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Article: Cutting edge: Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells

TitleCutting edge: Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells
Authors
Issue Date2010
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2010, v. 184 n. 7, p. 3321-3325 How to Cite?
AbstractAlthough B cells have been shown to possess a regulatory function, microenvironmental factors or cytokines involved in the induction of regulatory B cells remain largely uncharacterized. B cell-activating factor (BAFF), a member of TNF family cytokines, is a key regulator for Bcell maturation and function. In this study, we detected significantly increased numbers of IL-10-producing B cells in BAFF-treated B cell cultures, an effect specifically abrogated by neutralization of BAFF with TACIFc. BAFF-induced IL-10-producing B cells showed a distinct CD1d hiCD5 + phenotype, which were mainly derived from marginal zone B cells. Moreover, BAFF activated transcription factor AP-1 for binding to IL-10 promoter. Notably, BAFF treatment in vivo increased the number of IL-10-producing B cells in marginal zone regions. Furthermore, BAFF-induced IL-10-producing B cells possess a regulatory function both in vitro and in vivo. Taken together, our findings identify a novel function of BAFF in the induction of IL-10-producing regulatory B cells. Copyright © 2010 by The American Association of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/129500
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong
National Natural Science Foundation of China
Hong Kong Research Grants Council Joint Research Scheme
Funding Information:

This work was supported by grams to L.L. from the Research Grants Council of Hong Kong and the National Natural Science Foundation of China and Hong Kong Research Grants Council Joint Research Scheme.

References

 

DC FieldValueLanguage
dc.contributor.authorYang, Men_HK
dc.contributor.authorSun, Len_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorKo, KHen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorCao, Xen_HK
dc.contributor.authorLu, Len_HK
dc.date.accessioned2010-12-23T08:38:10Z-
dc.date.available2010-12-23T08:38:10Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Immunology, 2010, v. 184 n. 7, p. 3321-3325en_HK
dc.identifier.issn0022-1767en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129500-
dc.description.abstractAlthough B cells have been shown to possess a regulatory function, microenvironmental factors or cytokines involved in the induction of regulatory B cells remain largely uncharacterized. B cell-activating factor (BAFF), a member of TNF family cytokines, is a key regulator for Bcell maturation and function. In this study, we detected significantly increased numbers of IL-10-producing B cells in BAFF-treated B cell cultures, an effect specifically abrogated by neutralization of BAFF with TACIFc. BAFF-induced IL-10-producing B cells showed a distinct CD1d hiCD5 + phenotype, which were mainly derived from marginal zone B cells. Moreover, BAFF activated transcription factor AP-1 for binding to IL-10 promoter. Notably, BAFF treatment in vivo increased the number of IL-10-producing B cells in marginal zone regions. Furthermore, BAFF-induced IL-10-producing B cells possess a regulatory function both in vitro and in vivo. Taken together, our findings identify a novel function of BAFF in the induction of IL-10-producing regulatory B cells. Copyright © 2010 by The American Association of Immunologists, Inc.en_HK
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_HK
dc.relation.ispartofJournal of Immunologyen_HK
dc.rightsThis is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (The AAI), publisher of The JI, holds the copyright to this manuscript. This manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). The AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org-
dc.subject.meshAnimals-
dc.subject.meshB-Cell Activating Factor - immunology - metabolism-
dc.subject.meshB-Lymphocyte Subsets - immunology - metabolism-
dc.subject.meshB-Lymphocytes - immunology - metabolism-
dc.subject.meshCell Differentiation - immunology-
dc.titleCutting edge: Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1767&volume=184&issue=7&spage=3321&epage=3325&date=2010&atitle=Cutting+Edge:+Novel+Function+of+B+Cell-Activating+Factor+in+the+Induction+of+IL-10–Producing+Regulatory+B+Cells-
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.4049/jimmunol.0902551en_HK
dc.identifier.pmid20208006en_HK
dc.identifier.scopuseid_2-s2.0-77951640991en_HK
dc.identifier.hkuros176941en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951640991&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume184en_HK
dc.identifier.issue7en_HK
dc.identifier.spage3321en_HK
dc.identifier.epage3325en_HK
dc.identifier.eissn1550-6606-
dc.identifier.isiWOS:000275927600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10002921956-
dc.identifier.scopusauthoridYang, M=35228247800en_HK
dc.identifier.scopusauthoridSun, L=35265069800en_HK
dc.identifier.scopusauthoridWang, S=23500575700en_HK
dc.identifier.scopusauthoridKo, KH=7202688627en_HK
dc.identifier.scopusauthoridXu, H=7407449104en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridCao, X=7403370836en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK
dc.identifier.citeulike10795443-

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