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Article: Natural history of chronic hepatitis C: Genotype 1 versus genotype 6

TitleNatural history of chronic hepatitis C: Genotype 1 versus genotype 6
Authors
KeywordsCirrhosis
Genotype 1
Genotype 6
Hepatitis C
Mortality
Natural history
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Journal Of Hepatology, 2010, v. 53 n. 3, p. 444-448 How to Cite?
AbstractBackground & Aims: Data on the natural history of chronic hepatitis C virus (HCV) genotype 6 is lacking. Methods: We compared the natural history of 138 HCV genotype 1 patients (median age: 50) with 78 HCV genotype 6 patients (median age: 46.5). Baseline demographic data including gender, route of transmission, liver biochemistry, HCV RNA levels, and serial alanine aminotransferase (ALT) levels were compared. The rate of development of complications and mortality were also analyzed. Results: A total of 71.7% and 8.7% of genotype 1 patients were infected through blood transfusion and intravenous drug addiction, respectively, compared with 56.4% and 28.2% for genotype 6 patients, respectively (p < 0.05). There were no differences in the baseline liver biochemistry in terms of ALT, albumin, bilirubin, alpha-fetoprotein (AFP), and HCV RNA levels between the two groups. Comparison of the proportion of normal and abnormal ALT levels between the two groups showed no statistical difference (p = 0.121). There was also no statistical difference in the cumulative rate of development of cirrhotic complications and hepatocellular carcinoma (p = 0.358) and mortality (p = 0.649) between the two groups. Conclusions: HCV genotype 1 patients were largely infected through blood transfusion, while a statistically larger proportion of genotype 6 patients were infected through intravenous drug injection. Both genotypes have comparable liver biochemistry, HCV viral load, and similar rates of development of cirrhotic complications and mortality. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124967
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorHung, Ien_HK
dc.contributor.authorYuen, Jen_HK
dc.contributor.authorYoung, Jen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-10-31T11:04:07Z-
dc.date.available2010-10-31T11:04:07Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Hepatology, 2010, v. 53 n. 3, p. 444-448en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124967-
dc.description.abstractBackground & Aims: Data on the natural history of chronic hepatitis C virus (HCV) genotype 6 is lacking. Methods: We compared the natural history of 138 HCV genotype 1 patients (median age: 50) with 78 HCV genotype 6 patients (median age: 46.5). Baseline demographic data including gender, route of transmission, liver biochemistry, HCV RNA levels, and serial alanine aminotransferase (ALT) levels were compared. The rate of development of complications and mortality were also analyzed. Results: A total of 71.7% and 8.7% of genotype 1 patients were infected through blood transfusion and intravenous drug addiction, respectively, compared with 56.4% and 28.2% for genotype 6 patients, respectively (p < 0.05). There were no differences in the baseline liver biochemistry in terms of ALT, albumin, bilirubin, alpha-fetoprotein (AFP), and HCV RNA levels between the two groups. Comparison of the proportion of normal and abnormal ALT levels between the two groups showed no statistical difference (p = 0.121). There was also no statistical difference in the cumulative rate of development of cirrhotic complications and hepatocellular carcinoma (p = 0.358) and mortality (p = 0.649) between the two groups. Conclusions: HCV genotype 1 patients were largely infected through blood transfusion, while a statistically larger proportion of genotype 6 patients were infected through intravenous drug injection. Both genotypes have comparable liver biochemistry, HCV viral load, and similar rates of development of cirrhotic complications and mortality. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.subjectCirrhosisen_HK
dc.subjectGenotype 1en_HK
dc.subjectGenotype 6en_HK
dc.subjectHepatitis Cen_HK
dc.subjectMortalityen_HK
dc.subjectNatural historyen_HK
dc.subject.meshCarcinoma, Hepatocellular - etiology-
dc.subject.meshHepacivirus - classification - genetics - pathogenicity-
dc.subject.meshHepatitis C, Chronic - complications - metabolism - virology-
dc.subject.meshHost-Pathogen Interactions-
dc.subject.meshLiver Cirrhosis - etiology-
dc.titleNatural history of chronic hepatitis C: Genotype 1 versus genotype 6en_HK
dc.typeArticleen_HK
dc.identifier.emailSeto, WK: wkseto2@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFung, J: jfung@sicklehut.comen_HK
dc.identifier.emailHung, I: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityHung, I=rp00508en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhep.2010.04.009en_HK
dc.identifier.pmid20554340-
dc.identifier.scopuseid_2-s2.0-77955852064en_HK
dc.identifier.hkuros179940en_HK
dc.identifier.hkuros181291-
dc.identifier.hkuros213669-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955852064&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage444en_HK
dc.identifier.epage448en_HK
dc.identifier.isiWOS:000281985900007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridHung, I=7006103457en_HK
dc.identifier.scopusauthoridYuen, J=7102620480en_HK
dc.identifier.scopusauthoridYoung, J=16949957200en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.citeulike7268904-

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