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Article: Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death

TitleSerum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
Authors
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org
Citation
Neurology, 2011, v. 76 n. 23, p. 1968-1975 How to Cite?
AbstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality. Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke. Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p = 0.018), independent of age and NIH Stroke Scale score. Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. Glossary: A-FABP: adipocyte fatty acid-binding proteinBMI: body mass indexCI: confidence intervalCVD: cardiovascular diseaseDM: diabetes mellitusHDL: high-density lipoproteinLDL: low-density lipoproteinNIHSS: NIH Stroke ScaleOR: odds ratioSBP: systolic blood pressure. Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/129286
ISSN
2015 Impact Factor: 8.166
2015 SCImago Journal Rankings: 3.691
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU7590/06M
CRF HKU 2/07M
Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."
Funding Information:

Supported by the Hong Kong Research Grant Council (GRF HKU7590/06M and CRF HKU 2/07M) and the Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."

References

 

DC FieldValueLanguage
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorLam, TKYen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLi, LSWen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-12-23T08:34:41Z-
dc.date.available2010-12-23T08:34:41Z-
dc.date.issued2011en_HK
dc.identifier.citationNeurology, 2011, v. 76 n. 23, p. 1968-1975en_HK
dc.identifier.issn0028-3878en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129286-
dc.description.abstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality. Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke. Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p = 0.018), independent of age and NIH Stroke Scale score. Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. Glossary: A-FABP: adipocyte fatty acid-binding proteinBMI: body mass indexCI: confidence intervalCVD: cardiovascular diseaseDM: diabetes mellitusHDL: high-density lipoproteinLDL: low-density lipoproteinNIHSS: NIH Stroke ScaleOR: odds ratioSBP: systolic blood pressure. Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.orgen_HK
dc.relation.ispartofNeurologyen_HK
dc.subject.meshAdipocytes - metabolism - pathology-
dc.subject.meshBiological Markers - blood-
dc.subject.meshBrain Ischemia - blood - diagnosis - mortality-
dc.subject.meshFatty Acid-Binding Proteins - blood-
dc.subject.meshStroke - blood - diagnosis - mortality-
dc.titleSerum adipocyte fatty acid-binding protein associated with ischemic stroke and early deathen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-3878&volume=76&issue=23&spage=1968&epage=1975&date=2011&atitle=Serum+adipocyte+fatty+acid-binding+protein+associated+with+ischemic+stroke+and+early+death-
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH: khkyiu@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1212/WNL.0b013e31821e54b3en_HK
dc.identifier.pmid21562251-
dc.identifier.scopuseid_2-s2.0-79958768295en_HK
dc.identifier.hkuros183465en_US
dc.identifier.hkuros186536-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958768295&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue23en_HK
dc.identifier.spage1968en_HK
dc.identifier.epage1975en_HK
dc.identifier.eissn1526-632X-
dc.identifier.isiWOS:000291343500008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridLam, TKY=39863137000en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLi, LSW=35337345300en_HK
dc.identifier.scopusauthoridLaw, LSC=36994511000en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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