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Article: Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia

TitlePositive symptoms and white matter microstructure in never-medicated first episode schizophrenia
Authors
KeywordsDiffusion tensor imaging
drug-naive
fractional anisotropy
PANSS
psychosis
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2011, v. 41 n. 8, p. 1709-1719 How to Cite?
AbstractBackground We investigated cerebral structural connectivity and its relationship to symptoms in never-medicated individuals with first-onset schizophrenia using diffusion tensor imaging (DTI).Method We recruited subjects with first episode DSM-IV schizophrenia who had never been exposed to antipsychotic medication (n=34) and age-matched healthy volunteers (n=32). All subjects received DTI and structural magnetic resonance imaging scans. Patients' symptoms were assessed on the Positive and Negative Syndrome Scale. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values significantly correlated with symptom scores.Results In patients with first-episode schizophrenia, positive symptoms correlated positively with FA scores in white matter associated with the right frontal lobe, left anterior cingulate gyrus, left superior temporal gyrus, right middle temporal gyrus, right middle cingulate gyrus, and left cuneus. Importantly, FA in each of these regions was lower in patients than controls, but patients with more positive symptoms had FA values closer to controls. We found no significant correlations between FA and negative symptoms.Conclusions The newly-diagnosed, neuroleptic-naive patients had lower FA scores in the brain compared with controls. There was positive correlation between FA scores and positive symptoms scores in frontotemporal tracts, including left fronto-occipital fasciculus and left inferior longitudinal fasciculus. This implies that white matter dysintegrity is already present in the pre-treatment phase and that FA is likely to decrease after clinical treatment or symptom remission. © 2011 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/129356
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
Funding AgencyGrant Number
CRCG, The University of Hong Kong
Funding Information:

This work was supported by a research grant to Dr S. E. Chua and Dr E. Y. H. Chen from the CRCG, The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorChan, KKSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorDeng, MYen_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorChen, Een_HK
dc.date.accessioned2010-12-23T08:35:54Z-
dc.date.available2010-12-23T08:35:54Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 8, p. 1709-1719en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129356-
dc.description.abstractBackground We investigated cerebral structural connectivity and its relationship to symptoms in never-medicated individuals with first-onset schizophrenia using diffusion tensor imaging (DTI).Method We recruited subjects with first episode DSM-IV schizophrenia who had never been exposed to antipsychotic medication (n=34) and age-matched healthy volunteers (n=32). All subjects received DTI and structural magnetic resonance imaging scans. Patients' symptoms were assessed on the Positive and Negative Syndrome Scale. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values significantly correlated with symptom scores.Results In patients with first-episode schizophrenia, positive symptoms correlated positively with FA scores in white matter associated with the right frontal lobe, left anterior cingulate gyrus, left superior temporal gyrus, right middle temporal gyrus, right middle cingulate gyrus, and left cuneus. Importantly, FA in each of these regions was lower in patients than controls, but patients with more positive symptoms had FA values closer to controls. We found no significant correlations between FA and negative symptoms.Conclusions The newly-diagnosed, neuroleptic-naive patients had lower FA scores in the brain compared with controls. There was positive correlation between FA scores and positive symptoms scores in frontotemporal tracts, including left fronto-occipital fasciculus and left inferior longitudinal fasciculus. This implies that white matter dysintegrity is already present in the pre-treatment phase and that FA is likely to decrease after clinical treatment or symptom remission. © 2011 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectDiffusion tensor imagingen_HK
dc.subjectdrug-naiveen_HK
dc.subjectfractional anisotropyen_HK
dc.subjectPANSSen_HK
dc.subjectpsychosisen_HK
dc.subject.meshBrain - ultrastructure-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshSchizophrenia - pathology-
dc.subject.meshSchizophrenic Psychology-
dc.subject.meshTemporal Lobe - ultrastructure-
dc.titlePositive symptoms and white matter microstructure in never-medicated first episode schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailChen, E: eyhchen@hku.hken_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityChen, E=rp00392en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1017/S003329171000156Xen_HK
dc.identifier.pmid20809999-
dc.identifier.scopuseid_2-s2.0-80054996699en_HK
dc.identifier.hkuros187346-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054996699&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1709en_HK
dc.identifier.epage1719en_HK
dc.identifier.isiWOS:000292704400013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridChan, KKS=36448818400en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridDeng, MY=35336436100en_HK
dc.identifier.scopusauthoridTai, KS=7101738949en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridChen, E=7402315729en_HK

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