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Article: Meta-analysis of pulmonary valve replacement after operative repair of tetralogy of fallot
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TitleMeta-analysis of pulmonary valve replacement after operative repair of tetralogy of fallot
 
AuthorsCheung, EWY1
Wong, WHS1
Cheung, YF1
 
Issue Date2010
 
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
 
CitationAmerican Journal Of Cardiology, 2010, v. 106 n. 4, p. 552-557 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2010.03.065
 
AbstractThe present meta-analysis aimed to determine the outcomes and effect on right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot. The reported outcomes of surgical PVR in children and adults after tetralogy of Fallot repair were from relatively small observational studies. The PubMed database was searched from its inception to April 2009. Observational studies reporting on the following outcomes measures after surgical PVR were reviewed: early and late all-cause mortalities, the redo-PVR rate, and changes in the indexed RV volumes, ejection fraction, and QRS duration after PVR. Of the 305 citations screened, 15 met the criteria and were analyzed. The pooled early mortality rate (n = 595) was 2.1% (95% confidence interval [CI] 1.1% to 4.0%). The late mortality rate was 0.5%/patient-year (95% CI 0.2% to 0.8%/patient-year), and the redo-PVR rate was 1.9%/patient-year (95% CI 1.3% to 2.5%/patient-year). Data on RV volumes and ejection fractions were available from 5 studies (n = 141). The pooled mean difference in the indexed RV end-diastolic and end-systolic volume was -63 ml/m 2 (95% CI -55 to -72) and -37 ml/m 2 (95% CI -30 to -45), respectively. No significant changes in the pooled mean difference of the RV ejection fraction (95% CI -1% to 3%) or QRS duration (95% CI -10 to 1 ms) were observed. In conclusion, surgical PVR in patients after tetralogy of Fallot repair has been associated with low early and late mortality and significant decreases in RV volumes but no changes in the RV ejection fraction or QRS duration. © 2010 Elsevier Inc. All rights reserved.
 
ISSN0002-9149
2013 Impact Factor: 3.425
2013 SCImago Journal Rankings: 2.315
 
DOIhttp://dx.doi.org/10.1016/j.amjcard.2010.03.065
 
ISI Accession Number IDWOS:000281174500016
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, EWY
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2010-10-31T11:18:14Z
 
dc.date.available2010-10-31T11:18:14Z
 
dc.date.issued2010
 
dc.description.abstractThe present meta-analysis aimed to determine the outcomes and effect on right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot. The reported outcomes of surgical PVR in children and adults after tetralogy of Fallot repair were from relatively small observational studies. The PubMed database was searched from its inception to April 2009. Observational studies reporting on the following outcomes measures after surgical PVR were reviewed: early and late all-cause mortalities, the redo-PVR rate, and changes in the indexed RV volumes, ejection fraction, and QRS duration after PVR. Of the 305 citations screened, 15 met the criteria and were analyzed. The pooled early mortality rate (n = 595) was 2.1% (95% confidence interval [CI] 1.1% to 4.0%). The late mortality rate was 0.5%/patient-year (95% CI 0.2% to 0.8%/patient-year), and the redo-PVR rate was 1.9%/patient-year (95% CI 1.3% to 2.5%/patient-year). Data on RV volumes and ejection fractions were available from 5 studies (n = 141). The pooled mean difference in the indexed RV end-diastolic and end-systolic volume was -63 ml/m 2 (95% CI -55 to -72) and -37 ml/m 2 (95% CI -30 to -45), respectively. No significant changes in the pooled mean difference of the RV ejection fraction (95% CI -1% to 3%) or QRS duration (95% CI -10 to 1 ms) were observed. In conclusion, surgical PVR in patients after tetralogy of Fallot repair has been associated with low early and late mortality and significant decreases in RV volumes but no changes in the RV ejection fraction or QRS duration. © 2010 Elsevier Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Cardiology, 2010, v. 106 n. 4, p. 552-557 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2010.03.065
 
dc.identifier.citeulike7584576
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.amjcard.2010.03.065
 
dc.identifier.epage557
 
dc.identifier.hkuros176207
 
dc.identifier.isiWOS:000281174500016
 
dc.identifier.issn0002-9149
2013 Impact Factor: 3.425
2013 SCImago Journal Rankings: 2.315
 
dc.identifier.issue4
 
dc.identifier.pmid20691315
 
dc.identifier.scopuseid_2-s2.0-77955455573
 
dc.identifier.spage552
 
dc.identifier.urihttp://hdl.handle.net/10722/125219
 
dc.identifier.volume106
 
dc.languageeng
 
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.titleMeta-analysis of pulmonary valve replacement after operative repair of tetralogy of fallot
 
dc.typeArticle
 
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<description.abstract>The present meta-analysis aimed to determine the outcomes and effect on right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot. The reported outcomes of surgical PVR in children and adults after tetralogy of Fallot repair were from relatively small observational studies. The PubMed database was searched from its inception to April 2009. Observational studies reporting on the following outcomes measures after surgical PVR were reviewed: early and late all-cause mortalities, the redo-PVR rate, and changes in the indexed RV volumes, ejection fraction, and QRS duration after PVR. Of the 305 citations screened, 15 met the criteria and were analyzed. The pooled early mortality rate (n = 595) was 2.1% (95% confidence interval [CI] 1.1% to 4.0%). The late mortality rate was 0.5%/patient-year (95% CI 0.2% to 0.8%/patient-year), and the redo-PVR rate was 1.9%/patient-year (95% CI 1.3% to 2.5%/patient-year). Data on RV volumes and ejection fractions were available from 5 studies (n = 141). The pooled mean difference in the indexed RV end-diastolic and end-systolic volume was -63 ml/m 2 (95% CI -55 to -72) and -37 ml/m 2 (95% CI -30 to -45), respectively. No significant changes in the pooled mean difference of the RV ejection fraction (95% CI -1% to 3%) or QRS duration (95% CI -10 to 1 ms) were observed. In conclusion, surgical PVR in patients after tetralogy of Fallot repair has been associated with low early and late mortality and significant decreases in RV volumes but no changes in the RV ejection fraction or QRS duration. &#169; 2010 Elsevier Inc. All rights reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong