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Article: Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathology

TitleGynaecological cancers in genetically susceptible women: new thoughts on tubal pathology
Authors
KeywordsBRCA
fallopian tube
HNPCC
ovarian
Peutz-Jeghers
Issue Date2009
PublisherThe Medicine Publishing Company. The Journal's web site is located at http://www.diagnostichistopathology.co.uk/
Citation
Diagnostic Histopathology, 2009, v. 15 n. 12, p. 545-553 How to Cite?
AbstractWomen may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are also reported. In recent years, serous tubal intraepithelial carcinoma and transitional metaplasia, its mimick, are identified at the fimbria of prophylactic salpingo-oophorectomy specimens. Immunohistochemical studies for p53 and MIB1 may help in the diagnosis. Tubal pathology is also occasionally reported in Peutz-Jeghers syndrome. Such findings emphasize on the importance of careful pathological examination of the fallopian tube in genetically susceptible women. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/126708
ISSN
2015 SCImago Journal Rankings: 0.167
References

 

DC FieldValueLanguage
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorShen, DHen_HK
dc.contributor.authorWingCheuk Wong, Ren_HK
dc.contributor.authorNgaYin Cheung, Aen_HK
dc.date.accessioned2010-10-31T12:43:55Z-
dc.date.available2010-10-31T12:43:55Z-
dc.date.issued2009en_HK
dc.identifier.citationDiagnostic Histopathology, 2009, v. 15 n. 12, p. 545-553en_HK
dc.identifier.issn1756-2317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126708-
dc.description.abstractWomen may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are also reported. In recent years, serous tubal intraepithelial carcinoma and transitional metaplasia, its mimick, are identified at the fimbria of prophylactic salpingo-oophorectomy specimens. Immunohistochemical studies for p53 and MIB1 may help in the diagnosis. Tubal pathology is also occasionally reported in Peutz-Jeghers syndrome. Such findings emphasize on the importance of careful pathological examination of the fallopian tube in genetically susceptible women. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherThe Medicine Publishing Company. The Journal's web site is located at http://www.diagnostichistopathology.co.uk/en_HK
dc.relation.ispartofDiagnostic Histopathologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectBRCAen_HK
dc.subjectfallopian tubeen_HK
dc.subjectHNPCCen_HK
dc.subjectovarianen_HK
dc.subjectPeutz-Jeghersen_HK
dc.titleGynaecological cancers in genetically susceptible women: new thoughts on tubal pathologyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1756-2317&volume=15&issue=12&spage=545&epage=553&date=2009&atitle=Gynaecological+cancers+in+genetically+susceptible+women:+new+thoughts+on+tubal+pathology-
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.emailNgaYin Cheung, A:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityNgaYin Cheung, A=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mpdhp.2009.09.001en_HK
dc.identifier.scopuseid_2-s2.0-70449521342en_HK
dc.identifier.hkuros176349en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70449521342&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue12en_HK
dc.identifier.spage545en_HK
dc.identifier.epage553en_HK
dc.publisher.placeUnited Kingdomen_HK

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