Article: Hepatitis B and Renal Disease

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TitleHepatitis B and Renal Disease
AuthorsChan, TM1
KeywordsHepatitis B
Kidney transplantation
Issue Date2010
PublisherSpringer Healthcare. The Journal's web site is located at http://www.springerlink.com/content/1540-3416/
CitationCurrent Hepatitis Reports, 2010, v. 9 n. 2, p. 99-105 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11901-010-0042-6
AbstractGlomerulonephritis is an important extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The uncommon occurrence, variability in renal histopathology, and heterogeneity in clinical course present challenges in clinical studies and have resulted in a relative paucity of data and uncertainty with regard to the optimal management of HBV-related glomerular diseases. The advent of nucleos(t)ide analogue medications that effectively suppress HBV replication has markedly altered the clinical outcomes of kidney transplant recipients with HBV infection, but the emergence of drug resistance is an escalating problem. This article reviews the recent knowledge of the pathogenesis and treatment of HBV-related membranous nephropathy, and discusses the management of hepatitis B in kidney transplant recipients, which is continuously evolving. © 2010 The Author(s).
ISSN1540-3416
2011 SCImago Journal Rankings: 0.053
DOIhttp://dx.doi.org/10.1007/s11901-010-0042-6
PubMed Central IDPMC2861764
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, TM
dc.date.accessioned2010-10-19T04:34:07Z
dc.date.available2010-10-19T04:34:07Z
dc.date.issued2010
dc.description.abstractGlomerulonephritis is an important extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The uncommon occurrence, variability in renal histopathology, and heterogeneity in clinical course present challenges in clinical studies and have resulted in a relative paucity of data and uncertainty with regard to the optimal management of HBV-related glomerular diseases. The advent of nucleos(t)ide analogue medications that effectively suppress HBV replication has markedly altered the clinical outcomes of kidney transplant recipients with HBV infection, but the emergence of drug resistance is an escalating problem. This article reviews the recent knowledge of the pathogenesis and treatment of HBV-related membranous nephropathy, and discusses the management of hepatitis B in kidney transplant recipients, which is continuously evolving. © 2010 The Author(s).
dc.description.naturepublished_or_final_version
dc.description.otherSpringer Open Choice, 01 Dec 2010
dc.identifier.citationCurrent Hepatitis Reports, 2010, v. 9 n. 2, p. 99-105 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11901-010-0042-6
dc.identifier.citeulike7042908
dc.identifier.doihttp://dx.doi.org/10.1007/s11901-010-0042-6
dc.identifier.eissn1541-0706
dc.identifier.epage105
dc.identifier.hkuros178492
dc.identifier.issn1540-3416
2011 SCImago Journal Rankings: 0.053
dc.identifier.issue2
dc.identifier.pmcidPMC2861764
dc.identifier.pmid20461128
dc.identifier.scopuseid_2-s2.0-77955983326
dc.identifier.spage99
dc.identifier.urihttp://hdl.handle.net/10722/124025
dc.identifier.volume9
dc.languageeng
dc.publisherSpringer Healthcare. The Journal's web site is located at http://www.springerlink.com/content/1540-3416/
dc.publisher.placeUnited States
dc.relation.ispartofCurrent Hepatitis Reports
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.rightsThe original publication is available at www.springerlink.com
dc.subjectHepatitis B
dc.subjectKidney transplantation
dc.titleHepatitis B and Renal Disease
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong