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Article: Sputum cytology examination followed by autofluorescence bronchoscopy: A practical way of identifying early stage lung cancer in central airway

TitleSputum cytology examination followed by autofluorescence bronchoscopy: A practical way of identifying early stage lung cancer in central airway
Authors
KeywordsAutofluorescence bronchoscopy
Early detection
Lung cancer
Sputum cytology
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
Lung Cancer, 2009, v. 64 n. 3, p. 289-294 How to Cite?
AbstractBackground: The prognosis of early stage lung cancer was superior to that of late stages. We hypothesize that by using sputum cytology as the first screening method followed by autofluorescence bronchoscopy could detect early stage lung cancer in the central airway. Methods: During 18-month recruitment period, subjects at high risk for lung cancer (ever smoker accumulated more than 20 pack-year and above 40 years) followed up at Chest Clinics were invited to submit sputum for cytological examination. Subjects with sputum atypia were invited to have bronchoscopy, and CT thorax. After a mean follow-up of 39 ± 14 months, the characteristics of lung cancers detected in the group with sputum atypia and the group with normal sputum at baseline were assessed. Results: 181 subjects submitted sputum and primary lung cancer were diagnosed in 13. 46.2% of the lung cancers were in early stages. Bronchoscopy were performed in 85, and seven were confirmed to have lung cancer (six were in early stages). 81 had CT done and 92.6% had radiological abnormalities, though three lung cancers (all stage 0) were missed by CT. Five more primary lung cancers were diagnosed during the follow-up period: one in sputum atypia group and the other four (three were advanced adenocarcinoma) in normal sputum group. The overall sensitivity of sputum cytology in detecting lung cancer was 71.4% for all histology and 100% for squamous cell lung cancer. Conclusions: Sputum cytology examination followed by bronchoscopy was a practical way of detecting early stage lung cancer in central airway. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/126489
ISSN
2014 Impact Factor: 3.958
2014 SCImago Journal Rankings: 1.481
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, Ben_HK
dc.contributor.authorLam, SYen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorLam, DCLen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorTam, Cmen_HK
dc.contributor.authorPang, CBYen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLam, Wken_HK
dc.date.accessioned2010-10-31T12:31:38Z-
dc.date.available2010-10-31T12:31:38Z-
dc.date.issued2009en_HK
dc.identifier.citationLung Cancer, 2009, v. 64 n. 3, p. 289-294en_HK
dc.identifier.issn0169-5002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126489-
dc.description.abstractBackground: The prognosis of early stage lung cancer was superior to that of late stages. We hypothesize that by using sputum cytology as the first screening method followed by autofluorescence bronchoscopy could detect early stage lung cancer in the central airway. Methods: During 18-month recruitment period, subjects at high risk for lung cancer (ever smoker accumulated more than 20 pack-year and above 40 years) followed up at Chest Clinics were invited to submit sputum for cytological examination. Subjects with sputum atypia were invited to have bronchoscopy, and CT thorax. After a mean follow-up of 39 ± 14 months, the characteristics of lung cancers detected in the group with sputum atypia and the group with normal sputum at baseline were assessed. Results: 181 subjects submitted sputum and primary lung cancer were diagnosed in 13. 46.2% of the lung cancers were in early stages. Bronchoscopy were performed in 85, and seven were confirmed to have lung cancer (six were in early stages). 81 had CT done and 92.6% had radiological abnormalities, though three lung cancers (all stage 0) were missed by CT. Five more primary lung cancers were diagnosed during the follow-up period: one in sputum atypia group and the other four (three were advanced adenocarcinoma) in normal sputum group. The overall sensitivity of sputum cytology in detecting lung cancer was 71.4% for all histology and 100% for squamous cell lung cancer. Conclusions: Sputum cytology examination followed by bronchoscopy was a practical way of detecting early stage lung cancer in central airway. © 2008 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcanen_HK
dc.relation.ispartofLung Canceren_HK
dc.subjectAutofluorescence bronchoscopyen_HK
dc.subjectEarly detectionen_HK
dc.subjectLung canceren_HK
dc.subjectSputum cytologyen_HK
dc.subject.meshAdenocarcinoma - diagnosis - pathology-
dc.subject.meshCarcinoma, Squamous Cell - diagnosis - pathology-
dc.subject.meshCytological Techniques-
dc.subject.meshLung Neoplasms - diagnosis - pathology-
dc.subject.meshSputum - cytology-
dc.titleSputum cytology examination followed by autofluorescence bronchoscopy: A practical way of identifying early stage lung cancer in central airwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0169-5002&volume=64&issue=3&spage=289&epage=294&date=2009&atitle=Sputum+cytology+examination+followed+by+autofluorescence+bronchoscopy:+a+practical+way+of+identifying+early+stage+lung+cancer+in+central+airwayen_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailLam, DCL: dcllam@hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lungcan.2008.09.016en_HK
dc.identifier.pmid19010567-
dc.identifier.scopuseid_2-s2.0-67349208939en_HK
dc.identifier.hkuros174568en_HK
dc.identifier.hkuros155787-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349208939&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue3en_HK
dc.identifier.spage289en_HK
dc.identifier.epage294en_HK
dc.identifier.isiWOS:000266675900007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridLam, SY=7402279555en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridOoi, CGC=7007084909en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridLai, AYK=25641477800en_HK
dc.identifier.scopusauthoridTam, Cm=7201442997en_HK
dc.identifier.scopusauthoridPang, CBY=25641666400en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, Wk=7203021937en_HK
dc.identifier.citeulike4939764-

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