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Article: PPI-delayed diagnosis of gastrinoma: Oncologic victim of pharmacologic success

TitlePPI-delayed diagnosis of gastrinoma: Oncologic victim of pharmacologic success
Authors
KeywordsGastrin
Neuroendocrine carcinoma
Omeprazole
Pancreatic tumor
Zollinger-Ellison syndrome
Issue Date2010
PublisherSpringer Netherlands
Citation
Pathology And Oncology Research, 2010, v. 16 n. 1, p. 87-91 How to Cite?
AbstractFunctional neuroendocrine tumors are often low-grade malignant neoplasms that can be cured by surgery if detected early, and such detection may in turn be accelerated by the recognition of neuropeptide hypersecretion syndromes. Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs). Here we describe a clinical case in which time to diagnosis from the onset of peptic symptoms was delayed more than 10 years, in part reflecting symptom masking by continuous prescription of the PPI omeprazole. We propose diagnostic criteria for this under-recognized new clinical syndrome, and recommend that physicians routinely measure serum gastrin levels in persistent cases of PPI-dependent dyspepsia unassociated with H. pylori. © 2009 Arányi Lajos Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/124031
ISSN
2015 Impact Factor: 1.94
2015 SCImago Journal Rankings: 0.692
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, Hen_HK
dc.contributor.authorYau, Ten_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorChan, Gen_HK
dc.contributor.authorHui, Pen_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorHedley, AJen_HK
dc.contributor.authorEpstein, RJen_HK
dc.date.accessioned2010-10-19T04:34:27Z-
dc.date.available2010-10-19T04:34:27Z-
dc.date.issued2010en_HK
dc.identifier.citationPathology And Oncology Research, 2010, v. 16 n. 1, p. 87-91en_HK
dc.identifier.issn1219-4956en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124031-
dc.description.abstractFunctional neuroendocrine tumors are often low-grade malignant neoplasms that can be cured by surgery if detected early, and such detection may in turn be accelerated by the recognition of neuropeptide hypersecretion syndromes. Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs). Here we describe a clinical case in which time to diagnosis from the onset of peptic symptoms was delayed more than 10 years, in part reflecting symptom masking by continuous prescription of the PPI omeprazole. We propose diagnostic criteria for this under-recognized new clinical syndrome, and recommend that physicians routinely measure serum gastrin levels in persistent cases of PPI-dependent dyspepsia unassociated with H. pylori. © 2009 Arányi Lajos Foundation.en_HK
dc.languageengen_US
dc.publisherSpringer Netherlandsen_HK
dc.relation.ispartofPathology and Oncology Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsArányi Lajos Foundationen_HK
dc.subjectGastrinen_HK
dc.subjectNeuroendocrine carcinomaen_HK
dc.subjectOmeprazoleen_HK
dc.subjectPancreatic tumoren_HK
dc.subjectZollinger-Ellison syndromeen_HK
dc.titlePPI-delayed diagnosis of gastrinoma: Oncologic victim of pharmacologic successen_HK
dc.typeArticleen_HK
dc.identifier.emailYau, T: tyaucc@hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailHedley, AJ: hrmrajh@hkucc.hku.hken_HK
dc.identifier.emailEpstein, RJ: repstein@hku.hken_HK
dc.identifier.authorityYau, T=rp01466en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityHedley, AJ=rp00357en_HK
dc.identifier.authorityEpstein, RJ=rp00501en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s12253-009-9192-7en_HK
dc.identifier.pmid19693706-
dc.identifier.pmcidPMC2953631-
dc.identifier.scopuseid_2-s2.0-77949653296en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949653296&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue1en_HK
dc.identifier.spage87en_HK
dc.identifier.epage91en_HK
dc.identifier.isiWOS:000275458600013-
dc.publisher.placeNetherlandsen_HK
dc.description.otherSpringer Open Choice, 01 Dec 2010-
dc.identifier.scopusauthoridWong, H=23089414000en_HK
dc.identifier.scopusauthoridYau, T=23391533100en_HK
dc.identifier.scopusauthoridChan, P=7403497715en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridChan, G=7202355321en_HK
dc.identifier.scopusauthoridHui, P=36901726100en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridHedley, AJ=7102584095en_HK
dc.identifier.scopusauthoridEpstein, RJ=34975074500en_HK
dc.identifier.citeulike5625613-

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