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Article: Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells

TitleRegeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells
Authors
Issue Date2009
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/WRR
Citation
Wound Repair and Regeneration, 2009, v. 17, p. 427-435 How to Cite?
AbstractRegeneration of sweat glands after deep burns has been an unsolved problem. Owing to lack of perspiration, survivors of an extensive deep burn injury are leading a miserable life in sultry months. It was our contemplation to solve this problem by inducing bone marrow mesenchymal stem cells (MSCs) to acquire the phenotype of sweat gland cells in vitro. Then these cells were transplanted into fresh skin wounds resulting from excision of anhydrotic scars after healing of deep burn injury in five patients. Two to 12 months after the procedure, it was proved that there was recovery of perspiration function in all the MSCs' transplanted areas, as evidenced by positive iodine-starch perspiration test. Histological and biochemical observation confirmed the involvement of MSCs transformed sweat gland cells in the recovery of functional sweat glands, and the components of sweat collected from these areas were similar to that collected from normal skin. This is the first report of successful transplantation of MSCs in regenerating functional sweat glands, which may help solve the problem of depletion of sweat glands in patients surviving extensive deep burns in the future.
Persistent Identifierhttp://hub.hku.hk/handle/10722/128963
ISSN
2015 Impact Factor: 2.628
2015 SCImago Journal Rankings: 1.149
ISI Accession Number ID
Funding AgencyGrant Number
National Basic and Development Programme2005CB522603
National Natural Science Foundation in China30670966
30730090
Medical Research Programme from Army06G116
Funding Information:

Competing Interests Statement: The authors declare that they have no competing financial interests.

 

DC FieldValueLanguage
dc.contributor.authorSheng, Z-
dc.contributor.authorFu, X-
dc.contributor.authorCai, S-
dc.contributor.authorLei, Y-
dc.contributor.authorSun, T-
dc.contributor.authorBai, X-
dc.contributor.authorChen, M-
dc.date.accessioned2010-11-25T06:25:19Z-
dc.date.available2010-11-25T06:25:19Z-
dc.date.issued2009-
dc.identifier.citationWound Repair and Regeneration, 2009, v. 17, p. 427-435-
dc.identifier.issn1067-1927-
dc.identifier.urihttp://hub.hku.hk/handle/10722/128963-
dc.description.abstractRegeneration of sweat glands after deep burns has been an unsolved problem. Owing to lack of perspiration, survivors of an extensive deep burn injury are leading a miserable life in sultry months. It was our contemplation to solve this problem by inducing bone marrow mesenchymal stem cells (MSCs) to acquire the phenotype of sweat gland cells in vitro. Then these cells were transplanted into fresh skin wounds resulting from excision of anhydrotic scars after healing of deep burn injury in five patients. Two to 12 months after the procedure, it was proved that there was recovery of perspiration function in all the MSCs' transplanted areas, as evidenced by positive iodine-starch perspiration test. Histological and biochemical observation confirmed the involvement of MSCs transformed sweat gland cells in the recovery of functional sweat glands, and the components of sweat collected from these areas were similar to that collected from normal skin. This is the first report of successful transplantation of MSCs in regenerating functional sweat glands, which may help solve the problem of depletion of sweat glands in patients surviving extensive deep burns in the future.-
dc.languageeng-
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/WRR-
dc.relation.ispartofWound Repair and Regeneration-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshBone Marrow Cells - cytology-
dc.subject.meshBurns - pathology - surgery-
dc.subject.meshMesenchymal Stem Cell Transplantation - methods-
dc.subject.meshRegeneration - physiology-
dc.subject.meshSweat Glands - physiology - surgery-
dc.titleRegeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1067-1927&volume=17&spage=427&epage=435&date=2009&atitle=Regeneration+of+functional+sweat+gland-like+structures+by+transplanted+differentiated+bone+marrow+mesenchymal+stem+cells-
dc.identifier.emailCai, S: caisa@HKUCC-COM.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1524-475X.2009.00474.x-
dc.identifier.pmid19660052-
dc.identifier.scopuseid_2-s2.0-65949095665-
dc.identifier.hkuros180799-
dc.identifier.volume17-
dc.identifier.spage427-
dc.identifier.epage435-
dc.identifier.isiWOS:000266244600019-
dc.identifier.citeulike4627162-

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