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Conference Paper: Genome-wide linkage scan for familial IgA nephropathy among southeast Asian Chinese: evidence for a suggestive novel susceptibility locus on chromosome 8p23

TitleGenome-wide linkage scan for familial IgA nephropathy among southeast Asian Chinese: evidence for a suggestive novel susceptibility locus on chromosome 8p23
Authors
Issue Date2009
PublisherAmerican Society of Nephrology.
Citation
Renal Week 2009 - The 2009 Annual Meeting of the American Society of Nephrology (ASN), San Diego, CA., 27 October-1 November 2009. In Renal Week 2009 Digital Abstract Book, 2009, p. 434A How to Cite?
AbstractIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with a high incidence and prevalence among Asians. Three genome-wide studies of familial IgAN among Caucasians have identified two major susceptibility loci on chromosomes 6q22 and 2q36, and two additional loci with suggestive linkage to IgAN on chromosomes 4q26-31 and 17q12-22. We report the preliminary results of a genome-wide scan of a large 4-generation Singaporean Chinese family (F66) for which we ascertained DNA samples for 66 members, including 9 affected members. Linkage analysis at 10 cM resolution was performed using the ABI PRISM Linkage Mapping Set Ver 2.5. By parametric analysis (assuming an autosomal dominant inheritance, a disease allele frequency of 0.001, phenocopy rate of 0.01, and penetrance of 75%), a region of suggestive linkage (maximum multipoint logarithm of odds [LOD] score of 2.23) was identified on chromosomes 8p23. By non-parametric analysis, a significant linkage to chromosome 8p23 (maximum multipoint LOD score 3.89, p-value 0.004) was found. Two additional microsatellite markers were genotyped in F66 along with 6 additional Chinese IgAN families from Hong Kong. Parametric analysis of all 7 families generated a maximum heterogeneous LOD score of 2.77 (α=1.0) over a region of 9.9 cM. The α score of 1.0 indicates genetic homogeneity at the 8p23 locus, suggestive of an “Asian-specific” susceptibility locus for IgAN. We are currently genotyping additional markers in F66 and a total of 23 Hong Kong families in order to conduct an “affected only” analysis to provide definitive evidence for linkage of familial IgAN among Southeast Asian Chinese to a novel susceptibility locus on chromosome 8p23.
DescriptionFriday Poster Session - Development/Cystic and Other Inherited Kidney Diseases/Genetics of Common Kidney Diseases/Systems Biology: Genetic Epidemiology/Gene Mapping-Common Kidney Diseases: No. F-PO1405
Persistent Identifierhttp://hdl.handle.net/10722/126407

 

DC FieldValueLanguage
dc.contributor.authorHsu, SIen_HK
dc.contributor.authorNiu, Yen_HK
dc.contributor.authorDavila, Sen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-10-31T12:26:54Z-
dc.date.available2010-10-31T12:26:54Z-
dc.date.issued2009en_HK
dc.identifier.citationRenal Week 2009 - The 2009 Annual Meeting of the American Society of Nephrology (ASN), San Diego, CA., 27 October-1 November 2009. In Renal Week 2009 Digital Abstract Book, 2009, p. 434Aen_HK
dc.identifier.urihttp://hdl.handle.net/10722/126407-
dc.descriptionFriday Poster Session - Development/Cystic and Other Inherited Kidney Diseases/Genetics of Common Kidney Diseases/Systems Biology: Genetic Epidemiology/Gene Mapping-Common Kidney Diseases: No. F-PO1405-
dc.description.abstractIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with a high incidence and prevalence among Asians. Three genome-wide studies of familial IgAN among Caucasians have identified two major susceptibility loci on chromosomes 6q22 and 2q36, and two additional loci with suggestive linkage to IgAN on chromosomes 4q26-31 and 17q12-22. We report the preliminary results of a genome-wide scan of a large 4-generation Singaporean Chinese family (F66) for which we ascertained DNA samples for 66 members, including 9 affected members. Linkage analysis at 10 cM resolution was performed using the ABI PRISM Linkage Mapping Set Ver 2.5. By parametric analysis (assuming an autosomal dominant inheritance, a disease allele frequency of 0.001, phenocopy rate of 0.01, and penetrance of 75%), a region of suggestive linkage (maximum multipoint logarithm of odds [LOD] score of 2.23) was identified on chromosomes 8p23. By non-parametric analysis, a significant linkage to chromosome 8p23 (maximum multipoint LOD score 3.89, p-value 0.004) was found. Two additional microsatellite markers were genotyped in F66 along with 6 additional Chinese IgAN families from Hong Kong. Parametric analysis of all 7 families generated a maximum heterogeneous LOD score of 2.77 (α=1.0) over a region of 9.9 cM. The α score of 1.0 indicates genetic homogeneity at the 8p23 locus, suggestive of an “Asian-specific” susceptibility locus for IgAN. We are currently genotyping additional markers in F66 and a total of 23 Hong Kong families in order to conduct an “affected only” analysis to provide definitive evidence for linkage of familial IgAN among Southeast Asian Chinese to a novel susceptibility locus on chromosome 8p23.-
dc.languageengen_HK
dc.publisherAmerican Society of Nephrology.-
dc.relation.ispartofRenal Week 2009 Digital Abstract Booken_HK
dc.titleGenome-wide linkage scan for familial IgA nephropathy among southeast Asian Chinese: evidence for a suggestive novel susceptibility locus on chromosome 8p23en_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLam, MF: feimflam@hku.hken_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.hkuros174084en_HK
dc.identifier.spage434A-
dc.identifier.epage434A-
dc.description.otherRenal Week 2009 - The 2009 Annual Meeting of the American Society of Nephrology (ASN), San Diego, CA., 27 October-1 November 2009. In Renal Week 2009 Digital Abstract Book, 2009, p. 434A-

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