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Conference Paper: Cross-talk between adipose tissue and vasculature: Role of adiponectin

TitleCross-talk between adipose tissue and vasculature: Role of adiponectin
Authors
KeywordsAdipokine
Endothelial function
Inflammation
Obesity
Vascular homeostasis
Issue Date2011
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1748-1708
Citation
The 18th Acta Physiologica International Symposium, Odense, Denmark, 24-26 July 2010. In Acta Physiologica, 2011, v. 203 n. 1, p. 167-180 How to Cite?
AbstractAdipose tissue is a highly dynamic endocrine organ, secreting a number of bioactive substances (adipokines) regulating insulin sensitivity, energy metabolism and vascular homeostasis. Dysfunctional adipose tissue is a key mediator that links obesity with insulin resistance, hypertension and cardiovascular disease. Obese adipose tissue is characterized by adipocyte hypertrophy and infiltration of inflammatory macrophages and lymphocytes, leading to the augmented production of pro-inflammatory adipokines and vasoconstrictors that induce endothelial dysfunction and vascular inflammation through their paracrine and endocrine actions. By contrast, the secretion of adiponectin, an adipokine with insulin sensitizing and anti-inflammatory activities, is decreased in obesity and its related pathologies. Emerging evidence suggests that adiponectin is protective against vascular dysfunction induced by obesity and diabetes, through its multiple favourable effects on glucose and lipid metabolism as well as on vascular function. Adiponectin improves insulin sensitivity and metabolic profiles, thus reducing the classical risk factors for cardiovascular disease. Furthermore, adiponectin protects the vasculature through its pleiotropic actions on endothelial cells, endothelial progenitor cells, smooth muscle cells and macrophages. Data from both animal and human investigations demonstrate that adiponectin is an important component of the adipo-vascular axis that mediates the cross-talk between adipose tissue and vasculature. This review highlights recent work on the vascular protective activities of adiponectin and discusses the molecular pathways underlying the vascular actions of this adipokine. © 2010 The Authors. Acta Physiologica © 2010 Scandinavian Physiological Society.
DescriptionConference Theme: Vascular Neuroeffector Mechanisms
Persistent Identifierhttp://hdl.handle.net/10722/125019
ISSN
2015 Impact Factor: 4.066
2015 SCImago Journal Rankings: 1.690
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKU 2/07C
HKU 779707M.
Funding Information:

This work was supported by collaborative research fund (HKU 2/07C) and General Research Fund (HKU 779707M.) from the Research Grants Council of Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, FYLen_HK
dc.contributor.authorCheng, KKYen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-10-31T11:06:57Z-
dc.date.available2010-10-31T11:06:57Z-
dc.date.issued2011en_HK
dc.identifier.citationThe 18th Acta Physiologica International Symposium, Odense, Denmark, 24-26 July 2010. In Acta Physiologica, 2011, v. 203 n. 1, p. 167-180en_HK
dc.identifier.issn1748-1708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125019-
dc.descriptionConference Theme: Vascular Neuroeffector Mechanisms-
dc.description.abstractAdipose tissue is a highly dynamic endocrine organ, secreting a number of bioactive substances (adipokines) regulating insulin sensitivity, energy metabolism and vascular homeostasis. Dysfunctional adipose tissue is a key mediator that links obesity with insulin resistance, hypertension and cardiovascular disease. Obese adipose tissue is characterized by adipocyte hypertrophy and infiltration of inflammatory macrophages and lymphocytes, leading to the augmented production of pro-inflammatory adipokines and vasoconstrictors that induce endothelial dysfunction and vascular inflammation through their paracrine and endocrine actions. By contrast, the secretion of adiponectin, an adipokine with insulin sensitizing and anti-inflammatory activities, is decreased in obesity and its related pathologies. Emerging evidence suggests that adiponectin is protective against vascular dysfunction induced by obesity and diabetes, through its multiple favourable effects on glucose and lipid metabolism as well as on vascular function. Adiponectin improves insulin sensitivity and metabolic profiles, thus reducing the classical risk factors for cardiovascular disease. Furthermore, adiponectin protects the vasculature through its pleiotropic actions on endothelial cells, endothelial progenitor cells, smooth muscle cells and macrophages. Data from both animal and human investigations demonstrate that adiponectin is an important component of the adipo-vascular axis that mediates the cross-talk between adipose tissue and vasculature. This review highlights recent work on the vascular protective activities of adiponectin and discusses the molecular pathways underlying the vascular actions of this adipokine. © 2010 The Authors. Acta Physiologica © 2010 Scandinavian Physiological Society.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1748-1708en_HK
dc.relation.ispartofActa Physiologicaen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectAdipokineen_HK
dc.subjectEndothelial functionen_HK
dc.subjectInflammationen_HK
dc.subjectObesityen_HK
dc.subjectVascular homeostasisen_HK
dc.titleCross-talk between adipose tissue and vasculature: Role of adiponectinen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1748-1708&volume=203&issue=1&spage=167&epage=180&date=2011&atitle=Cross-talk+between+adipose+tissue+and+vasculature:+role+of+adiponectinen_HK
dc.identifier.emailCheng, KKY: dorncky@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.authorityCheng, KKY=rp01672en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1748-1716.2010.02216.xen_HK
dc.identifier.pmid21062420-
dc.identifier.scopuseid_2-s2.0-80051659685en_HK
dc.identifier.hkuros175302en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051659685&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume203en_HK
dc.identifier.issue1en_HK
dc.identifier.spage167en_HK
dc.identifier.epage180en_HK
dc.identifier.isiWOS:000293921400015-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention-
dc.identifier.scopusauthoridLi, FYL=36079222200en_HK
dc.identifier.scopusauthoridCheng, KKY=7402997599en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.citeulike9714495-
dc.customcontrol.immutablesml 160630 amended-

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