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Conference Paper: Differential occurrence of microsatellite instability in mitochondrial genome of gynecological cancers

TitleDifferential occurrence of microsatellite instability in mitochondrial genome of gynecological cancers
Authors
Issue Date2004
PublisherAmerican Association for Cancer Research
Citation
AACR 95th Annual Meeting, Orlando FL, 27–31 March 2004. In Cancer Research, 2004, v. 64 n. 7S, p. 212 Abstract no. 927 How to Cite?
AbstractTo investigate the occurrence of mitochondrial microsatellite instability (mtMSI) in human primary ovarian, endometrial, cervical, and breast carcinomas, we screened 13 microsatellite regions in mtDNA of cancer tissues and their matched normal controls. Four out of 13 microsatellite markers that start at np303, np514, np965 and np16184, respectively, exhibited instability, indicated by change in length of short base-repetitive sequences of mtDNA relative to control. About 20.5% (16/78) ovarian cancer patients, 48.4% (30/62) endometrial cancer patients, 25.4% (18/71) cervical cancer patients and 27.5% (14/51) breast cancer patients carried one or more mtMSI. The frequency of mtMSI in endometrial cancer was significantly higher than in the other three types of cancer (P value=0.003; χ2=14.269; 3 df). In particular, mtMSI was frequently detected in the D-loop region. A relatively long C tract interrupted by a T residue is the mtMSI hotspot in all four types of cancer studied. The differential occurrence of the mtMSI in various cancer types suggests that the generation of mtMSI may vary from one cancer to another. It may be partly attribute to the different mtDNA repair efficient in various tissues. The relatively high prevalence of mtMSI may be a potential new tool for detection of human cancers.
Persistent Identifierhttp://hdl.handle.net/10722/113491
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-26T04:18:12Z-
dc.date.available2010-09-26T04:18:12Z-
dc.date.issued2004en_HK
dc.identifier.citationAACR 95th Annual Meeting, Orlando FL, 27–31 March 2004. In Cancer Research, 2004, v. 64 n. 7S, p. 212 Abstract no. 927-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/113491-
dc.description.abstractTo investigate the occurrence of mitochondrial microsatellite instability (mtMSI) in human primary ovarian, endometrial, cervical, and breast carcinomas, we screened 13 microsatellite regions in mtDNA of cancer tissues and their matched normal controls. Four out of 13 microsatellite markers that start at np303, np514, np965 and np16184, respectively, exhibited instability, indicated by change in length of short base-repetitive sequences of mtDNA relative to control. About 20.5% (16/78) ovarian cancer patients, 48.4% (30/62) endometrial cancer patients, 25.4% (18/71) cervical cancer patients and 27.5% (14/51) breast cancer patients carried one or more mtMSI. The frequency of mtMSI in endometrial cancer was significantly higher than in the other three types of cancer (P value=0.003; χ2=14.269; 3 df). In particular, mtMSI was frequently detected in the D-loop region. A relatively long C tract interrupted by a T residue is the mtMSI hotspot in all four types of cancer studied. The differential occurrence of the mtMSI in various cancer types suggests that the generation of mtMSI may vary from one cancer to another. It may be partly attribute to the different mtDNA repair efficient in various tissues. The relatively high prevalence of mtMSI may be a potential new tool for detection of human cancers.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleDifferential occurrence of microsatellite instability in mitochondrial genome of gynecological cancersen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.hkuros92893en_HK

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