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Article: Immunogenetics in SARS: a case-control study.

TitleImmunogenetics in SARS: a case-control study.
Authors
Issue Date2010
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2010, v. 16 n. 5 Suppl 4, p. 29-33 How to Cite?
AbstractKey Messages: 1. Human leukocyte antigen (HLA) genotypes from 102 SARS patients (susceptible) and 108 SARS contacts (resistant) were obtained. 2. Allelic frequencies of the Class I (HLA-A, -B, and -Cw) and Class II (HLA-DR and -DQ) genes from these genetically unrelated subjects were compared. 3. A significantly higher frequency of DRB4*01010101 was found in the SARS-susceptible than SARS-resistant group. In contrast, significantly higher frequencies of HLA-B*1502 and HLADRB3*030101 were found in the SARS-resistant than SARSsusceptible group. However, none of these associations was significant after Bonferroni correction. Further, analysis of 10/36 genetically related families did not reveal any HLA alleles associated with SARS susceptibility or resistance. 4. We could not confirm previous findings of an HLA association with susceptibility or resistance to SARS. The significance of these associations needs to be validated by further independent studies.
Persistent Identifierhttp://hdl.handle.net/10722/129473
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorNg, MHen_HK
dc.contributor.authorCheng, SHen_HK
dc.contributor.authorLau, KMen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorZee, BCen_HK
dc.contributor.authorSung, JJen_HK
dc.date.accessioned2010-12-23T08:37:46Z-
dc.date.available2010-12-23T08:37:46Z-
dc.date.issued2010en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2010, v. 16 n. 5 Suppl 4, p. 29-33en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129473-
dc.description.abstractKey Messages: 1. Human leukocyte antigen (HLA) genotypes from 102 SARS patients (susceptible) and 108 SARS contacts (resistant) were obtained. 2. Allelic frequencies of the Class I (HLA-A, -B, and -Cw) and Class II (HLA-DR and -DQ) genes from these genetically unrelated subjects were compared. 3. A significantly higher frequency of DRB4*01010101 was found in the SARS-susceptible than SARS-resistant group. In contrast, significantly higher frequencies of HLA-B*1502 and HLADRB3*030101 were found in the SARS-resistant than SARSsusceptible group. However, none of these associations was significant after Bonferroni correction. Further, analysis of 10/36 genetically related families did not reveal any HLA alleles associated with SARS susceptibility or resistance. 4. We could not confirm previous findings of an HLA association with susceptibility or resistance to SARS. The significance of these associations needs to be validated by further independent studies.-
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.-
dc.subject.meshCase-Control Studies-
dc.subject.meshHLA Antigens - genetics-
dc.subject.meshImmunogenetic Phenomena-
dc.subject.meshSARS Virus - pathogenicity-
dc.subject.meshSevere Acute Respiratory Syndrome - epidemiology - genetics - immunology-
dc.titleImmunogenetics in SARS: a case-control study.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=16&issue=5, suppl. 4&spage=29&epage=33&date=2010&atitle=Immunogenetics+in+SARS:+a+case-control+study-
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.pmid20864745-
dc.identifier.scopuseid_2-s2.0-79952116458en_HK
dc.identifier.hkuros183440en_US
dc.identifier.volume16en_HK
dc.identifier.issue5 Suppl 4en_HK
dc.identifier.spage29en_HK
dc.identifier.epage33en_HK
dc.publisher.placeHong Kongen_HK

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