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Article: Habitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease

TitleHabitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease
Authors
KeywordsCoronary artery disease
Endothelial progenitor cells
Exercise
Physical activity level
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.escardio.org/initiatives/journals/prevention
Citation
European Journal Of Cardiovascular Prevention And Rehabilitation, 2009, v. 16 n. 4, p. 464-471 How to Cite?
AbstractBACKGROUND: Exercise training reduces mortality in patients with coronary artery disease (CAD); however, the impact of habitual physical activity level (PAL) on vascular endothelial function and circulating endothelial progenitor cells (EPCs) remain unknown. METHODS: We assessed habitual PAL using a validated International Physical Activity Questionnaire in 116 patients (67.8±9.5 years; 81% male) with stable CAD and preserved left ventricular ejection fraction ?45%. The number of circulating CD34/KDR+ and CD133/KDR+ EPCs was determined by flow cytometry, and brachial artery flow-mediated dilation (FMD) was measured. RESULTS: The mean PAL of CAD patients with 1644-MET-min/week (where MET is metabolic equivalents). With higher habitual PAL tertiles, there were significant linear trends of increased FMD (P=0.001) and CD133/KDR+ EPCs (P=0.03), but not of CD34/KDR+ EPCs. Patients with the highest tertile of PAL were associated with an absolute increase of 1.89% in FMD (relative increase 68%, P=0.003) and 0.12% in CD133/KDR+ EPCs (relative increase 44%, P=0.01) compared with those in the lowest tertile of PAL, after adjusting for age, sex, presence of hypertension, diabetes mellitus, hypercholesterolemia, smoking, and the use of medications including statins. However, neither CD34/KDR+ nor CD133/KDR+ EPCs significantly correlated with FMD. CONCLUSION: This study showed that higher habitual PAL in patients with CAD was associated with higher FMD and EPC count. Nonetheless, FMD only significantly correlated with increased PAL, but not EPC, suggesting that increased physical activity improves endothelial function through mechanisms other than increasing EPC count. © 2009 The European Society of Cardiology.
Persistent Identifierhttp://hdl.handle.net/10722/126484
ISSN
2013 Impact Factor: 3.691
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200507176137
Sun Chleh Yeh Heart Foundation
Funding Information:

The authors thank Dr Duncan Macfarlane, Institute of Human Performance, University of Hong Kong, for the use of the Chinese version of IPAQ in this study. This study was supported by the CRCG Small Project Funding of University of Hong Kong (Project No. 200507176137), and Sun Chleh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorLuk, THen_HK
dc.contributor.authorDai, YLen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorLee, SWLen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-10-31T12:31:21Z-
dc.date.available2010-10-31T12:31:21Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Journal Of Cardiovascular Prevention And Rehabilitation, 2009, v. 16 n. 4, p. 464-471en_HK
dc.identifier.issn1741-8267en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126484-
dc.description.abstractBACKGROUND: Exercise training reduces mortality in patients with coronary artery disease (CAD); however, the impact of habitual physical activity level (PAL) on vascular endothelial function and circulating endothelial progenitor cells (EPCs) remain unknown. METHODS: We assessed habitual PAL using a validated International Physical Activity Questionnaire in 116 patients (67.8±9.5 years; 81% male) with stable CAD and preserved left ventricular ejection fraction ?45%. The number of circulating CD34/KDR+ and CD133/KDR+ EPCs was determined by flow cytometry, and brachial artery flow-mediated dilation (FMD) was measured. RESULTS: The mean PAL of CAD patients with 1644-MET-min/week (where MET is metabolic equivalents). With higher habitual PAL tertiles, there were significant linear trends of increased FMD (P=0.001) and CD133/KDR+ EPCs (P=0.03), but not of CD34/KDR+ EPCs. Patients with the highest tertile of PAL were associated with an absolute increase of 1.89% in FMD (relative increase 68%, P=0.003) and 0.12% in CD133/KDR+ EPCs (relative increase 44%, P=0.01) compared with those in the lowest tertile of PAL, after adjusting for age, sex, presence of hypertension, diabetes mellitus, hypercholesterolemia, smoking, and the use of medications including statins. However, neither CD34/KDR+ nor CD133/KDR+ EPCs significantly correlated with FMD. CONCLUSION: This study showed that higher habitual PAL in patients with CAD was associated with higher FMD and EPC count. Nonetheless, FMD only significantly correlated with increased PAL, but not EPC, suggesting that increased physical activity improves endothelial function through mechanisms other than increasing EPC count. © 2009 The European Society of Cardiology.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.escardio.org/initiatives/journals/preventionen_HK
dc.relation.ispartofEuropean Journal of Cardiovascular Prevention and Rehabilitationen_HK
dc.subjectCoronary artery diseaseen_HK
dc.subjectEndothelial progenitor cellsen_HK
dc.subjectExerciseen_HK
dc.subjectPhysical activity levelen_HK
dc.subject.meshCoronary Artery Disease - physiopathology - rehabilitation-
dc.subject.meshEndothelial Cells - physiology-
dc.subject.meshEndothelium, Vascular - physiology-
dc.subject.meshExercise - physiology-
dc.subject.meshStem Cells - physiology-
dc.titleHabitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1741-8267&volume=16&issue=4&spage=464&epage=471&date=2009&atitle=Habitual+physical+activity+is+associated+with+endothelial+function+and+endothelial+progenitor+cells+in+patients+with+stable+coronary+artery+diseaseen_HK
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH: khkyiu@hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/HJR.0b013e32832b38been_HK
dc.identifier.pmid19587603-
dc.identifier.scopuseid_2-s2.0-70349201154en_HK
dc.identifier.hkuros174584en_HK
dc.identifier.hkuros158860-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349201154&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage464en_HK
dc.identifier.epage471en_HK
dc.identifier.isiWOS:000268869400009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuk, TH=35170682200en_HK
dc.identifier.scopusauthoridDai, YL=35168927300en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridLee, SWL=27169452400en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike8154766-

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