contributor.authorSun, L
 
dc.contributor.authorMa, R
 
dc.contributor.authorWang, S
 
dc.contributor.authorXu, H
 
dc.contributor.authorTam, S
 
dc.contributor.authorWu, CY
 
dc.contributor.authorZheng, BJ
 
dc.contributor.authorLu, L
 
dc.date.accessioned2010-12-23T08:38:19Z
 
dc.date.available2010-12-23T08:38:19Z
 
dc.date.issued2009
 
dc.description.abstractIncreasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. ©2009 Chinese Society of Immunology and University of Science & Technology of China.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.descriptionFree fulltext link - http://www.cmi.ustc.edu.cn/6/5/353.pdf
 
dc.identifier.citationChinese Journal Of Cellular And Molecular Immunology, 2009, v. 6 n. 5, p. 353-360 [How to Cite?]
DOI: http://dx.doi.org/10.1038/cmi.2009.46
 
dc.identifier.doihttp://dx.doi.org/10.1038/cmi.2009.46
 
dc.identifier.epage360
 
dc.identifier.hkuros176933
 
dc.identifier.isiWOS:000274324100005
 
dc.identifier.issn1007-8738
2013 SCImago Journal Rankings: 0.131
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid19887048
 
dc.identifier.scopuseid_2-s2.0-70350776515
 
dc.identifier.spage353
 
dc.identifier.urihttp://hdl.handle.net/10722/129513
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
 
dc.relation.ispartofChinese Journal of Cellular and Molecular Immunology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBone marrow
 
dc.subjectLymphocyte development
 
dc.subjectNK cell
 
dc.titleLeptin signaling protects NK cells from apoptosis during development in mouse bone marrow
 
dc.typeArticle
 
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<contributor.author>Tam, S</contributor.author>
<contributor.author>Wu, CY</contributor.author>
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<description.abstract>Increasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice. Flow cytometric analysis of db/db BM cells revealed significantly decreased frequencies of developing NK cells at various stages of differentiation. BM db/db NK cells displayed markedly increased apoptosis but maintained normal cell cycling status and proliferative capacity. Moreover, recombinant leptin could significantly enhance the survival of NK cells from wild-type mice in cultures. Further examination on NK cell functional activity showed that db/db NK cells exhibited normal intrinsic cytotoxicity with significantly increased IL-10 production. Taken together, our findings suggest that leptin signaling regulates NK cell development via enhancing the survival of immature NK cells in mouse BM. &#169;2009 Chinese Society of Immunology and University of Science &amp; Technology of China.</description.abstract>
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Author Affiliations
  1. Jiangsu University
  2. Nanjing University, School of Medicine
  3. The University of Hong Kong
  4. Sun Yat-Sen University
  5. Queen Mary Hospital Hong Kong