File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes

TitleThe acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes
Authors
KeywordsACACB
Chinese
diabetic nephropathy
kidney
type 2 diabetes mellitus
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
Nephrology Dialysis Transplantation, 2010, v. 25 n. 12, p. 3931-3934 How to Cite?
AbstractBackground. A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.Methods. Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.Results. Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio=2.39; recessive model; P=0.0129).Conclusion. These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy. © 2010 The Author. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125008
ISSN
2015 Impact Factor: 4.085
2015 SCImago Journal Rankings: 1.780
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
NIHR01 DK053591
RO1 DK070941
Funding Information:

This study was supported by the Seed Funding Programme for Basic Research of the University of Hong Kong (S. C. W. T.) and NIH grants R01 DK053591 (D. W. B.) and RO1 DK070941 (B. I. F.). The authors are grateful to Wendy W. S. Tsui, Desmond Y.H. Yap, Maggie K. M. Ma, all Sai Ying Pun GOPC doctors and nurses for helping with patient recruitment, to Anita Tsang for specimen sorting, to Sandra Luen for coordination and to all the study participants.

References

 

DC FieldValueLanguage
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLeung, VTMen_HK
dc.contributor.authorChan, LYYen_HK
dc.contributor.authorWong, SSHen_HK
dc.contributor.authorChu, DWSen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorHo, YWen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorElbein, SCen_HK
dc.contributor.authorBowden, DWen_HK
dc.contributor.authorHicks, PJen_HK
dc.contributor.authorComeau, MEen_HK
dc.contributor.authorLangefeld, CDen_HK
dc.contributor.authorFreedman, BIen_HK
dc.date.accessioned2010-10-31T11:06:21Z-
dc.date.available2010-10-31T11:06:21Z-
dc.date.issued2010en_HK
dc.identifier.citationNephrology Dialysis Transplantation, 2010, v. 25 n. 12, p. 3931-3934en_HK
dc.identifier.issn0931-0509en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125008-
dc.description.abstractBackground. A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.Methods. Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.Results. Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio=2.39; recessive model; P=0.0129).Conclusion. These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy. © 2010 The Author. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/en_HK
dc.relation.ispartofNephrology Dialysis Transplantationen_HK
dc.subjectACACBen_HK
dc.subjectChineseen_HK
dc.subjectdiabetic nephropathyen_HK
dc.subjectkidneyen_HK
dc.subjecttype 2 diabetes mellitusen_HK
dc.subject.meshAcetyl-CoA Carboxylase - genetics-
dc.subject.meshDiabetes Mellitus, Type 2 - complications - ethnology - genetics-
dc.subject.meshDiabetic Nephropathies - ethnology - etiology - genetics-
dc.subject.meshGenetic Predisposition to Disease - genetics-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.titleThe acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0931-0509&volume=25&issue=12&spage=3931&epage=3934&date=2010&atitle=The+acetyl-coenzyme+A+carboxylase+beta++(ACACB)+gene+is+associated+with+nephropathy+in+Chinese+patients+with+type+2+diabetes-
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ndt/gfq303en_HK
dc.identifier.pmid20519229-
dc.identifier.pmcidPMC3108368-
dc.identifier.scopuseid_2-s2.0-78649500354en_HK
dc.identifier.hkuros197019en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649500354&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3931en_HK
dc.identifier.epage3934en_HK
dc.identifier.isiWOS:000284640400021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, SCW=7403437082en_HK
dc.identifier.scopusauthoridLeung, VTM=37112628300en_HK
dc.identifier.scopusauthoridChan, LYY=55182644100en_HK
dc.identifier.scopusauthoridWong, SSH=35785406900en_HK
dc.identifier.scopusauthoridChu, DWS=37111950500en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridHo, YW=7402555047en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridMa, L=7403574241en_HK
dc.identifier.scopusauthoridElbein, SC=7005744272en_HK
dc.identifier.scopusauthoridBowden, DW=7101785120en_HK
dc.identifier.scopusauthoridHicks, PJ=26030990200en_HK
dc.identifier.scopusauthoridComeau, ME=35298956200en_HK
dc.identifier.scopusauthoridLangefeld, CD=7004078855en_HK
dc.identifier.scopusauthoridFreedman, BI=7102825752en_HK
dc.identifier.citeulike8401872-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats