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Conference Paper: Association of two adiponectin gene variants with ischemic stroke in a Chinese cohort

TitleAssociation of two adiponectin gene variants with ischemic stroke in a Chinese cohort
Authors
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
The 32nd Annual Meeting of the Japan Neuroscience Society (Neuroscience 2009), Nagoya, Japan, 16-18 September 2009. In Neuroscience Research, 2009, v. 65 suppl. 1, p. S122 How to Cite?
AbstractStudies in many countries have shown an association between the plasma levels of adiponectin (AdipoQ) and the risk of cardiovascular disease, atherosclerosis and ischemic stroke (IS). However, the association between genetic variations in AdipoQ and IS has not been studied in Chinese. The aim of this study is to examine the association between single nucleotide polymorphisms (SNPs) of AdipoQ gene and ischemic stroke. A case-control study is being conducted in 310 Chinese with ischemic stroke and 310 sex- and age-matched controls with no documented ischemic heart disease and stroke. We examined on 5 SNPs of AdipoQ. All the SNPs in the cohort were detected by either TaqMan SNP genotyping assay or Sequenom. The GG genotype of rs266729 [OR: 2.31 (1.15-4.63), p-value: 0.018] and AA genotype of rs182052 [OR: 2.12 (1.26-3.57), p-value: 0.005] are significant higher risk of having ischemic stroke compare to dominant homozygous after adjusted with other risk factors. In conclusion, the recessive genotype of rs266729 and rs182052 associate with increased risk of IS in Chinese population.
DescriptionPresentation no. P1-l20
Persistent Identifierhttp://hdl.handle.net/10722/126388
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2010-10-31T12:25:47Z-
dc.date.available2010-10-31T12:25:47Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 32nd Annual Meeting of the Japan Neuroscience Society (Neuroscience 2009), Nagoya, Japan, 16-18 September 2009. In Neuroscience Research, 2009, v. 65 suppl. 1, p. S122en_HK
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/126388-
dc.descriptionPresentation no. P1-l20-
dc.description.abstractStudies in many countries have shown an association between the plasma levels of adiponectin (AdipoQ) and the risk of cardiovascular disease, atherosclerosis and ischemic stroke (IS). However, the association between genetic variations in AdipoQ and IS has not been studied in Chinese. The aim of this study is to examine the association between single nucleotide polymorphisms (SNPs) of AdipoQ gene and ischemic stroke. A case-control study is being conducted in 310 Chinese with ischemic stroke and 310 sex- and age-matched controls with no documented ischemic heart disease and stroke. We examined on 5 SNPs of AdipoQ. All the SNPs in the cohort were detected by either TaqMan SNP genotyping assay or Sequenom. The GG genotype of rs266729 [OR: 2.31 (1.15-4.63), p-value: 0.018] and AA genotype of rs182052 [OR: 2.12 (1.26-3.57), p-value: 0.005] are significant higher risk of having ischemic stroke compare to dominant homozygous after adjusted with other risk factors. In conclusion, the recessive genotype of rs266729 and rs182052 associate with increased risk of IS in Chinese population.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures-
dc.relation.ispartofNeuroscience Researchen_HK
dc.titleAssociation of two adiponectin gene variants with ischemic stroke in a Chinese cohorten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailOng, KL: okl2000@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailTso, AWK: awktso@hku.hken_HK
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.doi10.1016/j.neures.2009.09.582-
dc.identifier.hkuros174975en_HK
dc.identifier.volume65en_HK
dc.identifier.issuesuppl. 1-
dc.identifier.spageS122en_HK
dc.identifier.epageS122-
dc.identifier.isiWOS:000272421100801-
dc.publisher.placeIreland-
dc.description.otherThe 32nd Annual Meeting of the Japan Neuroscience Society (Neuroscience 2009), Nagoya, Japan, 16-18 September 2009. In Neuroscience Research, 2009, v. 65 suppl. 1, p. S122-

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