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Conference Paper: Nasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification

TitleNasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classification
Authors
Issue Date2008
PublisherSociety of Nuclear Medicine and Molecular Imaging
Citation
The 2008 Annual Meeting of the Society of Nuclear Medicine (SNM), New Orleans, LA., 14-18 June 2008. In The Journal of Nuclear Medicine, 2008, v. 49 suppl. 1, p. 146P How to Cite?
AbstractObjectives: To evaluate the relationship between tumour SUVmax and size and TNM staging in patients with nasopharyngeal carcinoma (NPC). Methods: We retrospectively analyzed the PET/CT findings of 25 consecutive patients (age range 15-80 yrs, mean 51.1 ± 14.3) with histologically proven NPC at initial diagnosis (n=11) or recurrence (n=14) over a 8-month period. Histological type was undifferentiated carcinoma in all except one of squamous cell carcinoma. All pts were scanned prior to commencement of treatment or had completed treatment at least 1-year ago. SUVmax of the 18F-FDG-avid lesion in the nasopharynx and maximum diameters were measured on axial PET reconstruction and the co-registered contrast-enhanced CT scan respectively by two radiologists in consensus blinded to the clinical details. All patients were staged using the AJC/UICC TNM staging system. Multiple linear regression analysis was performed to study the simultaneous influence of tumour SUVmax and size on T-, N-, and M staging. Results: Mean SUVmax and tumour size was 5.6 ± 3.91 (range: 1.80 – 16.00) and 4.58 ± 5.92 cm2 (range: 0.18 – 27.5), respectively. Using univariate analysis, there were significant correlations between T-stage and tumour size (r=0.671, p<0.001), T-stage and SUVmax (r=0.436, p=0.030) and tumour size and SUVmax (r=0.758, p<0.001). Multiple linear regression analysis revealed tumour size to be the only independent variable that significantly affected T-stage (adjusted R2=0.351, p=0.003). Similar results were found when new and recurrent cases were separately analyzed. Conclusions: No significant correlation was found between SUVmax of the primary tumour and the TNM stages. Tumour size was the only independent predictor of T-stage.
Persistent Identifierhttp://hdl.handle.net/10722/105639
ISSN
2015 Impact Factor: 5.849
2015 SCImago Journal Rankings: 2.541

 

DC FieldValueLanguage
dc.contributor.authorChan, KSen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorNgan, SSCen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-25T22:42:31Z-
dc.date.available2010-09-25T22:42:31Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 2008 Annual Meeting of the Society of Nuclear Medicine (SNM), New Orleans, LA., 14-18 June 2008. In The Journal of Nuclear Medicine, 2008, v. 49 suppl. 1, p. 146P-
dc.identifier.issn0161-5505-
dc.identifier.urihttp://hdl.handle.net/10722/105639-
dc.description.abstractObjectives: To evaluate the relationship between tumour SUVmax and size and TNM staging in patients with nasopharyngeal carcinoma (NPC). Methods: We retrospectively analyzed the PET/CT findings of 25 consecutive patients (age range 15-80 yrs, mean 51.1 ± 14.3) with histologically proven NPC at initial diagnosis (n=11) or recurrence (n=14) over a 8-month period. Histological type was undifferentiated carcinoma in all except one of squamous cell carcinoma. All pts were scanned prior to commencement of treatment or had completed treatment at least 1-year ago. SUVmax of the 18F-FDG-avid lesion in the nasopharynx and maximum diameters were measured on axial PET reconstruction and the co-registered contrast-enhanced CT scan respectively by two radiologists in consensus blinded to the clinical details. All patients were staged using the AJC/UICC TNM staging system. Multiple linear regression analysis was performed to study the simultaneous influence of tumour SUVmax and size on T-, N-, and M staging. Results: Mean SUVmax and tumour size was 5.6 ± 3.91 (range: 1.80 – 16.00) and 4.58 ± 5.92 cm2 (range: 0.18 – 27.5), respectively. Using univariate analysis, there were significant correlations between T-stage and tumour size (r=0.671, p<0.001), T-stage and SUVmax (r=0.436, p=0.030) and tumour size and SUVmax (r=0.758, p<0.001). Multiple linear regression analysis revealed tumour size to be the only independent variable that significantly affected T-stage (adjusted R2=0.351, p=0.003). Similar results were found when new and recurrent cases were separately analyzed. Conclusions: No significant correlation was found between SUVmax of the primary tumour and the TNM stages. Tumour size was the only independent predictor of T-stage.-
dc.languageengen_HK
dc.publisherSociety of Nuclear Medicine and Molecular Imaging-
dc.relation.ispartofThe Journal of Nuclear Medicineen_HK
dc.titleNasopharyngeal carcinoma: relationship between 18F-FDG PET/CT maximum standardized uptake value and lesion size with TNM classificationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KS: kitsum80@gamil.comen_HK
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_HK
dc.identifier.emailNgan, SSC: scngan@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.hkuros146940en_HK
dc.identifier.volume49-
dc.identifier.issuesuppl. 1-
dc.identifier.spage146P-
dc.identifier.epage146P-

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