Article: Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death

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TitleSerum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
AuthorsTso, AWK1
Lam, TKY1
Xu, A1
Yiu, KH1
Tse, HF1
Li, LSW1
Law, LSC1
Cheung, BMY1
Cheung, RTF1
Lam, KSL1
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org
CitationNeurology, 2011, v. 76 n. 23, p. 1968-1975 [How to Cite?]
DOI: http://dx.doi.org/10.1212/WNL.0b013e31821e54b3
AbstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality. Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke. Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p = 0.018), independent of age and NIH Stroke Scale score. Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. Glossary: A-FABP: adipocyte fatty acid-binding proteinBMI: body mass indexCI: confidence intervalCVD: cardiovascular diseaseDM: diabetes mellitusHDL: high-density lipoproteinLDL: low-density lipoproteinNIHSS: NIH Stroke ScaleOR: odds ratioSBP: systolic blood pressure. Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.
ISSN0028-3878
2011 Impact Factor: 8.312
2011 SCImago Journal Rankings: 0.534
DOIhttp://dx.doi.org/10.1212/WNL.0b013e31821e54b3
ISI Accession Number IDWOS:000291343500008
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU7590/06M
CRF HKU 2/07M
Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."
Funding Information:

Supported by the Hong Kong Research Grant Council (GRF HKU7590/06M and CRF HKU 2/07M) and the Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTso, AWK
dc.contributor.authorLam, TKY
dc.contributor.authorXu, A
dc.contributor.authorYiu, KH
dc.contributor.authorTse, HF
dc.contributor.authorLi, LSW
dc.contributor.authorLaw, LSC
dc.contributor.authorCheung, BMY
dc.contributor.authorCheung, RTF
dc.contributor.authorLam, KSL
dc.date.accessioned2010-12-23T08:34:41Z
dc.date.available2010-12-23T08:34:41Z
dc.date.issued2011
dc.description.abstractObjective: Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality. Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke. Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p = 0.018), independent of age and NIH Stroke Scale score. Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. Glossary: A-FABP: adipocyte fatty acid-binding proteinBMI: body mass indexCI: confidence intervalCVD: cardiovascular diseaseDM: diabetes mellitusHDL: high-density lipoproteinLDL: low-density lipoproteinNIHSS: NIH Stroke ScaleOR: odds ratioSBP: systolic blood pressure. Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeurology, 2011, v. 76 n. 23, p. 1968-1975 [How to Cite?]
DOI: http://dx.doi.org/10.1212/WNL.0b013e31821e54b3
dc.identifier.doihttp://dx.doi.org/10.1212/WNL.0b013e31821e54b3
dc.identifier.epage1975
dc.identifier.hkuros183465
dc.identifier.hkuros186536
dc.identifier.isiWOS:000291343500008
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU7590/06M
CRF HKU 2/07M
Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."
Funding Information:

Supported by the Hong Kong Research Grant Council (GRF HKU7590/06M and CRF HKU 2/07M) and the Stanley Ho Alumni Challenge (first and second years) for "Clinical and experimental stroke research."

dc.identifier.issn0028-3878
2011 Impact Factor: 8.312
2011 SCImago Journal Rankings: 0.534
dc.identifier.issue23
dc.identifier.openurl
dc.identifier.pmid21562251
dc.identifier.scopuseid_2-s2.0-79958768295
dc.identifier.spage1968
dc.identifier.urihttp://hdl.handle.net/10722/129286
dc.identifier.volume76
dc.languageeng
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org
dc.publisher.placeUnited States
dc.relation.ispartofNeurology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdipocytes - metabolism - pathology
dc.subject.meshBiological Markers - blood
dc.subject.meshBrain Ischemia - blood - diagnosis - mortality
dc.subject.meshFatty Acid-Binding Proteins - blood
dc.subject.meshStroke - blood - diagnosis - mortality
dc.titleSerum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong