Article: Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.

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TitleFunctional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.
AuthorsKhoo, US1
Chan, KY1
Ching, JC1
Chan, VS1
Ip, YC1
Yam, L1
Chu, CM1
Lai, ST1
So, KM1
Wong, TY1
Chung, PH1
Tam, P1
Yip, SP1
Sham, P1
Leung, GM1
Lin, CL1
Peiris, JS1
Issue Date2009
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
CitationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 6, p. 26-29 [How to Cite?]
AbstractKey Messages 1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission. 2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.
ISSN1024-2708
2011 SCImago Journal Rankings: 0.054
DC Field
Value
dc.contributor.authorKhoo, US
dc.contributor.authorChan, KY
dc.contributor.authorChing, JC
dc.contributor.authorChan, VS
dc.contributor.authorIp, YC
dc.contributor.authorYam, L
dc.contributor.authorChu, CM
dc.contributor.authorLai, ST
dc.contributor.authorSo, KM
dc.contributor.authorWong, TY
dc.contributor.authorChung, PH
dc.contributor.authorTam, P
dc.contributor.authorYip, SP
dc.contributor.authorSham, P
dc.contributor.authorLeung, GM
dc.contributor.authorLin, CL
dc.contributor.authorPeiris, JS
dc.date.accessioned2010-10-31T12:42:58Z
dc.date.available2010-10-31T12:42:58Z
dc.date.issued2009
dc.description.abstractKey Messages 1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission. 2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.
dc.description.naturepublished_or_final_version
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 6, p. 26-29 [How to Cite?]
dc.identifier.epage29
dc.identifier.hkuros174759
dc.identifier.issn1024-2708
2011 SCImago Journal Rankings: 0.054
dc.identifier.issue5, supp. 6
dc.identifier.openurl
dc.identifier.pmid19801714
dc.identifier.scopuseid_2-s2.0-74949115016
dc.identifier.spage26
dc.identifier.urihttp://hdl.handle.net/10722/126691
dc.identifier.volume15 Suppl 6
dc.languageeng
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
dc.publisher.placeHong Kong
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAntigens, CD - genetics
dc.subject.meshCell Adhesion Molecules - genetics - physiology
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshSevere Acute Respiratory Syndrome - blood - genetics
dc.titleFunctional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine