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Conference Paper: A three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: relationships with relapse and neurocognitive function

TitleA three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: relationships with relapse and neurocognitive function
首發精神分裂症患者自發性眨眼率的三年前膽性研究:病情復發和神經認知功能之關係
Authors
KeywordsBlinking
Cognition
Dopamine
Recurrence
Schizophrenia
Issue Date2010
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.easap.asia and http://www.hkjpsych.com
Citation
The 2nd Biennial Schizophrenia International Research Conference, Florence, Italy, 10-14 April 2010. In East Asian Archives of Psychiatry, 2010, v. 20 n. 4, p. 174-179 How to Cite?
AbstractObjective: To examine the spontaneous blink rate over a 3-year period and its clinical and cognitive correlates among patients with first-episode schizophrenia. Methods: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative symptoms, and a range of cognitive features including verbal fluency, verbal memory, visual memory, and the Wisconsin Card Sorting Test performance. Results: When compared with a matched control group, there was a significantly higher blink rate at their 3-year follow-up but not at initial presentation. The increase in blink rate over time correlated positively with the number of relapses. It also correlated with logical memory, verbal fluency, categories completed, and perseverative errors in the Wisconsin Card Sorting Test. The increased blink rate also correlated with pre-morbid schizoid and schizotypal traits. All these correlations were statistically significant. Conclusion: The change in the blink rate over time may reflect underlying involvement of the dopaminergic system in mediating relapse and cognitive functions. © 2010 Hong Kong College of Psychiatrists.
Persistent Identifierhttp://hdl.handle.net/10722/126805
ISSN
2015 SCImago Journal Rankings: 0.331

 

DC FieldValueLanguage
dc.contributor.authorChan, KKSen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2010-10-31T12:49:31Z-
dc.date.available2010-10-31T12:49:31Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 2nd Biennial Schizophrenia International Research Conference, Florence, Italy, 10-14 April 2010. In East Asian Archives of Psychiatry, 2010, v. 20 n. 4, p. 174-179en_HK
dc.identifier.issn2078-9947-
dc.identifier.urihttp://hdl.handle.net/10722/126805-
dc.description.abstractObjective: To examine the spontaneous blink rate over a 3-year period and its clinical and cognitive correlates among patients with first-episode schizophrenia. Methods: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative symptoms, and a range of cognitive features including verbal fluency, verbal memory, visual memory, and the Wisconsin Card Sorting Test performance. Results: When compared with a matched control group, there was a significantly higher blink rate at their 3-year follow-up but not at initial presentation. The increase in blink rate over time correlated positively with the number of relapses. It also correlated with logical memory, verbal fluency, categories completed, and perseverative errors in the Wisconsin Card Sorting Test. The increased blink rate also correlated with pre-morbid schizoid and schizotypal traits. All these correlations were statistically significant. Conclusion: The change in the blink rate over time may reflect underlying involvement of the dopaminergic system in mediating relapse and cognitive functions. © 2010 Hong Kong College of Psychiatrists.-
dc.languageengen_HK
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.easap.asia and http://www.hkjpsych.com-
dc.relation.ispartofEast Asian Archives of Psychiatry-
dc.rightsEast Asian Archives of Psychiatry. Copyright © Hong Kong Academy of Medicine Press.-
dc.subjectBlinking-
dc.subjectCognition-
dc.subjectDopamine-
dc.subjectRecurrence-
dc.subjectSchizophrenia-
dc.titleA three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: relationships with relapse and neurocognitive functionen_HK
dc.title首發精神分裂症患者自發性眨眼率的三年前膽性研究:病情復發和神經認知功能之關係zh_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=2078-9947&volume=20&issue=4&spage=174&epage=179&date=2010&atitle=A+three-year+prospective+study+of+spontaneous+eye-blink+rate+in+first-episode+schizophrenia:+relationships+with+relapse+and+neurocognitive+function-
dc.identifier.emailChan, KKS: kevinchanks@hotmail.comen_HK
dc.identifier.emailHui, CLM: clmhui@hkusua.hku.hken_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailTang, JYM: jennitym@yahoo.com.hken_HK
dc.identifier.emailWong, GHY: ggloriawong@gmail.comen_HK
dc.identifier.emailChan, SKW: kwsherry@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros171613en_HK
dc.identifier.volume20-
dc.identifier.issue4-
dc.identifier.spage174-
dc.identifier.epage179-

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