File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese
  • Basic View
  • Metadata View
  • XML View
TitleA genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese
 
AuthorsOng, KL1
Tso, AWK1
Leung, RYH1
Cherny, SS1
Sham, PC1
Lam, TH1
Cheung, BMY1
Lam, KSL1
 
KeywordsAdrenomedullin
Dysglycemia
Single nucleotide polymorphism
 
Issue Date2011
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca
 
CitationClinica Chimica Acta, 2011, v. 412 n. 3-4, p. 353-357 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.cca.2010.11.007
 
AbstractBackground: Adrenomedullin, a vasodilatory peptide, facilitates the differentiation of pre-adipocytes, and affects lipolysis and glucose uptake. We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population. Methods: Four SNPs were genotyped in 1391 subjects without dysglycemia at baseline from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, which had a median follow-up time of 6.4. years. Dysglycemia included impaired fasting glucose, impaired glucose tolerance, and diabetes according to the WHO 1998 criteria. At follow-up, 382 subjects had developed dysglycemia. Results: In stepwise logistic regression, the SNP rs11042725 was a significant independent predictor of the development of dysglycemia (OR=1.31, P=0.012), together with baseline age (P< 0.001), plasma triglycerides (P< 0.001), body mass index (P=0.004), 2-h glucose after oral glucose tolerance test (P< 0.001), homeostasis model assessment of insulin resistance index (P=0.045), and follow-up duration (P=0.009). The association was more significant in women (P=0.002) and in subjects without regular exercise (P=0.001). Conclusions: Our study suggests a potential role of genetic variants in the ADM gene in the development of dysglycemia in our local Chinese population. © 2010 Elsevier B.V.
 
ISSN0009-8981
2012 Impact Factor: 2.85
2012 SCImago Journal Rankings: 0.795
 
DOIhttp://dx.doi.org/10.1016/j.cca.2010.11.007
 
ISI Accession Number IDWOS:000287115400024
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7229/01 M
HKU7626/07 M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grant Council grants (HKU7229/01 M and HKU7626/07 M), and the Sun Chieh Yeh Heart Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2010-12-23T08:34:34Z
 
dc.date.available2010-12-23T08:34:34Z
 
dc.date.issued2011
 
dc.description.abstractBackground: Adrenomedullin, a vasodilatory peptide, facilitates the differentiation of pre-adipocytes, and affects lipolysis and glucose uptake. We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population. Methods: Four SNPs were genotyped in 1391 subjects without dysglycemia at baseline from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, which had a median follow-up time of 6.4. years. Dysglycemia included impaired fasting glucose, impaired glucose tolerance, and diabetes according to the WHO 1998 criteria. At follow-up, 382 subjects had developed dysglycemia. Results: In stepwise logistic regression, the SNP rs11042725 was a significant independent predictor of the development of dysglycemia (OR=1.31, P=0.012), together with baseline age (P< 0.001), plasma triglycerides (P< 0.001), body mass index (P=0.004), 2-h glucose after oral glucose tolerance test (P< 0.001), homeostasis model assessment of insulin resistance index (P=0.045), and follow-up duration (P=0.009). The association was more significant in women (P=0.002) and in subjects without regular exercise (P=0.001). Conclusions: Our study suggests a potential role of genetic variants in the ADM gene in the development of dysglycemia in our local Chinese population. © 2010 Elsevier B.V.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinica Chimica Acta, 2011, v. 412 n. 3-4, p. 353-357 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.cca.2010.11.007
 
dc.identifier.citeulike8266126
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.cca.2010.11.007
 
dc.identifier.epage357
 
dc.identifier.hkuros183469
 
dc.identifier.isiWOS:000287115400024
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7229/01 M
HKU7626/07 M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grant Council grants (HKU7229/01 M and HKU7626/07 M), and the Sun Chieh Yeh Heart Foundation.

