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Article: Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
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TitleAssociation of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
 
AuthorsOng, KL1
Jiang, CQ2
Liu, B2
Jin, YL2
Tso, AWK1
Tam, S4
Wong, KS5
Tomlinson, B5
Cheung, BMY1
Lin, JM2
Yue, XJ2
Lam, KSL1
Lam, TH1
Thomas, GN3
 
Issue Date2011
 
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
 
CitationClinical Endocrinology, 2011, v. 74 n. 2, p. 206-213 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2265.2010.03899.x
 
AbstractObjective Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 gene (APOA5) are associated with hypertriglyceridaemia in our population. We studied the associations of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. Methods We genotyped five tagging SNPs in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6·4 years; 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. The MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Results The SNP rs662799 (-1131T>C) was associated with the MetS (odds ratio = 1·47, P = 0·00082) and the number of its components present (regression coefficient = 0·204, P = 4·6 á- 10 -5) after adjusting for age, sex, smoking, drinking and education in Hong Kong subjects at baseline. Similar association of this SNP was found in Hong Kong subjects at follow-up (P = 0·010 and 0·00021, respectively) and in Guangzhou subjects (P = 0·0041 and 0·017, respectively). The association of rs662799 with the number of the MetS components was significant regardless of age, sex, obesity and alcohol drinking, but almost disappeared after further adjusting for plasma triglycerides. Conclusion Our results showed that the-1131T>C polymorphism in APOA5 was associated with the MetS because of its strong effect on plasma triglycerides. This may partly explain the higher cardiovascular risk in people with this polymorphism. © 2011 Blackwell Publishing Ltd.
 
ISSN0300-0664
2013 Impact Factor: 3.353
 
DOIhttp://dx.doi.org/10.1111/j.1365-2265.2010.03899.x
 
ISI Accession Number IDWOS:000286005700010
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
National Natural Science Foundation of China/Research Grants Council of Hong Kong30518001/CO301070202
HKU720/05
Funding Information:

The Hong Kong Cardiovascular Risk Factor Prevalence Study-2 was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M), and the Sun Chieh Yeh Heart Foundation. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The genotyping of SNPs was supported by a grant from the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (30518001/CO301070202 and HKU720/05).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorLiu, B
 
dc.contributor.authorJin, YL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorTam, S
 
dc.contributor.authorWong, KS
 
dc.contributor.authorTomlinson, B
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLin, JM
 
dc.contributor.authorYue, XJ
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorLam, TH
 
dc.contributor.authorThomas, GN
 
dc.date.accessioned2010-12-23T08:34:39Z
 
dc.date.available2010-12-23T08:34:39Z
 
dc.date.issued2011
 
dc.description.abstractObjective Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 gene (APOA5) are associated with hypertriglyceridaemia in our population. We studied the associations of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. Methods We genotyped five tagging SNPs in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6·4 years; 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. The MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Results The SNP rs662799 (-1131T>C) was associated with the MetS (odds ratio = 1·47, P = 0·00082) and the number of its components present (regression coefficient = 0·204, P = 4·6 á- 10 -5) after adjusting for age, sex, smoking, drinking and education in Hong Kong subjects at baseline. Similar association of this SNP was found in Hong Kong subjects at follow-up (P = 0·010 and 0·00021, respectively) and in Guangzhou subjects (P = 0·0041 and 0·017, respectively). The association of rs662799 with the number of the MetS components was significant regardless of age, sex, obesity and alcohol drinking, but almost disappeared after further adjusting for plasma triglycerides. Conclusion Our results showed that the-1131T>C polymorphism in APOA5 was associated with the MetS because of its strong effect on plasma triglycerides. This may partly explain the higher cardiovascular risk in people with this polymorphism. © 2011 Blackwell Publishing Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Endocrinology, 2011, v. 74 n. 2, p. 206-213 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2265.2010.03899.x
 
dc.identifier.citeulike8647147
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2265.2010.03899.x
 
dc.identifier.epage213
 
dc.identifier.hkuros183470
 
dc.identifier.isiWOS:000286005700010
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
National Natural Science Foundation of China/Research Grants Council of Hong Kong30518001/CO301070202
HKU720/05
Funding Information:

The Hong Kong Cardiovascular Risk Factor Prevalence Study-2 was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M), and the Sun Chieh Yeh Heart Foundation. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The genotyping of SNPs was supported by a grant from the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (30518001/CO301070202 and HKU720/05).

 
dc.identifier.issn0300-0664
2013 Impact Factor: 3.353
 
dc.identifier.issue2
 
dc.identifier.pmid21054477
 
dc.identifier.scopuseid_2-s2.0-78651264697
 
dc.identifier.spage206
 
dc.identifier.urihttp://hdl.handle.net/10722/129281
 
dc.identifier.volume74
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofClinical Endocrinology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshApolipoproteins A - genetics
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshFemale
 
dc.subject.meshGenetic Predisposition to Disease - genetics
 
dc.subject.meshGenotype
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMetabolic Syndrome X - genetics
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.titleAssociation of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
 
dc.typeArticle
 
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<contributor.author>Jiang, CQ</contributor.author>
<contributor.author>Liu, B</contributor.author>
<contributor.author>Jin, YL</contributor.author>
<contributor.author>Tso, AWK</contributor.author>
<contributor.author>Tam, S</contributor.author>
<contributor.author>Wong, KS</contributor.author>
<contributor.author>Tomlinson, B</contributor.author>
<contributor.author>Cheung, BMY</contributor.author>
<contributor.author>Lin, JM</contributor.author>
<contributor.author>Yue, XJ</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<contributor.author>Lam, TH</contributor.author>
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<description.abstract>Objective Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 gene (APOA5) are associated with hypertriglyceridaemia in our population. We studied the associations of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. Methods We genotyped five tagging SNPs in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6&#183;4 years; 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. The MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Results The SNP rs662799 (-1131T&gt;C) was associated with the MetS (odds ratio = 1&#183;47, P = 0&#183;00082) and the number of its components present (regression coefficient = 0&#183;204, P = 4&#183;6 &#225;- 10 -5) after adjusting for age, sex, smoking, drinking and education in Hong Kong subjects at baseline. Similar association of this SNP was found in Hong Kong subjects at follow-up (P = 0&#183;010 and 0&#183;00021, respectively) and in Guangzhou subjects (P = 0&#183;0041 and 0&#183;017, respectively). The association of rs662799 with the number of the MetS components was significant regardless of age, sex, obesity and alcohol drinking, but almost disappeared after further adjusting for plasma triglycerides. Conclusion Our results showed that the-1131T&gt;C polymorphism in APOA5 was associated with the MetS because of its strong effect on plasma triglycerides. This may partly explain the higher cardiovascular risk in people with this polymorphism. &#169; 2011 Blackwell Publishing Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham
  4. Queen Mary Hospital Hong Kong
  5. Chinese University of Hong Kong