Article: A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese
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- Publisher Website: 10.1016/j.cca.2010.11.007
- Scopus: eid_2-s2.0-78650237267
- PMID: 21075100
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| Title | A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Ong, KL1 Tso, AWK1 Leung, RYH1 Cherny, SS1 Sham, PC1 Lam, TH1 Cheung, BMY1 Lam, KSL1 | ||||||
| Keywords | Adrenomedullin Dysglycemia Single nucleotide polymorphism | ||||||
| Issue Date | 2011 | ||||||
| Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca | ||||||
| Citation | Clinica Chimica Acta, 2011, v. 412 n. 3-4, p. 353-357 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.cca.2010.11.007 | ||||||
| Abstract | Background: Adrenomedullin, a vasodilatory peptide, facilitates the differentiation of pre-adipocytes, and affects lipolysis and glucose uptake. We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population. Methods: Four SNPs were genotyped in 1391 subjects without dysglycemia at baseline from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, which had a median follow-up time of 6.4. years. Dysglycemia included impaired fasting glucose, impaired glucose tolerance, and diabetes according to the WHO 1998 criteria. At follow-up, 382 subjects had developed dysglycemia. Results: In stepwise logistic regression, the SNP rs11042725 was a significant independent predictor of the development of dysglycemia (OR=1.31, P=0.012), together with baseline age (P< 0.001), plasma triglycerides (P< 0.001), body mass index (P=0.004), 2-h glucose after oral glucose tolerance test (P< 0.001), homeostasis model assessment of insulin resistance index (P=0.045), and follow-up duration (P=0.009). The association was more significant in women (P=0.002) and in subjects without regular exercise (P=0.001). Conclusions: Our study suggests a potential role of genetic variants in the ADM gene in the development of dysglycemia in our local Chinese population. © 2010 Elsevier B.V. | ||||||
| ISSN | 0009-8981 2011 Impact Factor: 2.535 2011 SCImago Journal Rankings: 0.189 | ||||||
| DOI | http://dx.doi.org/10.1016/j.cca.2010.11.007 | ||||||
| ISI Accession Number ID | WOS:000287115400024
Funding Information: This study was funded by Hong Kong Research Grant Council grants (HKU7229/01 M and HKU7626/07 M), and the Sun Chieh Yeh Heart Foundation. | ||||||
| References | References in Scopus |
| dc.contributor.author | Ong, KL | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Tso, AWK | ||||||
| dc.contributor.author | Leung, RYH | ||||||
| dc.contributor.author | Cherny, SS | ||||||
| dc.contributor.author | Sham, PC | ||||||
| dc.contributor.author | Lam, TH | ||||||
| dc.contributor.author | Cheung, BMY | ||||||
| dc.contributor.author | Lam, KSL | ||||||
| dc.date.accessioned | 2010-12-23T08:34:34Z | ||||||
| dc.date.available | 2010-12-23T08:34:34Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Background: Adrenomedullin, a vasodilatory peptide, facilitates the differentiation of pre-adipocytes, and affects lipolysis and glucose uptake. We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population. Methods: Four SNPs were genotyped in 1391 subjects without dysglycemia at baseline from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, which had a median follow-up time of 6.4. years. Dysglycemia included impaired fasting glucose, impaired glucose tolerance, and diabetes according to the WHO 1998 criteria. At follow-up, 382 subjects had developed dysglycemia. Results: In stepwise logistic regression, the SNP rs11042725 was a significant independent predictor of the development of dysglycemia (OR=1.31, P=0.012), together with baseline age (P< 0.001), plasma triglycerides (P< 0.001), body mass index (P=0.004), 2-h glucose after oral glucose tolerance test (P< 0.001), homeostasis model assessment of insulin resistance index (P=0.045), and follow-up duration (P=0.009). The association was more significant in women (P=0.002) and in subjects without regular exercise (P=0.001). Conclusions: Our study suggests a potential role of genetic variants in the ADM gene in the development of dysglycemia in our local Chinese population. © 2010 Elsevier B.V. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Clinica Chimica Acta, 2011, v. 412 n. 3-4, p. 353-357 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.cca.2010.11.007 | ||||||
| dc.identifier.citeulike | 8266126 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.cca.2010.11.007 | ||||||
| dc.identifier.epage | 357 | ||||||
| dc.identifier.hkuros | 183469 | ||||||
| dc.identifier.isi | WOS:000287115400024
Funding Information: This study was funded by Hong Kong Research Grant Council grants (HKU7229/01 M and HKU7626/07 M), and the Sun Chieh Yeh Heart Foundation. | ||||||
| dc.identifier.issn | 0009-8981 2011 Impact Factor: 2.535 2011 SCImago Journal Rankings: 0.189 | ||||||
| dc.identifier.issue | 3-4 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 21075100 | ||||||
| dc.identifier.scopus | eid_2-s2.0-78650237267 | ||||||
| dc.identifier.spage | 353 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/129273 | ||||||
| dc.identifier.volume | 412 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca | ||||||
| dc.publisher.place | Netherlands | ||||||
| dc.relation.ispartof | Clinica Chimica Acta | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Appropriate Bibliographic Citation:Authors posting Accepted Author Manuscript online should later add a citation for the Published Journal Article indicating that the Article was subsequently published, and may mention the journal title provided that they add the following text at the beginning of the document:
“NOTICE: this is the author’s version of a work that was accepted for publication in | ||||||
| dc.subject | Adrenomedullin | ||||||
| dc.subject | Dysglycemia | ||||||
| dc.subject | Single nucleotide polymorphism | ||||||
| dc.title | A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong