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Conference Paper: Sleep apnea is an independent risk predictor for all-cause and cardiovascular mortality in peritoneal dialysis patients

TitleSleep apnea is an independent risk predictor for all-cause and cardiovascular mortality in peritoneal dialysis patients
Authors
Issue Date2009
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
The 4th Asian Chapter Meeting of the International Society for Peritoneal Dialysis (ISPD), Beijing, China, 15-17 October 2009. In Peritoneal Dialysis International, 2009, v. 29, suppl. 5, p. S7 How to Cite?
第四届国际腹膜透析学会亚洲地区会议, 中国, 北京, 2009年10月15-17日. How to Cite?
AbstractSleep apnea is increasingly being recognized as highly prevalent in dialysis patients. However, the prognostic implication of sleep apnea in this population is not known. We prospectively followed the clinical outcomes of continuous ambulatory peritoneal dialysis (PD) patients who were recruited into our “Sleep Apnea in PD Patients” program since the late 1990s. Baseline comprehensive overnight polysomnography was performed in 93 PD subjects [age (mean ± standard deviation): 56 ± 15 years; 52% men]. Significant sleep apnea, defined as an apnea–hypopnea index (AHI: frequency of apnea and hypopnea per hour of sleep) ≥ 15, was present in 51 subjects (55%). During a mean follow-up of 47.8 ± 27 months (range: 2.2 – 117.2 months), 30 deaths occurred (32%), of which 13 deaths (43%) were the result of cardiovascular causes. Cardiovascular mortality was 69% and 31% (p < 0.05) respectively for patients with and without sleep apnea (AHI ≥ 15) over the follow-up period. Using Kaplan–Meier analysis for the entire follow-up duration, patient survival was significantly higher in patients with a baseline AHI < 15 (71% vs. 36%, p = 0.017). Multivariate Cox regression analysis showed that the presence of significant sleep apnea was predictive of an increased all-cause mortality [hazard ratio (HR): 3.50; 95% confidence interval (CI): 1.32 to 6.76; p < 0.05] and cardiovascular death (HR: 6.1; 95% CI: 3.37 to 16.48).
Description第四届国际腹膜透析学会亚洲地区会议
Oral Presentations: Cardiovascular Complications
Persistent Identifierhttp://hdl.handle.net/10722/126405
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683

 

DC FieldValueLanguage
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorLeung, WSen_HK
dc.contributor.authorChu, CMen_HK
dc.contributor.authorHo, YWen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-10-31T12:26:48Z-
dc.date.available2010-10-31T12:26:48Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 4th Asian Chapter Meeting of the International Society for Peritoneal Dialysis (ISPD), Beijing, China, 15-17 October 2009. In Peritoneal Dialysis International, 2009, v. 29, suppl. 5, p. S7en_HK
dc.identifier.citation第四届国际腹膜透析学会亚洲地区会议, 中国, 北京, 2009年10月15-17日.zh_HK
dc.identifier.issn0896-8608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126405-
dc.description第四届国际腹膜透析学会亚洲地区会议-
dc.descriptionOral Presentations: Cardiovascular Complications-
dc.description.abstractSleep apnea is increasingly being recognized as highly prevalent in dialysis patients. However, the prognostic implication of sleep apnea in this population is not known. We prospectively followed the clinical outcomes of continuous ambulatory peritoneal dialysis (PD) patients who were recruited into our “Sleep Apnea in PD Patients” program since the late 1990s. Baseline comprehensive overnight polysomnography was performed in 93 PD subjects [age (mean ± standard deviation): 56 ± 15 years; 52% men]. Significant sleep apnea, defined as an apnea–hypopnea index (AHI: frequency of apnea and hypopnea per hour of sleep) ≥ 15, was present in 51 subjects (55%). During a mean follow-up of 47.8 ± 27 months (range: 2.2 – 117.2 months), 30 deaths occurred (32%), of which 13 deaths (43%) were the result of cardiovascular causes. Cardiovascular mortality was 69% and 31% (p < 0.05) respectively for patients with and without sleep apnea (AHI ≥ 15) over the follow-up period. Using Kaplan–Meier analysis for the entire follow-up duration, patient survival was significantly higher in patients with a baseline AHI < 15 (71% vs. 36%, p = 0.017). Multivariate Cox regression analysis showed that the presence of significant sleep apnea was predictive of an increased all-cause mortality [hazard ratio (HR): 3.50; 95% confidence interval (CI): 1.32 to 6.76; p < 0.05] and cardiovascular death (HR: 6.1; 95% CI: 3.37 to 16.48).-
dc.languageengen_HK
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com-
dc.relation.ispartofPeritoneal Dialysis Internationalen_HK
dc.relation.ispartofzh_HK
dc.titleSleep apnea is an independent risk predictor for all-cause and cardiovascular mortality in peritoneal dialysis patientsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLam, B: lambing@HKUCC.hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros174087en_HK
dc.identifier.volume29en_HK
dc.identifier.issuesuppl. 5-
dc.identifier.spageS7-
dc.identifier.epageS7-
dc.description.otherThe 4th Asian Chapter Meeting of the International Society for Peritoneal Dialysis (ISPD), Beijing, China, 15-17 October 2009.-

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