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Conference Paper: White matter fractional anisotropy (FA) in the assessment of treatment-induced neurotoxicity in childhood cancer survivors: association with neurocognitive function

TitleWhite matter fractional anisotropy (FA) in the assessment of treatment-induced neurotoxicity in childhood cancer survivors: association with neurocognitive function
Authors
Issue Date2005
PublisherInternational Society for Magnetic Resonance in Medicine
Citation
International Society for Magnetic Resonance in Medicine 13th Scientific Meeting & Exhibition, Miami, FL, 7-13 May 2005 How to Cite?
AbstractWe evaluated the mean white matter fractional anisotropy (FA) of childhood medulloblastoma and acute lymphoblastic leukemia survivors who had undergone standardized whole brain irradiation and chemotherapy treatment regimes, to determine if the severity of reduction in FA (compared to normal subjects) correlates with IQ scores; full-scale IQ (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ). We found statistically significant correlations between deviation in mean white matter FA and FSIQ (r = 0.661, p< 0.0001), VIQ (r = 0.500, p = 0.007), PIQ (r = 0.716, p < 0.0001), suggesting that white matter FA is a useful biomarker of treatment-induced neurotoxicity.
Persistent Identifierhttp://hdl.handle.net/10722/105593

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorFung, ASMen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorYip, LCKen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-25T22:40:37Z-
dc.date.available2010-09-25T22:40:37Z-
dc.date.issued2005en_HK
dc.identifier.citationInternational Society for Magnetic Resonance in Medicine 13th Scientific Meeting & Exhibition, Miami, FL, 7-13 May 2005-
dc.identifier.urihttp://hdl.handle.net/10722/105593-
dc.description.abstractWe evaluated the mean white matter fractional anisotropy (FA) of childhood medulloblastoma and acute lymphoblastic leukemia survivors who had undergone standardized whole brain irradiation and chemotherapy treatment regimes, to determine if the severity of reduction in FA (compared to normal subjects) correlates with IQ scores; full-scale IQ (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ). We found statistically significant correlations between deviation in mean white matter FA and FSIQ (r = 0.661, p< 0.0001), VIQ (r = 0.500, p = 0.007), PIQ (r = 0.716, p < 0.0001), suggesting that white matter FA is a useful biomarker of treatment-induced neurotoxicity.-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine-
dc.relation.ispartofInternational Society for Magnetic Resonance in Medicine Scientific Meeting & Exhibitionen_HK
dc.titleWhite matter fractional anisotropy (FA) in the assessment of treatment-induced neurotoxicity in childhood cancer survivors: association with neurocognitive functionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_HK
dc.identifier.emailQiu, D: dgiu@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.hkuros100354en_HK

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