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Article: Sputum cytology examination followed by autofluorescence bronchoscopy: A practical way of identifying early stage lung cancer in central airway
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TitleSputum cytology examination followed by autofluorescence bronchoscopy: A practical way of identifying early stage lung cancer in central airway
 
AuthorsLam, B1
Lam, SY
Wong, MP1
Ooi, CGC1
Fong, DYT1
Lam, DCL1
Lai, AYK1
Tam, Cm
Pang, CBY1
Ip, MSM1
Lam, Wk1
 
KeywordsAutofluorescence bronchoscopy
Early detection
Lung cancer
Sputum cytology
 
Issue Date2009
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
 
CitationLung Cancer, 2009, v. 64 n. 3, p. 289-294 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lungcan.2008.09.016
 
AbstractBackground: The prognosis of early stage lung cancer was superior to that of late stages. We hypothesize that by using sputum cytology as the first screening method followed by autofluorescence bronchoscopy could detect early stage lung cancer in the central airway. Methods: During 18-month recruitment period, subjects at high risk for lung cancer (ever smoker accumulated more than 20 pack-year and above 40 years) followed up at Chest Clinics were invited to submit sputum for cytological examination. Subjects with sputum atypia were invited to have bronchoscopy, and CT thorax. After a mean follow-up of 39 ± 14 months, the characteristics of lung cancers detected in the group with sputum atypia and the group with normal sputum at baseline were assessed. Results: 181 subjects submitted sputum and primary lung cancer were diagnosed in 13. 46.2% of the lung cancers were in early stages. Bronchoscopy were performed in 85, and seven were confirmed to have lung cancer (six were in early stages). 81 had CT done and 92.6% had radiological abnormalities, though three lung cancers (all stage 0) were missed by CT. Five more primary lung cancers were diagnosed during the follow-up period: one in sputum atypia group and the other four (three were advanced adenocarcinoma) in normal sputum group. The overall sensitivity of sputum cytology in detecting lung cancer was 71.4% for all histology and 100% for squamous cell lung cancer. Conclusions: Sputum cytology examination followed by bronchoscopy was a practical way of detecting early stage lung cancer in central airway. © 2008 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0169-5002
2013 Impact Factor: 3.737
2013 SCImago Journal Rankings: 1.778
 
DOIhttp://dx.doi.org/10.1016/j.lungcan.2008.09.016
 
ISI Accession Number IDWOS:000266675900007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLam, B
 
dc.contributor.authorLam, SY
 
dc.contributor.authorWong, MP
 
dc.contributor.authorOoi, CGC
 
dc.contributor.authorFong, DYT
 
dc.contributor.authorLam, DCL
 
dc.contributor.authorLai, AYK
 
dc.contributor.authorTam, Cm
 
dc.contributor.authorPang, CBY
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorLam, Wk
 
dc.date.accessioned2010-10-31T12:31:38Z
 
dc.date.available2010-10-31T12:31:38Z
 
dc.date.issued2009
 
dc.description.abstractBackground: The prognosis of early stage lung cancer was superior to that of late stages. We hypothesize that by using sputum cytology as the first screening method followed by autofluorescence bronchoscopy could detect early stage lung cancer in the central airway. Methods: During 18-month recruitment period, subjects at high risk for lung cancer (ever smoker accumulated more than 20 pack-year and above 40 years) followed up at Chest Clinics were invited to submit sputum for cytological examination. Subjects with sputum atypia were invited to have bronchoscopy, and CT thorax. After a mean follow-up of 39 ± 14 months, the characteristics of lung cancers detected in the group with sputum atypia and the group with normal sputum at baseline were assessed. Results: 181 subjects submitted sputum and primary lung cancer were diagnosed in 13. 46.2% of the lung cancers were in early stages. Bronchoscopy were performed in 85, and seven were confirmed to have lung cancer (six were in early stages). 81 had CT done and 92.6% had radiological abnormalities, though three lung cancers (all stage 0) were missed by CT. Five more primary lung cancers were diagnosed during the follow-up period: one in sputum atypia group and the other four (three were advanced adenocarcinoma) in normal sputum group. The overall sensitivity of sputum cytology in detecting lung cancer was 71.4% for all histology and 100% for squamous cell lung cancer. Conclusions: Sputum cytology examination followed by bronchoscopy was a practical way of detecting early stage lung cancer in central airway. © 2008 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLung Cancer, 2009, v. 64 n. 3, p. 289-294 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lungcan.2008.09.016
 
dc.identifier.citeulike4939764
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.lungcan.2008.09.016
 
dc.identifier.epage294
 
dc.identifier.hkuros174568
 
dc.identifier.hkuros155787
 
dc.identifier.isiWOS:000266675900007
 
dc.identifier.issn0169-5002
2013 Impact Factor: 3.737
2013 SCImago Journal Rankings: 1.778
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid19010567
 
dc.identifier.scopuseid_2-s2.0-67349208939
 
dc.identifier.spage289
 
dc.identifier.urihttp://hdl.handle.net/10722/126489
 
dc.identifier.volume64
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
 
dc.publisher.placeIreland
 
dc.relation.ispartofLung Cancer
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdenocarcinoma - diagnosis - pathology
 
dc.subject.meshCarcinoma, Squamous Cell - diagnosis - pathology
 
dc.subject.meshCytological Techniques
 
dc.subject.meshLung Neoplasms - diagnosis - pathology
 
dc.subject.meshSputum - cytology
 
dc.subjectAutofluorescence bronchoscopy
 
dc.subjectEarly detection
 
dc.subjectLung cancer
 
dc.subjectSputum cytology
 
dc.titleSputum cytology examination followed by autofluorescence bronchoscopy: A practical way of identifying early stage lung cancer in central airway
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong