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Article: Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
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TitleSerum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
 
AuthorsTso, AWK2 1
Lam, TKY2
Xu, A2 1 1
Yiu, KH2
Tse, HF2 1
Li, LSW2 2
Law, LSC2 1
Cheung, BMY2
Cheung, RTF2 1
Lam, KSL2
 
Issue Date2011
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org
 
CitationNeurology, 2011, v. 76 n. 23, p. 1968-1975 [How to Cite?]
DOI: http://dx.doi.org/10.1212/WNL.0b013e31821e54b3
 
AbstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality. Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke. Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p = 0.018), independent of age and NIH Stroke Scale score. Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. Glossary: A-FABP: adipocyte fatty acid-binding proteinBMI: body mass indexCI: confidence intervalCVD: cardiovascular diseaseDM: diabetes mellitusHDL: high-density lipoproteinLDL: low-density lipoproteinNIHSS: NIH Stroke ScaleOR: odds ratioSBP: systolic blood pressure. Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.
 
ISSN0028-3878
2012 Impact Factor: 8.249
2012 SCImago Journal Rankings: 2.580
 
DOIhttp://dx.doi.org/10.1212/WNL.0b013e31821e54b3
 
ISI Accession Number IDWOS:000291343500008
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU7590/06M
CRF HKU 2/07M
Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."
Funding Information:

Supported by the Hong Kong Research Grant Council (GRF HKU7590/06M and CRF HKU 2/07M) and the Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTso, AWK
 
dc.contributor.authorLam, TKY
 
dc.contributor.authorXu, A
 
dc.contributor.authorYiu, KH
 
dc.contributor.authorTse, HF
 
dc.contributor.authorLi, LSW
 
dc.contributor.authorLaw, LSC
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorCheung, RTF
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2010-12-23T08:34:41Z
 
dc.date.available2010-12-23T08:34:41Z
 
dc.date.issued2011
 
dc.description.abstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality. Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke. Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p = 0.018), independent of age and NIH Stroke Scale score. Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. Glossary: A-FABP: adipocyte fatty acid-binding proteinBMI: body mass indexCI: confidence intervalCVD: cardiovascular diseaseDM: diabetes mellitusHDL: high-density lipoproteinLDL: low-density lipoproteinNIHSS: NIH Stroke ScaleOR: odds ratioSBP: systolic blood pressure. Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeurology, 2011, v. 76 n. 23, p. 1968-1975 [How to Cite?]
DOI: http://dx.doi.org/10.1212/WNL.0b013e31821e54b3
 
dc.identifier.doihttp://dx.doi.org/10.1212/WNL.0b013e31821e54b3
 
dc.identifier.eissn1526-632X
 
dc.identifier.epage1975
 
dc.identifier.hkuros183465
 
dc.identifier.hkuros186536
 
dc.identifier.isiWOS:000291343500008
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU7590/06M
CRF HKU 2/07M
Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."
Funding Information:

Supported by the Hong Kong Research Grant Council (GRF HKU7590/06M and CRF HKU 2/07M) and the Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."

 
dc.identifier.issn0028-3878
2012 Impact Factor: 8.249
2012 SCImago Journal Rankings: 2.580
 
dc.identifier.issue23
 
dc.identifier.openurl
 
dc.identifier.pmid21562251
 
dc.identifier.scopuseid_2-s2.0-79958768295
 
dc.identifier.spage1968
 
dc.identifier.urihttp://hdl.handle.net/10722/129286
 
dc.identifier.volume76
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeurology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdipocytes - metabolism - pathology
 
dc.subject.meshBiological Markers - blood
 
dc.subject.meshBrain Ischemia - blood - diagnosis - mortality
 
dc.subject.meshFatty Acid-Binding Proteins - blood
 
dc.subject.meshStroke - blood - diagnosis - mortality
 
dc.titleSerum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
 
dc.typeArticle
 
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<contributor.author>Li, LSW</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong