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Article: Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.
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TitleFunctional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.
 
AuthorsKhoo, US1
Chan, KY1
Ching, JC1
Chan, VS1
Ip, YC1
Yam, L1
Chu, CM1
Lai, ST1
So, KM1
Wong, TY1
Chung, PH1
Tam, P4
Yip, SP2
Sham, P2
Leung, GM3
Lin, CL
Peiris, JS5
 
Issue Date2009
 
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
 
CitationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 6, p. 26-29 [How to Cite?]
 
AbstractKey Messages 1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission. 2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.
 
ISSN1024-2708
2012 SCImago Journal Rankings: 0.255
 
DC FieldValue
dc.contributor.authorKhoo, US
 
dc.contributor.authorChan, KY
 
dc.contributor.authorChing, JC
 
dc.contributor.authorChan, VS
 
dc.contributor.authorIp, YC
 
dc.contributor.authorYam, L
 
dc.contributor.authorChu, CM
 
dc.contributor.authorLai, ST
 
dc.contributor.authorSo, KM
 
dc.contributor.authorWong, TY
 
dc.contributor.authorChung, PH
 
dc.contributor.authorTam, P
 
dc.contributor.authorYip, SP
 
dc.contributor.authorSham, P
 
dc.contributor.authorLeung, GM
 
dc.contributor.authorLin, CL
 
dc.contributor.authorPeiris, JS
 
dc.date.accessioned2010-10-31T12:42:58Z
 
dc.date.available2010-10-31T12:42:58Z
 
dc.date.issued2009
 
dc.description.abstractKey Messages 1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission. 2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 6, p. 26-29 [How to Cite?]
 
dc.identifier.epage29
 
dc.identifier.hkuros174759
 
dc.identifier.issn1024-2708
2012 SCImago Journal Rankings: 0.255
 
dc.identifier.issue5, supp. 6
 
dc.identifier.openurl
 
dc.identifier.pmid19801714
 
dc.identifier.scopuseid_2-s2.0-74949115016
 
dc.identifier.spage26
 
dc.identifier.urihttp://hdl.handle.net/10722/126691
 
dc.identifier.volume15 Suppl 6
 
dc.languageeng
 
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
 
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAntigens, CD - genetics
 
dc.subject.meshCell Adhesion Molecules - genetics - physiology
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshSevere Acute Respiratory Syndrome - blood - genetics
 
dc.titleFunctional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.
 
dc.typeArticle
 
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<contributor.author>Chan, KY</contributor.author>
<contributor.author>Ching, JC</contributor.author>
<contributor.author>Chan, VS</contributor.author>
<contributor.author>Ip, YC</contributor.author>
<contributor.author>Yam, L</contributor.author>
<contributor.author>Chu, CM</contributor.author>
<contributor.author>Lai, ST</contributor.author>
<contributor.author>So, KM</contributor.author>
<contributor.author>Wong, TY</contributor.author>
<contributor.author>Chung, PH</contributor.author>
<contributor.author>Tam, P</contributor.author>
<contributor.author>Yip, SP</contributor.author>
<contributor.author>Sham, P</contributor.author>
<contributor.author>Leung, GM</contributor.author>
<contributor.author>Lin, CL</contributor.author>
<contributor.author>Peiris, JS</contributor.author>
<date.accessioned>2010-10-31T12:42:58Z</date.accessioned>
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<identifier.uri>http://hdl.handle.net/10722/126691</identifier.uri>
<description.abstract>Key Messages 1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission. 2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.</description.abstract>
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<subject.mesh>Antigens, CD - genetics</subject.mesh>
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<subject.mesh>Polymorphism, Single Nucleotide</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Hospital Authority
  4. United Christian Hospital Hong Kong
  5. Hong Kong Polytechnic University