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Article: Protective effect of Dendrobium officinale polysaccharides on experimental Sjogren's syndrome

TitleProtective effect of Dendrobium officinale polysaccharides on experimental Sjogren's syndrome
Authors
KeywordsApoptosis
AQP5
Dendrobium officinale
Polysaccharides
Sjogren's syndrome
Issue Date2010
PublisherBerkeley Electronic Press. The Journal's web site is located at http://www.bepress.com/jcim
Citation
Journal Of Complementary And Integrative Medicine, 2010, v. 7 n. 1 How to Cite?
AbstractSjogren's syndrome (SS), usually described as a chronic inflammation which results in xerostomia (dry mouth) and xerophthalmia (dry eyes). According to the theory of traditional Chinese medicine, body fluid impairment causes the dryness, inducing water secretion deficiency. Discovery of a family of water-specific membrane channel proteins, the aquaporins, provides an interesting molecular mechanism of water permeability and transportation which were found abnormal in tissues of SS patients. Thus, this dryness may lead to the dysfunction in organs as various systematic manifestations. We established an autoallergic mouse model in vivo, and human salivary gland cell line A-253 in vitro. Polysaccharides of Dendrobium officinale (DP) were administrated as treatment, which was described to nourish yin and promote the body fluid. Results showed that immunization with SG autoantigen induced decrease of body weight and increased water intake, decreased AQP5 expression in a series of organs related to body fluid. Sera from model mice induced apoptosis of A-253 cells with activation of caspase-3. Administration of DP could reverse these pathological changes in both the animal and cell model. Thus, DP may be a promising candidate for the treatment of SS by up-regulating the expression of AQP-5 and protecting cells from apoptosis. © 2010 The Berkeley Electronic Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/127601
ISSN
2015 SCImago Journal Rankings: 0.401
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Xen_HK
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorFeng, Yen_HK
dc.contributor.authorChen, JPen_HK
dc.contributor.authorNg, TBen_HK
dc.contributor.authorLin, Xen_HK
dc.contributor.authorShaw, PCen_HK
dc.contributor.authorZhang, KYen_HK
dc.date.accessioned2010-10-31T13:35:00Z-
dc.date.available2010-10-31T13:35:00Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Complementary And Integrative Medicine, 2010, v. 7 n. 1en_HK
dc.identifier.issn1553-3840en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127601-
dc.description.abstractSjogren's syndrome (SS), usually described as a chronic inflammation which results in xerostomia (dry mouth) and xerophthalmia (dry eyes). According to the theory of traditional Chinese medicine, body fluid impairment causes the dryness, inducing water secretion deficiency. Discovery of a family of water-specific membrane channel proteins, the aquaporins, provides an interesting molecular mechanism of water permeability and transportation which were found abnormal in tissues of SS patients. Thus, this dryness may lead to the dysfunction in organs as various systematic manifestations. We established an autoallergic mouse model in vivo, and human salivary gland cell line A-253 in vitro. Polysaccharides of Dendrobium officinale (DP) were administrated as treatment, which was described to nourish yin and promote the body fluid. Results showed that immunization with SG autoantigen induced decrease of body weight and increased water intake, decreased AQP5 expression in a series of organs related to body fluid. Sera from model mice induced apoptosis of A-253 cells with activation of caspase-3. Administration of DP could reverse these pathological changes in both the animal and cell model. Thus, DP may be a promising candidate for the treatment of SS by up-regulating the expression of AQP-5 and protecting cells from apoptosis. © 2010 The Berkeley Electronic Press. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBerkeley Electronic Press. The Journal's web site is located at http://www.bepress.com/jcimen_HK
dc.relation.ispartofJournal of Complementary and Integrative Medicineen_HK
dc.rightsJournal of Complementary & Integrative Medicine. Copyright © Berkeley Electronic Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectApoptosisen_HK
dc.subjectAQP5en_HK
dc.subjectDendrobium officinaleen_HK
dc.subjectPolysaccharidesen_HK
dc.subjectSjogren's syndromeen_HK
dc.titleProtective effect of Dendrobium officinale polysaccharides on experimental Sjogren's syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1553-3840&volume=7&issue=1 article no. 14&spage=&epage=&date=2010&atitle=Protective+effect+of+Dendrobium+officinale+polysaccharides+on+experimental+Sjogren%27s+syndrome-
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailZhang, Z: zhangzj@hkucc.hku.hken_HK
dc.identifier.emailFeng, Y: yfeng@hku.hken_HK
dc.identifier.emailChen, JP: abchen@hku.hken_HK
dc.identifier.emailZhang, KY: ybzhang@hku.hken_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityZhang, Z=rp01297en_HK
dc.identifier.authorityFeng, Y=rp00466en_HK
dc.identifier.authorityChen, JP=rp01316en_HK
dc.identifier.authorityZhang, KY=rp01410en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2202/1553-3840.1342en_HK
dc.identifier.scopuseid_2-s2.0-77952047770en_HK
dc.identifier.hkuros174206en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952047770&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLin, X=36101204400en_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridZhang, Z=8061473900en_HK
dc.identifier.scopusauthoridFeng, Y=24467969600en_HK
dc.identifier.scopusauthoridChen, JP=22733695400en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK
dc.identifier.scopusauthoridLin, X=55222409500en_HK
dc.identifier.scopusauthoridShaw, PC=35599523600en_HK
dc.identifier.scopusauthoridZhang, KY=23483121900en_HK

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