 
dc.identifier.issn0009-8981
2012 Impact Factor: 2.85
2012 SCImago Journal Rankings: 0.795
 
dc.identifier.issue3-4
 
dc.identifier.openurl
 
dc.identifier.pmid21075100
 
dc.identifier.scopuseid_2-s2.0-78650237267
 
dc.identifier.spage353
 
dc.identifier.urihttp://hdl.handle.net/10722/129273
 
dc.identifier.volume412
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofClinica Chimica Acta
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAppropriate Bibliographic Citation:Authors posting Accepted Author Manuscript online should later add a citation for the Published Journal Article indicating that the Article was subsequently published, and may mention the journal title provided that they add the following text at the beginning of the document: “NOTICE: this is the author’s version of a work that was accepted for publication in . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#”
 
dc.subjectAdrenomedullin
 
dc.subjectDysglycemia
 
dc.subjectSingle nucleotide polymorphism
 
dc.titleA genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Ong, KL</contributor.author>
<contributor.author>Tso, AWK</contributor.author>
<contributor.author>Leung, RYH</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Cheung, BMY</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<date.accessioned>2010-12-23T08:34:34Z</date.accessioned>
<date.available>2010-12-23T08:34:34Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Clinica Chimica Acta, 2011, v. 412 n. 3-4, p. 353-357</identifier.citation>
<identifier.issn>0009-8981</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/129273</identifier.uri>
<description.abstract>Background: Adrenomedullin, a vasodilatory peptide, facilitates the differentiation of pre-adipocytes, and affects lipolysis and glucose uptake. We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population. Methods: Four SNPs were genotyped in 1391 subjects without dysglycemia at baseline from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, which had a median follow-up time of 6.4. years. Dysglycemia included impaired fasting glucose, impaired glucose tolerance, and diabetes according to the WHO 1998 criteria. At follow-up, 382 subjects had developed dysglycemia. Results: In stepwise logistic regression, the SNP rs11042725 was a significant independent predictor of the development of dysglycemia (OR=1.31, P=0.012), together with baseline age (P&lt; 0.001), plasma triglycerides (P&lt; 0.001), body mass index (P=0.004), 2-h glucose after oral glucose tolerance test (P&lt; 0.001), homeostasis model assessment of insulin resistance index (P=0.045), and follow-up duration (P=0.009). The association was more significant in women (P=0.002) and in subjects without regular exercise (P=0.001). Conclusions: Our study suggests a potential role of genetic variants in the ADM gene in the development of dysglycemia in our local Chinese population. &#169; 2010 Elsevier B.V.</description.abstract>
<language>eng</language>
<publisher>Elsevier BV. The Journal&apos;s web site is located at http://www.elsevier.com/locate/cca</publisher>
<relation.ispartof>Clinica Chimica Acta</relation.ispartof>
<rights>Appropriate Bibliographic Citation:Authors posting Accepted Author Manuscript online should later add a citation for the Published Journal Article indicating that the Article was subsequently published, and may mention the journal title provided that they add the following text at the beginning of the document:

&#8220;NOTICE: this is the author&#8217;s version of a work that was accepted for publication in &lt;Journal title&gt;. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#&#8221;</rights>
<subject>Adrenomedullin</subject>
<subject>Dysglycemia</subject>
<subject>Single nucleotide polymorphism</subject>
<title>A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0009-8981&amp;volume=412&amp;issue=3-4&amp;spage=353&amp;epage=357&amp;date=2010&amp;atitle=A+genetic+variant+in+the+gene+encoding+adrenomedullin+predicts+the+development+of+dysglycemia+over+6.4+years+in+Chinese</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.cca.2010.11.007</identifier.doi>
<identifier.pmid>21075100</identifier.pmid>
<identifier.scopus>eid_2-s2.0-78650237267</identifier.scopus>
<identifier.hkuros>183469</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-78650237267&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>412</identifier.volume>
<identifier.issue>3-4</identifier.issue>
<identifier.spage>353</identifier.spage>
<identifier.epage>357</identifier.epage>
<identifier.isi>WOS:000287115400024</identifier.isi>
<publisher.place>Netherlands</publisher.place>
<identifier.citeulike>8266126</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong