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Article: Dedifferentiation: A new approach in stem cell research

TitleDedifferentiation: A new approach in stem cell research
Authors
KeywordsCells
Stem cells
Dedifferentiation
Regeneration
Signaling pathways
Issue Date2007
PublisherAmerican Institute of Biological Sciences. The Journal's web site is located at http://www.aibs.org
Citation
Bioscience, 2007, v. 57 n. 8, p. 655-622 How to Cite?
AbstractDedifferentiation is an important biological phenomenon whereby cells regress from a specialized function to a simpler state reminiscent of stem cells. Stem cells are self-renewing cells capable of giving rise to differentiated cells when supplied with the appropriate factors. Stem cells that are derived by dedifferentiation of one's own cells could be a new resource for regenerative medicine, one that poses no risk of genetic incompatibility or immune rejection and provokes fewer ethical debates than the use of stem cells derived from embryonic tissue. Until now, it has not been quite clear why some differentiated cell types can dedifferentiate and proliferate, whereas others cannot. A better understanding of the mechanisms involved in dedifferentiation may enable scientists to control and possibly alter the plasticity of the differentiated state, which may lead to benefits not only in stem cell research but also in regenerative medicine and even tumor biology. If so, dedifferentiation will offer an ethically acceptable alternative route to obtain an abundant source of stem cells. Dedifferentiation is likely to become a new focus of stem cell research. Here we compile recent advances in this emerging but significant research, highlighting its central concepts, research findings, possible signaling pathways, and potential applications.
Persistent Identifierhttp://hub.hku.hk/handle/10722/128962
ISSN
2015 Impact Factor: 4.294
2015 SCImago Journal Rankings: 2.374
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCai, S-
dc.contributor.authorFu, X-
dc.contributor.authorSheng, Z-
dc.date.accessioned2010-11-25T01:36:40Z-
dc.date.available2010-11-25T01:36:40Z-
dc.date.issued2007-
dc.identifier.citationBioscience, 2007, v. 57 n. 8, p. 655-622-
dc.identifier.issn0006-3568-
dc.identifier.urihttp://hub.hku.hk/handle/10722/128962-
dc.description.abstractDedifferentiation is an important biological phenomenon whereby cells regress from a specialized function to a simpler state reminiscent of stem cells. Stem cells are self-renewing cells capable of giving rise to differentiated cells when supplied with the appropriate factors. Stem cells that are derived by dedifferentiation of one's own cells could be a new resource for regenerative medicine, one that poses no risk of genetic incompatibility or immune rejection and provokes fewer ethical debates than the use of stem cells derived from embryonic tissue. Until now, it has not been quite clear why some differentiated cell types can dedifferentiate and proliferate, whereas others cannot. A better understanding of the mechanisms involved in dedifferentiation may enable scientists to control and possibly alter the plasticity of the differentiated state, which may lead to benefits not only in stem cell research but also in regenerative medicine and even tumor biology. If so, dedifferentiation will offer an ethically acceptable alternative route to obtain an abundant source of stem cells. Dedifferentiation is likely to become a new focus of stem cell research. Here we compile recent advances in this emerging but significant research, highlighting its central concepts, research findings, possible signaling pathways, and potential applications.-
dc.languageeng-
dc.publisherAmerican Institute of Biological Sciences. The Journal's web site is located at http://www.aibs.org-
dc.relation.ispartofBioscience-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsBioscience. Copyright © American Institute of Biological Sciences.-
dc.subjectCells-
dc.subjectStem cells-
dc.subjectDedifferentiation-
dc.subjectRegeneration-
dc.subjectSignaling pathways-
dc.titleDedifferentiation: A new approach in stem cell researchen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3568&volume=57&issue=8&spage=655&epage=622&date=2007&atitle=Dedifferentiation:+A+new+approach+in+stem+cell+research-
dc.identifier.emailCai, S: ciasa@hkucc-com.hku.hk-
dc.identifier.emailFu, X: fuxiaobing@vip.sina.com-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1641/B570805-
dc.identifier.scopuseid_2-s2.0-34548683738-
dc.identifier.hkuros180794-
dc.identifier.volume57-
dc.identifier.issue8-
dc.identifier.spage655-
dc.identifier.epage622-
dc.identifier.isiWOS:000249510700007-
dc.identifier.citeulike1720949-

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