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Article: Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

TitleAssociation of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
Authors
Issue Date2010
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
Citation
European Journal Of Endocrinology, 2010, v. 163 n. 2, p. 251-257 How to Cite?
AbstractObjective: Low plasma adiponectin level can predict the development of hypertension after 5 years in our population. We therefore investigated whether single-nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with hypertension. Design and methods: We genotyped 14 tagging SNPs in 1616 subjects with persistent normotensive or hypertensive status during a 6.4-year follow-up period in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2). Plasma adiponectin level was measured in 1385 subjects using in-house sandwich ELISA. Results: The minor G allele of the SNP rs266729 was significantly associated with higher odds of hypertension (odds ratio (95% confidence interval)=1.49 (1.13-1.95), P=0.0044) after adjusting for covariates. In stepwise multiple logistic regression, this SNP (P=0.006) was a significant independent factor of hypertension, together with age (P<0.001), body mass index (P<0.001), triglycerides (P=0.021), and insulin resistance index (P<0.001). Among the 14 SNPs, rs266729 (β=-0.067, P=0.0037), -10677C>T (β=0.069, P=0.0027), rs182052 (β=-0.097, P<0.0001), and rs12495941 (β=0.103, P<0.0001) were significantly associated with adiponectin level after adjusting for covariates. No significant sex interaction was found for the associations of SNPs with hypertension and adiponectin level. Similar results were obtained in haplotype analysis. Conclusion: In our population, genetic variants in the adiponectin gene influenced plasma adiponectin levels, and one of them was associated with hypertension. This study has provided further evidence for a role of adiponectin in the development of hypertension. © 2010 European Society of Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/124900
ISSN
2015 Impact Factor: 3.892
2015 SCImago Journal Rankings: 1.579
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M), and the Sun Chieh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-10-31T11:00:27Z-
dc.date.available2010-10-31T11:00:27Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Journal Of Endocrinology, 2010, v. 163 n. 2, p. 251-257en_HK
dc.identifier.issn0804-4643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124900-
dc.description.abstractObjective: Low plasma adiponectin level can predict the development of hypertension after 5 years in our population. We therefore investigated whether single-nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with hypertension. Design and methods: We genotyped 14 tagging SNPs in 1616 subjects with persistent normotensive or hypertensive status during a 6.4-year follow-up period in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2). Plasma adiponectin level was measured in 1385 subjects using in-house sandwich ELISA. Results: The minor G allele of the SNP rs266729 was significantly associated with higher odds of hypertension (odds ratio (95% confidence interval)=1.49 (1.13-1.95), P=0.0044) after adjusting for covariates. In stepwise multiple logistic regression, this SNP (P=0.006) was a significant independent factor of hypertension, together with age (P<0.001), body mass index (P<0.001), triglycerides (P=0.021), and insulin resistance index (P<0.001). Among the 14 SNPs, rs266729 (β=-0.067, P=0.0037), -10677C>T (β=0.069, P=0.0027), rs182052 (β=-0.097, P<0.0001), and rs12495941 (β=0.103, P<0.0001) were significantly associated with adiponectin level after adjusting for covariates. No significant sex interaction was found for the associations of SNPs with hypertension and adiponectin level. Similar results were obtained in haplotype analysis. Conclusion: In our population, genetic variants in the adiponectin gene influenced plasma adiponectin levels, and one of them was associated with hypertension. This study has provided further evidence for a role of adiponectin in the development of hypertension. © 2010 European Society of Endocrinology.en_HK
dc.languageengen_HK
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/en_HK
dc.relation.ispartofEuropean Journal of Endocrinologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdiponectin - blood - genetics-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshBlood Pressure - genetics-
dc.subject.meshBody Mass Index-
dc.subject.meshHypertension - blood - genetics-
dc.titleAssociation of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0804-4643&volume=163&issue=2&spage=251&epage=257&date=2010&atitle=Association+of+genetic+variants+in+the+adiponectin+gene+with+adiponectin+level+and+hypertension+in+Hong+Kong+Chinese.en_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1530/EJE-10-0251en_HK
dc.identifier.pmid20516205-
dc.identifier.scopuseid_2-s2.0-77955343146en_HK
dc.identifier.hkuros181105en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955343146&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue2en_HK
dc.identifier.spage251en_HK
dc.identifier.epage257en_HK
dc.identifier.isiWOS:000280484800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridLi, M=26661782700en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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