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Article: A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

TitleA single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese
Authors
Keywordsapolipoproteins
hypertriglyceridaemia
single nucleotide polymorphisms
triglycerides
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhg
Citation
European Journal Of Human Genetics, 2010, v. 18 n. 11, p. 1255-1260 How to Cite?
AbstractSingle nucleotide polymorphisms (SNPs) in the apolipoprotein A5 (APOA5) gene have been associated with hypertriglyceridaemia. We investigated which SNPs in the APOA5 gene were associated with triglyceride levels in two independent Chinese populations. In all, 1375 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study were genotyped for five tagging SNPs chosen from HapMap. Replication was sought in 1996 subjects from the Guangzhou Biobank Cohort Study. Among the five SNPs, rs662799 (-1131TC) was strongly related to log-transformed triglyceride levels among Hong Kong subjects (Β0.192, P2.6 × 10 13). Plasma triglyceride level was 36.1% higher in CC compared to TT genotype. This association was confirmed in Guangzhou subjects (Β0.159, P1.3 × 10 12), and was significantly irrespective of sex, age group, obesity, metabolic syndrome, hypertension, diabetes, smoking and alcohol drinking. The odds ratios and 95% confidence interval for plasma triglycerides 1.7 mmol/l associated with TC and CC genotypes were, respectively, 1.81 (1.37-2.39) and 2.22 (1.44-3.43) in Hong Kong and 1.27 (1.05-1.54) and 1.97 (1.42-2.73) in Guangzhou. Haplotype analysis suggested the association was due to rs662799 only. The corroborative findings in two independent populations indicate that the APOA5-1131TC polymorphism is an important and clinically relevant determinant of plasma triglyceride levels in the Chinese population. © 2010 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/124913
ISSN
2015 Impact Factor: 4.58
2015 SCImago Journal Rankings: 2.077
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30518001/CO301070202
Hong Kong Research Grant Council720/05
7229/01M
7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by the National Natural Science Foundation of China (30518001/CO301070202), the Hong Kong Research Grant Council (no. 720/05, no. 7229/01M and no. 7626/07M) and the Sun Chieh Yeh Heart Foundation. BMY Cheung had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

References

 

DC FieldValueLanguage
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorLi Jin, Yen_HK
dc.contributor.authorYue, XJen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, KSen_HK
dc.contributor.authorTomlinson, Ben_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2010-10-31T11:01:10Z-
dc.date.available2010-10-31T11:01:10Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Journal Of Human Genetics, 2010, v. 18 n. 11, p. 1255-1260en_HK
dc.identifier.issn1018-4813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124913-
dc.description.abstractSingle nucleotide polymorphisms (SNPs) in the apolipoprotein A5 (APOA5) gene have been associated with hypertriglyceridaemia. We investigated which SNPs in the APOA5 gene were associated with triglyceride levels in two independent Chinese populations. In all, 1375 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study were genotyped for five tagging SNPs chosen from HapMap. Replication was sought in 1996 subjects from the Guangzhou Biobank Cohort Study. Among the five SNPs, rs662799 (-1131TC) was strongly related to log-transformed triglyceride levels among Hong Kong subjects (Β0.192, P2.6 × 10 13). Plasma triglyceride level was 36.1% higher in CC compared to TT genotype. This association was confirmed in Guangzhou subjects (Β0.159, P1.3 × 10 12), and was significantly irrespective of sex, age group, obesity, metabolic syndrome, hypertension, diabetes, smoking and alcohol drinking. The odds ratios and 95% confidence interval for plasma triglycerides 1.7 mmol/l associated with TC and CC genotypes were, respectively, 1.81 (1.37-2.39) and 2.22 (1.44-3.43) in Hong Kong and 1.27 (1.05-1.54) and 1.97 (1.42-2.73) in Guangzhou. Haplotype analysis suggested the association was due to rs662799 only. The corroborative findings in two independent populations indicate that the APOA5-1131TC polymorphism is an important and clinically relevant determinant of plasma triglyceride levels in the Chinese population. © 2010 Macmillan Publishers Limited All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhgen_HK
dc.relation.ispartofEuropean Journal of Human Geneticsen_HK
dc.subjectapolipoproteinsen_HK
dc.subjecthypertriglyceridaemiaen_HK
dc.subjectsingle nucleotide polymorphismsen_HK
dc.subjecttriglyceridesen_HK
dc.subject.meshApolipoproteins A - genetics-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshCardiovascular Diseases - blood - ethnology - genetics-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshTriglycerides - blood-
dc.titleA single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1018-4813&volume=18&issue=11&spage=1255&epage=1260&date=2010&atitle=A+single+nucleotide+polymorphism+in+APOA5+determines+triglyceride+levels+in+Hong+Kong+and+Guangzhou+Chinese.-
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1038/ejhg.2010.93en_HK
dc.identifier.pmid20571505-
dc.identifier.pmcidPMC2987477-
dc.identifier.scopuseid_2-s2.0-77958468038en_HK
dc.identifier.hkuros180644en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958468038&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1255en_HK
dc.identifier.epage1260en_HK
dc.identifier.isiWOS:000283314700015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLiu, B=36079151900en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLin, JM=35409737900en_HK
dc.identifier.scopusauthoridLi Jin, Y=35932230900en_HK
dc.identifier.scopusauthoridYue, XJ=35410971600en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, KS=7404759405en_HK
dc.identifier.scopusauthoridTomlinson, B=16423466900en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.citeulike7378340-

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