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Article: Determination of mismatched donor HLA in kidney transplant recipients with unknown donor HLA phenotypes

TitleDetermination of mismatched donor HLA in kidney transplant recipients with unknown donor HLA phenotypes
Authors
KeywordsHuman leukocyte antigen (HLA) typing
Kidney transplant
Mismatched human leukocyte antigens
Issue Date2010
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 2010, v. 24 n. 5, p. 178-181 How to Cite?
AbstractObjective: To determine donor human leukocyte antigen (HLA) from renal allograft biopsies in transplant recipients whose donor HLA phenotype is not known. Methods: Renal allograft biopsies were obtained from seven renal transplant recipients when indicated for allograft dysfunction or proteinuria. DNA was extracted fresh from allograft specimens, and HLA typing was performed with polymerase chain reaction-specific sequence primers (PCR-SSP) and polymerase chain reaction-sequence-specific oligonucleotides (PCR-SSO). Results: HLA typing of the seven renal allograft biopsies was composed of both recipient and donor HLA phenotypes, allowing the determination of the donor HLA and the degree of HLA mismatching. Conclusions: Deducing mismatched donor HLA antigens in renal allograft recipients enables detection of donor-specific antibodies, and the management of humoral rejection, and enables more appropriate selection of a donor organ should future retransplantation be required. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/129277
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, Jen_HK
dc.contributor.authorChan, GSWen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorYan, Ten_HK
dc.contributor.authorTang, Len_HK
dc.contributor.authorKwong, KMen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorChan, TMen_HK
dc.date.accessioned2010-12-23T08:34:37Z-
dc.date.available2010-12-23T08:34:37Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical Transplantation, 2010, v. 24 n. 5, p. 178-181en_HK
dc.identifier.issn0902-0063en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129277-
dc.description.abstractObjective: To determine donor human leukocyte antigen (HLA) from renal allograft biopsies in transplant recipients whose donor HLA phenotype is not known. Methods: Renal allograft biopsies were obtained from seven renal transplant recipients when indicated for allograft dysfunction or proteinuria. DNA was extracted fresh from allograft specimens, and HLA typing was performed with polymerase chain reaction-specific sequence primers (PCR-SSP) and polymerase chain reaction-sequence-specific oligonucleotides (PCR-SSO). Results: HLA typing of the seven renal allograft biopsies was composed of both recipient and donor HLA phenotypes, allowing the determination of the donor HLA and the degree of HLA mismatching. Conclusions: Deducing mismatched donor HLA antigens in renal allograft recipients enables detection of donor-specific antibodies, and the management of humoral rejection, and enables more appropriate selection of a donor organ should future retransplantation be required. © 2010 John Wiley & Sons A/S.en_HK
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTRen_HK
dc.relation.ispartofClinical Transplantationen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectHuman leukocyte antigen (HLA) typingen_HK
dc.subjectKidney transplanten_HK
dc.subjectMismatched human leukocyte antigensen_HK
dc.subject.meshDNA - analysis - genetics-
dc.subject.meshFeasibility Studies-
dc.subject.meshGraft Rejection - genetics - immunology-
dc.subject.meshHLA Antigens - genetics - immunology-
dc.subject.meshKidney Transplantation - immunology-
dc.titleDetermination of mismatched donor HLA in kidney transplant recipients with unknown donor HLA phenotypesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0902-0063&volume=24&issue=5&spage=E178&epage=E181&date=2010&atitle=Determination+of+mismatched+donor+HLA+in+kidney+transplant+recipients+with+unknown+donor+HLA+phenotypes-
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1399-0012.2010.01246.xen_HK
dc.identifier.pmid20384732-
dc.identifier.scopuseid_2-s2.0-78650465656en_HK
dc.identifier.hkuros178491en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650465656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue5en_HK
dc.identifier.spage178en_HK
dc.identifier.epage181en_HK
dc.identifier.isiWOS:000282570300008-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridKwok, J=7006208874en_HK
dc.identifier.scopusauthoridChan, GSW=7202355321en_HK
dc.identifier.scopusauthoridLam, MF=35300050600en_HK
dc.identifier.scopusauthoridYan, T=37038735600en_HK
dc.identifier.scopusauthoridTang, L=37038625000en_HK
dc.identifier.scopusauthoridKwong, KM=37037782800en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.citeulike8015949-

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