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Conference Paper: Declined frontal white matter integrity in Alzheimer’s disease: a diffusion tensor imaging study

TitleDeclined frontal white matter integrity in Alzheimer’s disease: a diffusion tensor imaging study
Authors
KeywordsMedical sciences
Issue Date2010
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 15th Medical Research Conference (MRC 2010), Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 suppl 1, p. 21, abstract no. 26 How to Cite?
AbstractINTRODUCTION: Previous studies on structural changes of Alzheimer’s disease (AD) have been focused on grey matter atrophy. There is a resurgence of interests on white matter integrity in this prominently increasing patient population. Diffusion tensor imaging (DTI) provides key information on the microstructural changes beyond macroscopic anatomical imaging by in-vivo tracing molecular diffusion in the brain, and the measured fractional anisotrophy (FA) value may represent axonal integrity of neuronal networks. Data of DTI from AD patients are limited, and the literature is controversial regarding whether the AD process has a greater impact on anterior versus posterior cerebral white matter. METHODS: Eighteen patients with mild AD and 16 age-matched healthy adults were recruited into the study. Demographic features of the two groups were comparable. Data of DTI were collected using a Philips 3.0T MRI scanner. Scan parameters were as follows: B0=800 s/mm2, FOV=224*224*140 mm, resolution=1.75*1.75*2 mm, non-collinear 15 directions was acquired. 3D T1 anatomy was also collected. We processed DTI data with DTI toolbox, and anatomical T1 data with VBM5 toolbox in SPM. Voxel-by-voxel analysis was applied to compare the difference in FA value, and volume of white matter of the normalised brain between the elderly and AD groups. RESULTS: Voxel-based analysis showed no significant difference in white matter volume between the two groups, but FA value was reduced greatly in the left anterior cingulate (−10,37,−3), right anterior cingulate (12,0,28), and left medial frontal lobe (−18,32,−12). Minor reduction was found in other brain regions such as body of the corpus callosum, right midbrain (12,−12,−6), right posterior corpus callosum (8,−44,2), and bilateral, especially right temporal lobe (36,−8,−20), upon right hippocampus. Coordinates (x,y,z) were labelled according to Talairach atlas. CONCLUSION: DTI could be valid and more sensitive than traditional T1 anatomy in detecting microscopic white matter lesions. Our data showed a greater decrement in FA value over the anterior than posterior brain regions, and this decrement was not due to white matter atrophy. Our findings are in line with the retrogenesis hypothesis which predicts reversed demyelination during the process of AD, as the frontal lobe fibres are myelinated relatively late during brain development. These results also support previous findings of our behavioural study that frontal lobe abnormality might be the neural basis for cognitive deficit in AD patients.
Persistent Identifierhttp://hdl.handle.net/10722/127167
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorGao, Jen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorChu, LWen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorQiu, Den_HK
dc.contributor.authorMak, Hen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-10-31T13:10:01Z-
dc.date.available2010-10-31T13:10:01Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 15th Medical Research Conference (MRC 2010), Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 suppl 1, p. 21, abstract no. 26en_HK
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/127167-
dc.description.abstractINTRODUCTION: Previous studies on structural changes of Alzheimer’s disease (AD) have been focused on grey matter atrophy. There is a resurgence of interests on white matter integrity in this prominently increasing patient population. Diffusion tensor imaging (DTI) provides key information on the microstructural changes beyond macroscopic anatomical imaging by in-vivo tracing molecular diffusion in the brain, and the measured fractional anisotrophy (FA) value may represent axonal integrity of neuronal networks. Data of DTI from AD patients are limited, and the literature is controversial regarding whether the AD process has a greater impact on anterior versus posterior cerebral white matter. METHODS: Eighteen patients with mild AD and 16 age-matched healthy adults were recruited into the study. Demographic features of the two groups were comparable. Data of DTI were collected using a Philips 3.0T MRI scanner. Scan parameters were as follows: B0=800 s/mm2, FOV=224*224*140 mm, resolution=1.75*1.75*2 mm, non-collinear 15 directions was acquired. 3D T1 anatomy was also collected. We processed DTI data with DTI toolbox, and anatomical T1 data with VBM5 toolbox in SPM. Voxel-by-voxel analysis was applied to compare the difference in FA value, and volume of white matter of the normalised brain between the elderly and AD groups. RESULTS: Voxel-based analysis showed no significant difference in white matter volume between the two groups, but FA value was reduced greatly in the left anterior cingulate (−10,37,−3), right anterior cingulate (12,0,28), and left medial frontal lobe (−18,32,−12). Minor reduction was found in other brain regions such as body of the corpus callosum, right midbrain (12,−12,−6), right posterior corpus callosum (8,−44,2), and bilateral, especially right temporal lobe (36,−8,−20), upon right hippocampus. Coordinates (x,y,z) were labelled according to Talairach atlas. CONCLUSION: DTI could be valid and more sensitive than traditional T1 anatomy in detecting microscopic white matter lesions. Our data showed a greater decrement in FA value over the anterior than posterior brain regions, and this decrement was not due to white matter atrophy. Our findings are in line with the retrogenesis hypothesis which predicts reversed demyelination during the process of AD, as the frontal lobe fibres are myelinated relatively late during brain development. These results also support previous findings of our behavioural study that frontal lobe abnormality might be the neural basis for cognitive deficit in AD patients.-
dc.languageengen_HK
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.titleDeclined frontal white matter integrity in Alzheimer’s disease: a diffusion tensor imaging studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_HK
dc.identifier.emailLee, TMC: tmclee@hku.hken_HK
dc.identifier.emailChu, LW: lwchu@hkucc.hku.hken_HK
dc.identifier.emailMak, H: makkf@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authorityMak, H=rp00533en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros174980en_HK
dc.identifier.volume16en_HK
dc.identifier.issuesuppl 1en_HK
dc.identifier.spage21, abstract no. 26en_HK
dc.identifier.epage21, abstract no. 26-
dc.publisher.placeHong Kong-
dc.description.otherThe 15th Medical Research Conference; Department of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 suppl 1, p. 21, abstract no. 26-

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