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Article: Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats

TitleHepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
Citation
Chinese Medicine, 2010, v. 5, article no. 33 How to Cite?
AbstractBackground: Berberine is an active compound in Coptidis Rhizoma (Huanglian) with multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, cholesterol-lowering and anticancer effects. The present study aims to determine the hepatoprotective effects of berberine on serum and tissue superoxide dismutase (SOD) levels, the histology in tetrachloride (CCl 4)-induced liver injury.Methods: Sprague-Dawley rats aged seven weeks were injected intraperitoneally with 50% CCl 4 in olive oil. Berberine was orally administered before or after CCl 4 treatment in various groups. Twenty-four hours after CCl 4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured. Histological changes of liver were examined with microscopy.Results: Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with berberine. Berberine increased the SOD activity in liver. Histological examination showed lowered liver damage in berberine-treated groups.Conclusion: The present study demonstrates that berberine possesses hepatoprotective effects against CCl 4-induced hepatotoxicity and that the effects are both preventive and curative. Berberine should have potential for developing a new drug to treat liver toxicity. © 2010 Feng et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/127604
ISSN
2015 Impact Factor: 1.58
2015 SCImago Journal Rankings: 0.655
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorFeng, Yen_HK
dc.contributor.authorSiu, KYen_HK
dc.contributor.authorYe, Xen_HK
dc.contributor.authorWang, Nen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorKobayashi, Sen_HK
dc.date.accessioned2010-10-31T13:35:10Z-
dc.date.available2010-10-31T13:35:10Z-
dc.date.issued2010en_HK
dc.identifier.citationChinese Medicine, 2010, v. 5, article no. 33en_HK
dc.identifier.issn1749-8546en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127604-
dc.description.abstractBackground: Berberine is an active compound in Coptidis Rhizoma (Huanglian) with multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, cholesterol-lowering and anticancer effects. The present study aims to determine the hepatoprotective effects of berberine on serum and tissue superoxide dismutase (SOD) levels, the histology in tetrachloride (CCl 4)-induced liver injury.Methods: Sprague-Dawley rats aged seven weeks were injected intraperitoneally with 50% CCl 4 in olive oil. Berberine was orally administered before or after CCl 4 treatment in various groups. Twenty-four hours after CCl 4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured. Histological changes of liver were examined with microscopy.Results: Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with berberine. Berberine increased the SOD activity in liver. Histological examination showed lowered liver damage in berberine-treated groups.Conclusion: The present study demonstrates that berberine possesses hepatoprotective effects against CCl 4-induced hepatotoxicity and that the effects are both preventive and curative. Berberine should have potential for developing a new drug to treat liver toxicity. © 2010 Feng et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/homeen_HK
dc.relation.ispartofChinese Medicineen_HK
dc.rightsChinese Medicine. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleHepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1749-8546&volume=5, article no. 33&spage=&epage=&date=2010&atitle=Hepatoprotective+effects+of+berberine+on+carbon+tetrachloride-induced+acute+hepatotoxicity+in+ratsen_HK
dc.identifier.emailFeng, Y: yfeng@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.emailLeung, CH: duncanl@hkucc.hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.authorityFeng, Y=rp00466en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1749-8546-5-33en_HK
dc.identifier.pmid20849653-
dc.identifier.pmcidPMC2949732-
dc.identifier.scopuseid_2-s2.0-77956585004en_HK
dc.identifier.hkuros183035en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956585004&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5, article no. 33en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridFeng, Y=24467969600en_HK
dc.identifier.scopusauthoridSiu, KY=26026052800en_HK
dc.identifier.scopusauthoridYe, X=35277763000en_HK
dc.identifier.scopusauthoridWang, N=35072317700en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridKobayashi, S=8083633200en_HK

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