File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Bioavailable testosterone predicts a lower risk of Alzheimer's disease in older men

TitleBioavailable testosterone predicts a lower risk of Alzheimer's disease in older men
Authors
KeywordsAging
Alzheimer's disease
Chinese
men
testosterone
Issue Date2010
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal Of Alzheimer's Disease, 2010, v. 21 n. 4, p. 1335-1345 How to Cite?
AbstractThere is a paucity of data on the relationship between testosterone and Alzheimer's disease (AD) in older men. The objective of the present study was to investigate the effects of serum total testosterone (TT), bioavailable testosterone (BT), and sex hormone binding globulin (SHBG) levels on the subsequent risk of AD in non-demented Chinese older men. This was a one-year prospective cohort study. 153 ambulatory community-living non-demented Chinese older men, aged 55 years or over, were recruited and followed for one year. Morning serum TT, BT, and SHBG levels were measured at baseline. At one-year of follow-up, assessment for dementia and AD were performed. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD. Overall, the mean age of the subjects was 72.7 (SD 6.9). 6.5% (n = 10) developed dementia (converters), all having AD. 93.5% (n = 143) did not develop dementia (non-converters). Logistic regression analysis for independent predictors of AD showed that the baseline serum BT level, systolic blood pressure (SBP) and ApoE ε4 genotype were significant independent predictors, after adjustment for age, education, BMI, fasting plasma glucose, and serum HDL-C levels. The baseline serum BT level predicted a reduced risk of AD (adjusted relative risk (RR) 0.22, 95% CI: 0.07-0.69)). Baseline SBP and ApoE ε4 genotype but not SHBG were independent risk factors, with RRs of 1.04 and 5.04 respectively. In conclusion, the serum level of bioavailable testosterone in late life predicts a lower risk of future AD development in older men. © 2010 IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/129287
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
Funding AgencyGrant Number
SK Yee Medical Foundation of Hong Kong203205
QMH Charitable Trust
HKU Alzheimer's Disease Research Network of SRT on Healthy Aging
Research Centre of HBHA, Faculty of Medicine, the University of Hong Kong
Funding Information:

Sponsor and funding: SK Yee Medical Foundation of Hong Kong (Project No. 203205), Training and Research Assistance Scheme (TRAS) of the QMH Charitable Trust, HKU Alzheimer's Disease Research Network of SRT on Healthy Aging, and Research Centre of HBHA, Faculty of Medicine, the University of Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChu, LWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, RLCen_HK
dc.contributor.authorYik, PYen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorMorley, JEen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-12-23T08:34:43Z-
dc.date.available2010-12-23T08:34:43Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Alzheimer's Disease, 2010, v. 21 n. 4, p. 1335-1345en_HK
dc.identifier.issn1387-2877en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129287-
dc.description.abstractThere is a paucity of data on the relationship between testosterone and Alzheimer's disease (AD) in older men. The objective of the present study was to investigate the effects of serum total testosterone (TT), bioavailable testosterone (BT), and sex hormone binding globulin (SHBG) levels on the subsequent risk of AD in non-demented Chinese older men. This was a one-year prospective cohort study. 153 ambulatory community-living non-demented Chinese older men, aged 55 years or over, were recruited and followed for one year. Morning serum TT, BT, and SHBG levels were measured at baseline. At one-year of follow-up, assessment for dementia and AD were performed. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD. Overall, the mean age of the subjects was 72.7 (SD 6.9). 6.5% (n = 10) developed dementia (converters), all having AD. 93.5% (n = 143) did not develop dementia (non-converters). Logistic regression analysis for independent predictors of AD showed that the baseline serum BT level, systolic blood pressure (SBP) and ApoE ε4 genotype were significant independent predictors, after adjustment for age, education, BMI, fasting plasma glucose, and serum HDL-C levels. The baseline serum BT level predicted a reduced risk of AD (adjusted relative risk (RR) 0.22, 95% CI: 0.07-0.69)). Baseline SBP and ApoE ε4 genotype but not SHBG were independent risk factors, with RRs of 1.04 and 5.04 respectively. In conclusion, the serum level of bioavailable testosterone in late life predicts a lower risk of future AD development in older men. © 2010 IOS Press and the authors. All rights reserved.en_HK
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_HK
dc.relation.ispartofJournal of Alzheimer's Diseaseen_HK
dc.subjectAgingen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectChineseen_HK
dc.subjectmenen_HK
dc.subjecttestosteroneen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAlzheimer Disease - blood - diagnosis - ethnologyen_HK
dc.subject.meshAsian Continental Ancestry Group - ethnologyen_HK
dc.subject.meshBiological Availabilityen_HK
dc.subject.meshBiological Markers - blooden_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCommunity Health Centers - trendsen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshTestosterone - blooden_HK
dc.titleBioavailable testosterone predicts a lower risk of Alzheimer's disease in older menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1387-2877&volume=21&issue=4&spage=1335&epage=1345&date=2010&atitle=Bioavailable+testosterone+predicts+a+lower+risk+of+Alzheimer%27s+disease+in+older+men-
dc.identifier.emailSong, Y:songy@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/JAD-2010-100027en_HK
dc.identifier.pmid21504130-
dc.identifier.scopuseid_2-s2.0-78650476837en_HK
dc.identifier.hkuros183477en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650476837&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1335en_HK
dc.identifier.epage1345en_HK
dc.identifier.isiWOS:000283049700025-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectA dementia outreach programme in Central, Western and Southern districts of Hong Kong-
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, RLC=26434054000en_HK
dc.identifier.scopusauthoridYik, PY=15060623700en_HK
dc.identifier.scopusauthoridSong, Y=7404921212en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridMorley, JE=7403144221en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats