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Article: Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in chinese men: A 10-year prospective study

TitlePlasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in chinese men: A 10-year prospective study
Authors
KeywordsAntihypertensive agent
Oral antidiabetic agent
Pigment epithelium derived factor
Adult
Issue Date2010
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2010, v. 95 n. 11, p. 5074-5081 How to Cite?
AbstractObjective: Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A recent study found that PEDF played a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Here we investigated whether circulating PEDF levels predicted the development of the metabolic syndrome (MetS) in a 10-yr prospective study. Research Design and Methods: Baseline plasma PEDF levels were measured with an ELISA in 520 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. Multiple logistic regression was used to analyze whether PEDF was an independent factor related to the MetS at baseline. The role of PEDF in predicting the development of the MetS over 10 yr was analyzed using Cox regression analysis. Results: Plasma levels of PEDF were significantly higher in men than women. At baseline, sex-adjusted PEDF levels were significantly higher in subjects with MetS (P < 0.001), and the association remained significant (odds ratio: 1.17, P = 0.015), even after adjustment for covariates. Among the components of the MetS, PEDF was independently associated with hypertriglyceridemia (P = 0.026) and hypertension (P = 0.005). Of the 396 subjects without the MetS at baseline, a total of 80 had developed the MetS over 10 yr. High baseline sex-adjusted PEDF was an independent predictor of the development of the MetS in men (hazard ratio: 1.25, P = 0.034) but not in women. Conclusion: Plasma PEDF was significantly associated with the presence of the MetS and predicted the development of the MetS in Chinese men. Copyright © 2010 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/125046
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
Funding AgencyGrant Number
Health and Health Services Research Fund06070951
Research Grant CouncilHKU3/09C
Funding Information:

This work was supported by Health and Health Services Research Fund Grant 06070951 (to A. W. K. T.) and Research Grant Council Collaborative Research Fund Grant HKU3/09C (to K.S.L.L.).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChen, Cen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-10-31T11:08:25Z-
dc.date.available2010-10-31T11:08:25Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2010, v. 95 n. 11, p. 5074-5081en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/125046-
dc.description.abstractObjective: Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A recent study found that PEDF played a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Here we investigated whether circulating PEDF levels predicted the development of the metabolic syndrome (MetS) in a 10-yr prospective study. Research Design and Methods: Baseline plasma PEDF levels were measured with an ELISA in 520 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. Multiple logistic regression was used to analyze whether PEDF was an independent factor related to the MetS at baseline. The role of PEDF in predicting the development of the MetS over 10 yr was analyzed using Cox regression analysis. Results: Plasma levels of PEDF were significantly higher in men than women. At baseline, sex-adjusted PEDF levels were significantly higher in subjects with MetS (P < 0.001), and the association remained significant (odds ratio: 1.17, P = 0.015), even after adjustment for covariates. Among the components of the MetS, PEDF was independently associated with hypertriglyceridemia (P = 0.026) and hypertension (P = 0.005). Of the 396 subjects without the MetS at baseline, a total of 80 had developed the MetS over 10 yr. High baseline sex-adjusted PEDF was an independent predictor of the development of the MetS in men (hazard ratio: 1.25, P = 0.034) but not in women. Conclusion: Plasma PEDF was significantly associated with the presence of the MetS and predicted the development of the MetS in Chinese men. Copyright © 2010 by The Endocrine Society.en_HK
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.subjectAntihypertensive agent-
dc.subjectOral antidiabetic agent-
dc.subjectPigment epithelium derived factor-
dc.subjectAdult-
dc.titlePlasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in chinese men: A 10-year prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=95&issue=11&spage=5074&epage=5081&date=2010&atitle=Plasma+level+of+pigment+epithelium-derived+factor+is+independently+associated+with+the+development+of+the+metabolic+syndrome+in+chinese+men:+A+10-year+prospective+study-
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/jc.2010-0727en_HK
dc.identifier.pmid20685859-
dc.identifier.scopuseid_2-s2.0-78049490696en_HK
dc.identifier.hkuros180636en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78049490696&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue11en_HK
dc.identifier.spage5074en_HK
dc.identifier.epage5081en_HK
dc.identifier.isiWOS:000283844400055-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectA population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer-
dc.identifier.scopusauthoridChen, C=37025734000en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridLaw, LSC=36994511000en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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